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The effective analysis of high-dimensional Electronic Health Record (EHR) data, with substantial potential for healthcare research, presents notable methodological challenges. Employing predictive modeling guided by a knowledge graph (KG),…

Methodology · Statistics 2025-11-06 Zhiwei Xu , Ziming Gan , Doudou Zhou , Shuting Shen , Junwei Lu , Tianxi Cai

Electronic Health Records (EHRs) and routine documentation practices play a vital role in patients' daily care, providing a holistic record of health, diagnoses, and treatment. However, complex and verbose EHR narratives overload healthcare…

Computation and Language · Computer Science 2025-02-26 Yanjun Gao , Ruizhe Li , Emma Croxford , John Caskey , Brian W Patterson , Matthew Churpek , Timothy Miller , Dmitriy Dligach , Majid Afshar

Multimodal electronic health record (EHR) data is useful for disease risk prediction based on medical domain knowledge. However, general medical knowledge must be adapted to specific healthcare settings and patient populations to achieve…

Artificial Intelligence · Computer Science 2025-09-29 Mbithe Nzomo , Deshendran Moodley

Deep learning models have shown tremendous potential in learning representations, which are able to capture some key properties of the data. This makes them great candidates for transfer learning: Exploiting commonalities between different…

Electronic Health Records (EHR)-based disease prediction models have demonstrated significant clinical value in promoting precision medicine and enabling early intervention. However, existing large language models face two major challenges:…

Computation and Language · Computer Science 2025-06-19 Junke Wang , Hongshun Ling , Li Zhang , Longqian Zhang , Fang Wang , Yuan Gao , Zhi Li

Medical text learning has recently emerged as a promising area to improve healthcare due to the wide adoption of electronic health record (EHR) systems. The complexity of the medical text such as diverse length, mixed text types, and full…

Computation and Language · Computer Science 2022-10-11 Yong He , Cheng Wang , Shun Zhang , Nan Li , Zhaorong Li , Zhenyu Zeng

Knowledge graph (KG) embedding has been used to benefit the diagnosis of animal diseases by analyzing electronic medical records (EMRs), such as notes and veterinary records. However, learning representations to capture entities and…

Artificial Intelligence · Computer Science 2023-09-08 Van Thuy Hoang , Sang Thanh Nguyen , Sangmyeong Lee , Jooho Lee , Luong Vuong Nguyen , O-Joun Lee

Due to the increasing adoption of electronic health records (EHR), large scale EHRs have become another rich data source for translational clinical research. Despite its potential, deriving generalizable knowledge from EHR data remains…

Machine Learning · Statistics 2023-06-01 Junwei Lu , Jin Yin , Tianxi Cai

The integration of multimodal Electronic Health Records (EHR) data has significantly improved clinical predictive capabilities. Leveraging clinical notes and multivariate time-series EHR, existing models often lack the medical context…

Artificial Intelligence · Computer Science 2024-02-13 Yinghao Zhu , Changyu Ren , Shiyun Xie , Shukai Liu , Hangyuan Ji , Zixiang Wang , Tao Sun , Long He , Zhoujun Li , Xi Zhu , Chengwei Pan

Distributed representations of medical concepts have been used to support downstream clinical tasks recently. Electronic Health Records (EHR) capture different aspects of patients' hospital encounters and serve as a rich source for…

Computation and Language · Computer Science 2020-01-07 Shaika Chowdhury , Chenwei Zhang , Philip S. Yu , Yuan Luo

Electronic Health Record (EHR) data can be represented as discrete counts over a high dimensional set of possible procedures, diagnoses, and medications. Supervised topic models present an attractive option for incorporating EHR data as…

Machine Learning · Computer Science 2019-11-21 Jason Ren , Russell Kunes , Finale Doshi-Velez

Extensive adoption of electronic health records (EHRs) offers opportunities for their use in various downstream clinical analyses. To accomplish this purpose, enriching an EHR cohort with external knowledge (e.g., standardized medical…

Machine Learning · Computer Science 2024-06-13 Ahmad Wisnu Mulyadi , Heung-Il Suk

Electronic health records (EHR) are increasingly being used for constructing disease risk prediction models. Feature engineering in EHR data however is challenging due to their highly dimensional and heterogeneous nature. Low-dimensional…

Computation and Language · Computer Science 2018-11-29 Spiros Denaxas , Pontus Stenetorp , Sebastian Riedel , Maria Pikoula , Richard Dobson , Harry Hemingway

Medical knowledge graphs (KGs) constructed from Electronic Medical Records (EMR) contain abundant information about patients and medical entities. The utilization of KG embedding models on these data has proven to be efficient for different…

Information Retrieval · Computer Science 2021-04-06 Aynur Guluzade , Endri Kacupaj , Maria Maleshkova

Motivation: Electronic health record (EHR) data provides a new venue to elucidate disease comorbidities and latent phenotypes for precision medicine. To fully exploit its potential, a realistic data generative process of the EHR data needs…

Machine Learning · Computer Science 2021-05-05 Ziyang Song , Xavier Sumba Toral , Yixin Xu , Aihua Liu , Liming Guo , Guido Powell , Aman Verma , David Buckeridge , Ariane Marelli , Yue Li

Treatment effect estimation (TEE) is the task of determining the impact of various treatments on patient outcomes. Current TEE methods fall short due to reliance on limited labeled data and challenges posed by sparse and high-dimensional…

Machine Learning · Computer Science 2024-03-07 Ruoqi Liu , Lingfei Wu , Ping Zhang

The integration of multimodal Electronic Health Records (EHR) data has significantly advanced clinical predictive capabilities. Existing models, which utilize clinical notes and multivariate time-series EHR data, often fall short of…

Computation and Language · Computer Science 2025-02-27 Yinghao Zhu , Changyu Ren , Zixiang Wang , Xiaochen Zheng , Shiyun Xie , Junlan Feng , Xi Zhu , Zhoujun Li , Liantao Ma , Chengwei Pan

Knowledge Graph Embedding (KGE) techniques are crucial in learning compact representations of entities and relations within a knowledge graph, facilitating efficient reasoning and knowledge discovery. While existing methods typically focus…

Computation and Language · Computer Science 2024-10-29 Pengcheng Jiang , Lang Cao , Cao Xiao , Parminder Bhatia , Jimeng Sun , Jiawei Han

Electronic Health Records (EHR) are high-dimensional data with implicit connections among thousands of medical concepts. These connections, for instance, the co-occurrence of diseases and lab-disease correlations can be informative when…

Machine Learning · Computer Science 2021-03-29 Weicheng Zhu , Narges Razavian

The widespread application of Electronic Health Records (EHR) data in the medical field has led to early successes in disease risk prediction using deep learning methods. These methods typically require extensive data for training due to…

Machine Learning · Computer Science 2024-11-28 Shibo Li , Hengliang Cheng , Weihua Li
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