Related papers: Enhanced precision of circadian rhythm by output s…
We focus on various measures of the fluctuations of the sequence of intervals between beats of the human heart, and how such fluctuations can be used to assess the presence or likelihood of cardiovascular disease. We examine sixteen such…
Chemically active systems such as living cells are maintained out of thermal equilibrium due to chemical events which generate heat and lead to active fluctuations. A key question is to understand on which time and length scales active…
Gene regulatory dynamics is governed by molecular processes and therefore exhibits an inherent stochasticity. However, for the survival of an organism it is a strict necessity that this intrinsic noise does not prevent robust functioning of…
The use of office measurement of Blood Pressure (BP) as well as of the mean on day-time, on night-time or on 24h does not accurately describe the changes of the BP circadian rhythm. Moreover, several risk factors affect this rhythm but…
In this paper, we prove the nonlinear stability under localized perturbations of spectrally stable time-periodic source defects of reaction-diffusion systems. Consisting of a core that emits periodic wave trains to each side, source defects…
All clocks, classical or quantum, are open non equilibrium irreversible systems subject to the constraints of thermodynamics. Using examples I show that these constraints necessarily limit the performance of clocks and that good clocks…
How does soil pollution affect a plant's circadian clock? Are there any differences between how the clock reacts when exposed to different concentrations of elements of the periodic table? If so, can we characterise these differences? We…
Fluctuations in the abundance of molecules in the living cell may affect its growth and well being. For regulatory molecules (e.g., signaling proteins or transcription factors), fluctuations in their expression can affect the levels of…
Shared upstream dynamical processes are frequently the source of common inputs in various physical and biological systems. However, due to finite signal transmission speeds and differences in the distance to the source, time shifts between…
A stochastic process, when subject to resetting to its initial condition at a constant rate, generically reaches a non-equilibrium steady state. We study analytically how the steady state is approached in time and find an unusual relaxation…
Circadian disruption contributes to adverse effects on sleep, performance, and health. One accepted method to track continuous daily changes in circadian timing is to measure core body temperature (CBT), and establish daily,…
All clocks, in some form or another, use the evolution of nature towards higher entropy states to quantify the passage of time. Due to the statistical nature of the second law and corresponding entropy flows, fluctuations fundamentally…
Self-organized network dynamics prevails for systems across physics, biology and engineering. How external signals generate distributed responses in networked systems fundamentally underlies their function, yet is far from fully understood.…
The theta rhythm is important for many cognitive functions including spatial processing, memory encoding, and memory recall. The information processing underlying these functions is thought to rely on consistent, phase-specific spiking…
We have re-analyzed the stability of pulse arrival times from pulsars and white dwarfs using several analysis tools for measuring the noise characteristics of sampled time and frequency data. We show that the best terrestrial artificial…
Discrete time crystals are periodically driven systems that display spontaneous symmetry breaking of time translation invariance in the form of indefinite subharmonic oscillations. We introduce a thermodynamically consistent model for a…
Organisms are equipped with regulatory systems that display a variety of dynamical behaviours ranging from simple stable steady states, to switching and multistability, to oscillations. Earlier work has shown that oscillations in protein…
Oscillatory systems with time-delayed pulsatile feedback appear in various applied and theoretical research areas, and received a growing interest in the last years. For such systems, we report a remarkable scenario of destabilization of a…
Measurements of any property of a microscopic system are bound to show significant deviations from the average, due to thermal fluctuations. For time-integrated currents such as heat, work or entropy production in a steady state, it is in…
Clock synchronization is critical for maintaining low error rates in quantum key distribution. Here, we describe how a frequency mismatch between the transmitter and receiver clocks affects the quantum bit error rate in quantum key…