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Clinical data-driven research requires clinical expertise, programming skills, access to patient data, and extensive documentation, creating barriers and slowing the pace for clinicians and external researchers. To address this, we…

Computation and Language · Computer Science 2026-04-22 Taehun Kim , Hyeryun Park , Hyeonhoon Lee , Yushin Lee , Kyungsang Kim , Hyung-Chul Lee

Reconstructing full spatio-temporal dynamics from sparse observations in both space and time remains a central challenge in complex systems, as measurements can be spatially incomplete and can be also limited to narrow temporal windows. Yet…

Machine Learning · Computer Science 2026-04-02 Yuxuan Bao , Xingyue Zhang , J. Nathan Kutz

Modern database workloads are highly predictable: query streams are dominated by recurring jobs and templates, even when their arrival order is not known in advance. This motivates a learning-augmented view of online differentially private…

Cryptography and Security · Computer Science 2026-05-05 Pranay Mundra , Adam Sealfon , Ziteng Sun , Quanquan C. Liu

The ability to characterize proteins at sequence-level resolution is vital to biological research. Currently, the leading method for protein sequencing is by liquid chromatography mass spectrometry (LC-MS) whereas proteins are reduced to…

Genomics · Quantitative Biology 2025-07-11 René L. Warren

The sudden rise of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic early 2020 throughout the world has called into drastic action measures to do instant detection and reduce the spread rate. The common diagnostics…

Instrumentation and Detectors · Physics 2024-06-12 Aref Asghari , Chao Wang , Kyoung Min Yoo , Hamed Dalir , Ray T. Chen

With the rapid spread of COVID-19 worldwide, viral genomic data is available in the order of millions of sequences on public databases such as GISAID. This Big Data creates a unique opportunity for analysis towards the research of effective…

Machine Learning · Computer Science 2022-10-14 Sarwan Ali , Babatunde Bello , Zahra Tayebi , Murray Patterson

With the goal of improving the security of Internet protocols, we seek faster, semi-automatic methods to discover new vulnerabilities in protocols such as DNS, BGP, and others. To this end, we introduce the LLM-Assisted Protocol Attack…

Cryptography and Security · Computer Science 2025-10-23 R. Can Aygun , Yehuda Afek , Anat Bremler-Barr , Leonard Kleinrock

The long-term effects of Postacute Sequelae of SARS-CoV-2, known as PASC, pose a significant challenge to healthcare systems worldwide. Accurate identification of progression events, such as hospitalization and reinfection, is essential for…

Machine Learning · Computer Science 2025-07-01 Jing Wang , Amar Sra , Jeremy C. Weiss

The genetic evolution of SARS-CoV-2 has caused recurring epidemic waves, understanding its global dispersal patterns is critical for effective surveillance. We developed the Site-based mutation dynamics - Equal Power Sampling (S-EPS)…

The massive amount of genomic data appearing for SARS-CoV-2 since the beginning of the COVID-19 pandemic has challenged traditional methods for studying its dynamics. As a result, new methods such as Pangolin, which can scale to the…

Quantitative Methods · Quantitative Biology 2022-11-16 Prakash Chourasia , Sarwan Ali , Simone Ciccolella , Gianluca Della Vedova , Murray Patterson

Data represented as strings abounds in biology, linguistics, document mining, web search and many other fields. Such data often have a hierarchical structure, either because they were artificially designed and composed in a hierarchical…

Artificial Intelligence · Computer Science 2016-06-14 Payam Siyari , Bistra Dilkina , Constantine Dovrolis

Given the severity of the SARS-CoV-2 pandemic, a major challenge is to rapidly repurpose existing approved drugs for clinical interventions. While a number of data-driven and experimental approaches have been suggested in the context of…

The fast evolution of SARS-CoV-2 and other infectious viruses poses a grand challenge to the rapid response in terms of viral tracking, diagnostics, and design and manufacture of monoclonal antibodies (mAbs) and vaccines, which are both…

Biomolecules · Quantitative Biology 2024-11-20 JunJie Wee , Guo-Wei Wei

We devise a novel inference algorithm to effectively solve the cancer progression model reconstruction problem. Our empirical analysis of the accuracy and convergence rate of our algorithm, CAncer PRogression Inference (CAPRI), shows that…

Process-Aware Information System (PAIS) are IT systems that manages, supports business processes and generate large event logs from execution of business processes. An event log is represented as a tuple of the form CaseID, TimeStamp,…

Databases · Computer Science 2017-01-03 Jeevan Joishi , Ashish Sureka

The expanding adoption of digital pathology has enabled the curation of large repositories of histology whole slide images (WSIs), which contain a wealth of information. Similar pathology image search offers the opportunity to comb through…

Computer Vision and Pattern Recognition · Computer Science 2021-07-30 Chengkuan Chen , Ming Y. Lu , Drew F. K. Williamson , Tiffany Y. Chen , Andrew J. Schaumberg , Faisal Mahmood

SARS-CoV-2, like any other virus, continues to mutate as it spreads, according to an evolutionary process. Unlike any other virus, the number of currently available sequences of SARS-CoV-2 in public databases such as GISAID is already…

Populations and Evolution · Quantitative Biology 2021-10-13 Sarwan Ali , Tamkanat-E-Ali , Muhammad Asad Khan , Imdadullah Khan , Murray Patterson

We present Lyncs-API, a Python API for Lattice QCD applications currently under development. Lyncs aims to bring several widely used libraries for Lattice QCD under a common framework. Lyncs flexibly links to libraries for CPUs and GPUs in…

High Energy Physics - Lattice · Physics 2022-01-12 Simone Bacchio , Jacob Finkenrath , Christodoulos Stylianou

Due to SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) being a novel virus, there are currently no known effective antiviral drugs capable of slowing its progress. To accelerate the discovery of potential drug candidates,…

Biomolecules · Quantitative Biology 2020-09-29 Lokesh Agrawal , Thanasis Poullikkas , Scott Eisenhower , Carlo Monsanto , Ranjith Kumar Bakku

The coronavirus disease 2019 (COVID-19) global pandemic poses the threat of overwhelming healthcare systems with unprecedented demands for intensive care resources. Managing these demands cannot be effectively conducted without a nationwide…

Machine Learning · Computer Science 2020-07-29 Zhaozhi Qian , Ahmed M. Alaa , Mihaela van der Schaar