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Large language models (LLMs) are increasingly used as simulated participants in social science experiments, but their behavior is often unstable and highly sensitive to design choices. Prior evaluations frequently conflate base-model…

Artificial Intelligence · Computer Science 2026-02-03 Xuan Liu , Haoyang Shang , Zizhang Liu , Xinyan Liu , Yunze Xiao , Yiwen Tu , Haojian Jin

Random numbers are at the heart of every agent-based model (ABM) of health and disease. By representing each individual in a synthetic population, agent-based models enable detailed analysis of intervention impact and parameter sensitivity.…

Quantitative Methods · Quantitative Biology 2024-09-09 Daniel J. Klein , Romesh G. Abeysuriya , Robyn M. Stuart , Cliff C. Kerr

Simulations, although powerful in accurately replicating real-world systems, often remain inaccessible to non-technical users due to their complexity. Conversely, large language models (LLMs) provide intuitive, language-based interactions…

Computation and Language · Computer Science 2025-05-22 Jacob Kleiman , Kevin Frank , Joseph Voyles , Sindy Campagna

Agent-based modeling and simulation is a useful method to study biological phenomena in a wide range of fields, from molecular biology to ecology. Since there is currently no agreed-upon standard way to specify such models it is not always…

Quantitative Methods · Quantitative Biology 2010-10-14 Franziska Hinkelmann , David Murrugarra , Abdul Salam Jarrah , Reinhard Laubenbacher

This is the first part of the comprehensive review, focusing on the historical development of Agent-Based Modeling (ABM) and its classic cases. It begins by discussing the development history and design principles of Agent-Based Modeling…

Multiagent Systems · Computer Science 2025-10-22 Xiao Xue , Deyu Zhou , Ming Zhang , Fei-Yue Wang

We study the benefits of reinforcement learning (RL) environments based on agent-based models (ABM). While ABMs are known to offer microfoundational simulations at the cost of computational complexity, we empirically show in this work that…

Multiagent Systems · Computer Science 2022-05-02 Mohamed Akrout , Amal Feriani , Bob McLeod

The concept of the 'agent' has profoundly shaped Artificial Intelligence (AI) research, guiding development from foundational theories to contemporary applications like Large Language Model (LLM)-based systems. This paper critically…

Artificial Intelligence · Computer Science 2025-09-16 Jesse Gardner , Vladimir A. Baulin

Agent-based modelling is a powerful tool when simulating human systems, yet when human behaviour cannot be described by simple rules or maximising one's own profit, we quickly reach the limits of this methodology. Machine learning has the…

Multiagent Systems · Computer Science 2022-01-21 Georg Jäger , Daniel Reisinger

Automated machine learning (AutoML) accelerates AI development by automating tasks in the development pipeline, such as optimal model search and hyperparameter tuning. Existing AutoML systems often require technical expertise to set up…

Machine Learning · Computer Science 2025-06-09 Patara Trirat , Wonyong Jeong , Sung Ju Hwang

The emergence of large language model (LLM)-based agents has significantly advanced the development of autonomous machine learning (ML) engineering. However, the dominant prompt-based paradigm exhibits limitations: smaller models lack the…

Computation and Language · Computer Science 2026-05-04 Zexi Liu , Jingyi Chai , Xinyu Zhu , Shuo Tang , Rui Ye , Bo Zhang , Lei Bai , Siheng Chen

Recent advances in large language models (LLMs) have enabled the development of AI agents that exhibit increasingly human-like behaviors, including planning, adaptation, and social dynamics across diverse, interactive, and open-ended…

Neurons and Cognition · Quantitative Biology 2025-06-13 Lin Chen , Yunke Zhang , Jie Feng , Haoye Chai , Honglin Zhang , Bingbing Fan , Yibo Ma , Shiyuan Zhang , Nian Li , Tianhui Liu , Nicholas Sukiennik , Keyu Zhao , Yu Li , Ziyi Liu , Fengli Xu , Yong Li

We present a machine learning (ML)-assisted framework bridging manifold learning, neural networks, Gaussian processes, and Equation-Free multiscale modeling, for (a) detecting tipping points in the emergent behavior of complex systems, and…

The advancement in generative AI could be boosted with more accessible mathematics. Beyond human-AI chat, large language models (LLMs) are emerging in programming, algorithm discovery, and theorem proving, yet their genomics application is…

Other Quantitative Biology · Quantitative Biology 2023-07-07 Melanie Swan , Takashi Kido , Eric Roland , Renato P. dos Santos

Artificial Intelligence (AI) and Machine Learning (ML) are weaving their way into the fabric of society, where they are playing a crucial role in numerous facets of our lives. As we witness the increased deployment of AI and ML in various…

Emerging Technologies · Computer Science 2022-12-23 Sasitharan Balasubramaniam , Samitha Somathilaka , Sehee Sun , Adrian Ratwatte , Massimiliano Pierobon

With the rapid development of artificial intelligence, intelligent decision-making techniques have gradually surpassed human levels in various human-machine competitions, especially in complex multi-agent cooperative task scenarios.…

Multiagent Systems · Computer Science 2025-03-18 Weiqiang Jin , Hongyang Du , Biao Zhao , Xingwu Tian , Bohang Shi , Guang Yang

Mining biological data is an emergent area at the intersection between bioinformatics and data mining (DM). The intelligent agent based model is a popular approach in constructing Distributed Data Mining (DDM) systems to address scalable…

Computational Engineering, Finance, and Science · Computer Science 2015-09-11 G. S. Bhamra , A. K. Verma , R. B. Patel

Agent-based models (ABMs) offer a powerful framework for understanding complex systems. However, their computational demands often become a significant barrier as the number of agents and complexity of the simulation increase. Traditional…

Multiagent Systems · Computer Science 2025-10-23 Steffen Fürst , Tim Conrad , Carlo Jaeger , Sarah Wolf

Reinforcement learning has driven impressive advances in machine learning. Simultaneously, quantum-enhanced machine learning algorithms using quantum annealing underlie heavy developments. Recently, a multi-agent reinforcement learning…

Artificial Intelligence · Computer Science 2021-11-23 Tobias Müller , Christoph Roch , Kyrill Schmid , Philipp Altmann

This paper presents a hybrid approach to predict the evolution of technological maturity in R and D projects, using the oil and gas sector as an example. Integrating System Dynamics (SD) and Agent Based Modelling (ABM) allows the proposed…

Multiagent Systems · Computer Science 2025-10-14 R. W. S. Pessoa , M. H. Næss , J. C. Bijos , C. M. Rebello , D. Colombo , L. Schnitman , I. B. R. Nogueira

This paper describes a formalization of agent-based models (ABMs) as random walks on regular graphs and relates the symmetry group of those graphs to a coarse-graining of the ABM that is still Markovian. An ABM in which $N$ agents can be in…

Multiagent Systems · Computer Science 2014-10-24 Sven Banisch