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Cell motility underlies many biological processes, including cancer metastasis, bacterial infection, and evolutionary adaptation. We introduce a non-equilibrium single-cell motility model inspired by the generalized Langevin equation, which…

Biological Physics · Physics 2026-01-27 Anton Klimek , Prince V. Baruah , Prerna Sharma , Roland R. Netz

In this paper we propose a generalized model for the motion of a two-species self-driven objects ranging from a scenario of a completely random environment of particles of negligible excluded volume to a more deterministic regime of rigid…

Statistical Mechanics · Physics 2019-05-08 Roberto da Silva , Eduardo V. Stock

A lattice model for active matter is studied numerically, showing that it displays wettings transitions between three distinctive phases when in contact with an impenetrable wall. The particles in the model move persistently, tumbling with…

Soft Condensed Matter · Physics 2017-09-13 Néstor Sepúlveda , Rodrigo Soto

Motivated by observations of the dynamics of {\it Myxococcus xanthus}, we present a self-interacting random walk model that describes the competition between chemokinesis and chemotaxis. Cells are constrained to move in one dimension, but…

Statistical Mechanics · Physics 2016-08-31 Maria R. D'Orsogna , Marc Suchard , Tom Chou

We present a novel mathematical model of heterogeneous cell proliferation where the total population consists of a subpopulation of slow-proliferating cells and a subpopulation of fast-proliferating cells. The model incorporates two…

Cell Behavior · Quantitative Biology 2021-11-04 Sean T. Vittadello , Scott W. McCue , Gency Gunasingh , Nikolas K. Haass , Matthew J. Simpson

The accumulation of swimming bacteria near surfaces may lead to biological processes such as biofilm formation and wound infection. Previous experimental observations of Vibrio alginolyticus showed an interesting correlation between the…

Biological Physics · Physics 2023-07-04 Vahid Nourian , Henry Shum

We examine the budding of a nanoscale particle through a lipid bilayer using molecular dynamics simulations, free energy calculations, and an elastic theory, with the aim of determining the extent to which equilibrium elasticity theory can…

Subcellular Processes · Quantitative Biology 2012-02-22 Teresa Ruiz-Herrero , Enrique Velasco , Michael F. Hagan

Standard models of population dynamics focus on the the interaction, survival, and extinction of the competing species individually. Real ecological systems, however, are characterized by an abundance of species (or strategies, in the…

Populations and Evolution · Quantitative Biology 2014-05-27 Alexander Dobrinevski , Mikko Alava , Tobias Reichenbach , Erwin Frey

We have experimentally investigated the transitions of collective motions of bacterial cells in a shallow circular pool using the bacterial species $Bacillus$ $subtilis$. In our previous paper, we reported that the collective motions were…

Biological Physics · Physics 2020-07-21 Ryojiro Honda , Sora Umeda , Jun-ichi Wakita

Spreading processes on top of active dynamics provide a novel theoretical framework for capturing emerging collective behavior in living systems. I consider run-and-tumble dynamics coupled with coagulation/decoagulation reactions that lead…

Statistical Mechanics · Physics 2025-05-29 Matteo Paoluzzi

We numerically examine the transport of an assembly of active run-and-tumble disks interacting with a traveling wave substrate. We show that as a function of substrate strength, wave speed, disk activity, and disk density, a variety of…

Soft Condensed Matter · Physics 2017-01-25 Cs. Sándor , A. Libál , C. Reichhardt , C. J. Olson Reichhardt

We study the meandering instability during growth of an isolated nanostructure, a crystalline cone, consisting of concentric circular steps. The onset of the instability is studied analytically within the framework of the standard…

Materials Science · Physics 2009-11-07 M. Rusanen , I. T. Koponen , T. Ala-Nissila

This paper concerns a model for tumor cell migration through the surrounding extracellular matrix by considering mass balance phenomena involving the chemical interactions produced on the cell surface. The well-posedness of this model is…

Analysis of PDEs · Mathematics 2015-09-03 J. Nieto , L. Urrutia

We study the shock structures in three-states one-dimensional driven-diffusive systems with nearest neighbors interactions using a matrix product formalism. We consider the cases in which the stationary probability distribution function of…

Statistical Mechanics · Physics 2009-11-11 F H Jafarpour , S R Masharian

When it comes to active particles, even an ideal-gas model in a harmonic potential poses a mathematical challenge. An exception is a run-and-tumble model (RTP) in one-dimension for which a stationary distribution is known exactly. The case…

Statistical Mechanics · Physics 2023-09-25 Derek Frydel

A cellular bleb grows when a portion of the cell membrane detaches from the underlying cortex under the influence of a cytoplasmic pressure. We develop a quantitative model for the growth and dynamics of these objects in a simple…

Biological Physics · Physics 2015-06-05 Fong Yin Lim , Keng-Hwee Chiam , L. Mahadevan

We study a model of interacting run-and-tumble random walkers operating under mutual hardcore exclusion on a one-dimensional lattice with periodic boundary conditions. We incorporate a finite, Poisson-distributed, tumble duration so that a…

Statistical Mechanics · Physics 2017-08-18 A. B. Slowman , M. R. Evans , R. A. Blythe

We consider the motion of red blood cells and other non-spherical microcapsules dilutely suspended in a simple shear flow. Our analysis indicates that depending on the viscosity, membrane elasticity, geometry and shear rate, the particle…

Soft Condensed Matter · Physics 2015-06-25 J. M. Skotheim , T. W. Secomb

The spreading of bacterial populations is central to processes in agriculture, the environment, and medicine. However, existing models of spreading typically focus on cells in unconfined settings--despite the fact that many bacteria inhabit…

Populations and Evolution · Quantitative Biology 2022-06-07 Daniel B. Amchin , Jenna A. Ott , Tapomoy Bhattacharjee , Sujit S. Datta

Contact inhibition plays a crucial role in the motility of cells, the process of wound healing, and the formation of tumors. By mimicking the mechanical motion of calls crawling on a substrate using a pseudopod, we constructed a minimal…

Soft Condensed Matter · Physics 2016-11-28 Simon Kaspar Schnyder , Yuki Tanaka , John Jairo Molina , Ryoichi Yamamoto