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Recent emergence of next-generation DNA sequencing technology has enabled acquisition of genetic information at unprecedented scales. In order to determine the genetic blueprint of an organism, sequencing platforms typically employ…

Genomics · Quantitative Biology 2015-06-19 Xiaohu Shen , Manohar Shamaiah , Haris Vikalo

The majority of model-based learned image reconstruction methods in medical imaging have been limited to uniform domains, such as pixelated images. If the underlying model is solved on nonuniform meshes, arising from a finite element method…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 William Herzberg , Daniel B. Rowe , Andreas Hauptmann , Sarah J. Hamilton

The prevalent technique for DNA sequencing consists of two main steps: shotgun sequencing, where many randomly located fragments, called reads, are extracted from the overall sequence, followed by an assembly algorithm that aims to…

Genomics · Quantitative Biology 2016-01-28 Shirshendu Ganguly , Elchanan Mossel , Miklos Z. Racz

This paper addresses the problem of 3D human pose and shape estimation from a single image. Previous approaches consider a parametric model of the human body, SMPL, and attempt to regress the model parameters that give rise to a mesh…

Computer Vision and Pattern Recognition · Computer Science 2019-05-09 Nikos Kolotouros , Georgios Pavlakos , Kostas Daniilidis

In this paper, we study the problem of learning Graph Convolutional Networks (GCNs) for regression. Current architectures of GCNs are limited to the small receptive field of convolution filters and shared transformation matrix for each…

Computer Vision and Pattern Recognition · Computer Science 2020-03-10 Long Zhao , Xi Peng , Yu Tian , Mubbasir Kapadia , Dimitris N. Metaxas

Heterogeneous Graph Neural Networks (HGNNs) have gained significant popularity in various heterogeneous graph learning tasks. However, most existing HGNNs rely on spatial domain-based methods to aggregate information, i.e., manually…

Machine Learning · Computer Science 2024-05-08 Mingguo He , Zhewei Wei , Shikun Feng , Zhengjie Huang , Weibin Li , Yu Sun , Dianhai Yu

Whole brain segmentation using deep learning (DL) is a very challenging task since the number of anatomical labels is very high compared to the number of available training images. To address this problem, previous DL methods proposed to…

Image and Video Processing · Electrical Eng. & Systems 2019-11-22 Pierrick Coupé , Boris Mansencal , Michaël Clément , Rémi Giraud , Baudouin Denis de Senneville , Vinh-Thong Ta , Vincent Lepetit , José V. Manjon

The computational problem of inferring the full haplotype of a cell starting from read sequencing data is known as haplotype assembly, and consists in assigning all heterozygous Single Nucleotide Polymorphisms (SNPs) to exactly one of the…

We present an end-to-end deep learning segmentation method by combining a 3D UNet architecture with a graph neural network (GNN) model. In this approach, the convolutional layers at the deepest level of the UNet are replaced by a GNN-based…

Image and Video Processing · Electrical Eng. & Systems 2019-08-26 Antonio Garcia-Uceda Juarez , Raghavendra Selvan , Zaigham Saghir , Marleen de Bruijne

Reconstructing a map of neuronal connectivity is a critical challenge in contemporary neuroscience. Recent advances in high-throughput serial section electron microscopy (EM) have produced massive 3D image volumes of nanoscale brain tissue…

In this paper, we propose a semi-supervised deep learning method for detecting the specific types of reads that impede the de novo genome assembly process. Instead of dealing directly with sequenced reads, we analyze their coverage graphs…

Machine Learning · Computer Science 2019-04-24 Tomislav Šebrek , Jan Tomljanović , Josip Krapac , Mile Šikić

Biological processes underlying the basic functions of a cell involve complex interactions between genes. From a technical point of view, these interactions can be represented through a graph where genes and their connections are,…

Methodology · Statistics 2020-11-24 Thi Kim Hue Nguyen , Monica Chiogna

Graph representation learning methods are highly effective in handling complex non-Euclidean data by capturing intricate relationships and features within graph structures. However, traditional methods face challenges when dealing with…

Machine Learning · Computer Science 2025-02-25 Hang Gao , Chenhao Zhang , Fengge Wu , Junsuo Zhao , Changwen Zheng , Huaping Liu

The integration of multi-omic data is pivotal for understanding complex diseases, but its high dimensionality and noise present significant challenges. Graph Neural Networks (GNNs) offer a robust framework for analyzing large-scale…

Quantitative Methods · Quantitative Biology 2024-12-23 Heming Zhang , Di Huang , Yixin Chen , Fuhai Li

In graph signal processing, learning the weighted connections between nodes from a set of sample signals is a fundamental task when the underlying relationships are not known a priori. This task is typically addressed by finding a graph…

Machine Learning · Computer Science 2025-06-30 Benjamin T. Brown , Haoxiang Zhang , Daniel L. Lau , Gonzalo R. Arce

We introduce a novel approach to graph-level representation learning, which is to embed an entire graph into a vector space where the embeddings of two graphs preserve their graph-graph proximity. Our approach, UGRAPHEMB, is a general…

Machine Learning · Computer Science 2019-06-04 Yunsheng Bai , Hao Ding , Yang Qiao , Agustin Marinovic , Ken Gu , Ting Chen , Yizhou Sun , Wei Wang

Image guided depth completion aims to recover per-pixel dense depth maps from sparse depth measurements with the help of aligned color images, which has a wide range of applications from robotics to autonomous driving. However, the 3D…

Computer Vision and Pattern Recognition · Computer Science 2022-10-20 Xin Liu , Xiaofei Shao , Bo Wang , Yali Li , Shengjin Wang

Accurate feature matching and correspondence in endoscopic images play a crucial role in various clinical applications, including patient follow-up and rapid anomaly localization through panoramic image generation. However, developing…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Manel Farhat , Achraf Ben-Hamadou

Deep convolutional neural networks (CNNs) have shown excellent performance in object recognition tasks and dense classification problems such as semantic segmentation. However, training deep neural networks on large and sparse datasets is…

Computer Vision and Pattern Recognition · Computer Science 2017-12-25 Lorenz Berger , Eoin Hyde , M. Jorge Cardoso , Sebastien Ourselin

Over the past decade, neural networks have been successful at making predictions from biological sequences, especially in the context of regulatory genomics. As in other fields of deep learning, tools have been devised to extract features…

Genomics · Quantitative Biology 2022-12-27 Antoine Villié , Philippe Veber , Yohann de Castro , Laurent Jacob
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