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We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

Variational auto-encoders (VAEs) are a popular and powerful deep generative model. Previous works on VAEs have assumed a factorized likelihood model, whereby the output uncertainty of each pixel is assumed to be independent. This…

Machine Learning · Statistics 2026-05-14 Gara Dorta , Sara Vicente , Lourdes Agapito , Neill D. F. Campbell , Ivor Simpson

Our perceptions are guided both by the bottom-up information entering our eyes, as well as our top-down expectations of what we will see. Although bottom-up visual processing has been extensively studied, comparatively little is known about…

Computer Vision and Pattern Recognition · Computer Science 2014-11-20 Michelle R. Greene , Abraham P. Botros , Diane M. Beck , Li Fei-Fei

Neural Networks play a growing role in many science disciplines, including physics. Variational Autoencoders (VAEs) are neural networks that are able to represent the essential information of a high dimensional data set in a low dimensional…

Machine Learning · Statistics 2021-12-08 Johannes Zacherl , Philipp Frank , Torsten A. Enßlin

We present an autoencoder that leverages learned representations to better measure similarities in data space. By combining a variational autoencoder with a generative adversarial network we can use learned feature representations in the…

Machine Learning · Computer Science 2016-02-12 Anders Boesen Lindbo Larsen , Søren Kaae Sønderby , Hugo Larochelle , Ole Winther

Variational Autoencoders (VAEs) have become a popular approach for dimensionality reduction. However, despite their ability to identify latent low-dimensional structures embedded within high-dimensional data, these latent representations…

Machine Learning · Statistics 2020-08-27 Kaspar Märtens , Christopher Yau

We investigate the problem of producing diverse solutions to an image super-resolution problem. From a probabilistic perspective, this can be done by sampling from the posterior distribution of an inverse problem, which requires the…

Computer Vision and Pattern Recognition · Computer Science 2024-01-10 Jean Prost , Antoine Houdard , Andrés Almansa , Nicolas Papadakis

We propose a novel approach to image classification inspired by complex nonlinear biological visual processing, whereby classical convolutional neural networks (CNNs) are equipped with learnable higher-order convolutions. Our model…

Computer Vision and Pattern Recognition · Computer Science 2025-12-03 Simone Azeglio , Olivier Marre , Peter Neri , Ulisse Ferrari

Variational autoencoders (VAE) represent a popular, flexible form of deep generative model that can be stochastically fit to samples from a given random process using an information-theoretic variational bound on the true underlying…

Machine Learning · Computer Science 2019-10-08 Bin Dai , Yu Wang , John Aston , Gang Hua , David Wipf

Retinal image of surrounding objects varies tremendously due to the changes in position, size, pose, illumination condition, background context, occlusion, noise, and nonrigid deformations. But despite these huge variations, our visual…

Computer Vision and Pattern Recognition · Computer Science 2017-02-14 Saeed Reza Kheradpisheh , Mohammad Ganjtabesh , Timothée Masquelier

Variational Auto-encoders (VAEs) are deep generative latent variable models consisting of two components: a generative model that captures a data distribution p(x) by transforming a distribution p(z) over latent space, and an inference…

Machine Learning · Computer Science 2022-08-25 Yaniv Yacoby , Weiwei Pan , Finale Doshi-Velez

This work studies the problem of modeling visual processes by leveraging deep generative architectures for learning linear, Gaussian representations from observed sequences. We propose a joint learning framework, combining a vector…

Neural and Evolutionary Computing · Computer Science 2020-04-13 Alexander Sagel , Hao Shen

This paper presents a novel generative model for Computer Aided Design (CAD) that 1) represents high-level design concepts of a CAD model as a three-level hierarchical tree of neural codes, from global part arrangement down to local curve…

Computer Vision and Pattern Recognition · Computer Science 2023-07-04 Xiang Xu , Pradeep Kumar Jayaraman , Joseph G. Lambourne , Karl D. D. Willis , Yasutaka Furukawa

In the field of machine learning, it is still a critical issue to identify and supervise the learned representation without manually intervening or intuition assistance to extract useful knowledge or serve for the downstream tasks. In this…

Machine Learning · Computer Science 2025-12-10 Shiqi Liu , Jingxin Liu , Qian Zhao , Xiangyong Cao , Huibin Li , Deyu Meng , Hongying Meng , Sheng Liu

Understanding relationships across multiple imaging modalities is central to neuroimaging research. We introduce the Integrative Variational Autoencoder (InVA), the first hierarchical VAE framework for image-on-image regression in…

Image and Video Processing · Electrical Eng. & Systems 2025-09-15 Bowen Lei , Yeseul Jeon , Rajarshi Guhaniyogi , Aaron Scheffler , Bani Mallick , Alzheimer's Disease Neuroimaging Initiatives

Variational autoencoders (VAEs) have received much attention recently as an end-to-end architecture for text generation with latent variables. In this paper, we investigate several multi-level structures to learn a VAE model to generate…

Computation and Language · Computer Science 2019-06-21 Dinghan Shen , Asli Celikyilmaz , Yizhe Zhang , Liqun Chen , Xin Wang , Jianfeng Gao , Lawrence Carin

Learning useful representations without supervision remains a key challenge in machine learning. In this paper, we propose a simple yet powerful generative model that learns such discrete representations. Our model, the Vector…

Machine Learning · Computer Science 2018-05-31 Aaron van den Oord , Oriol Vinyals , Koray Kavukcuoglu

Predictive coding is a unifying framework for understanding perception, action and neocortical organization. In predictive coding, different areas of the neocortex implement a hierarchical generative model of the world that is learned from…

Neurons and Cognition · Quantitative Biology 2023-05-22 Linxing Preston Jiang , Rajesh P. N. Rao

Multi-view data from the same source often exhibit correlation. This is mirrored in correlation between the latent spaces of separate variational autoencoders (VAEs) trained on each data-view. A multi-view VAE approach is proposed that…

Machine Learning · Statistics 2025-08-01 Ella S. C. Orme , Marina Evangelou , Ulrich Paquet

Learning the latent representation of data in unsupervised fashion is a very interesting process that provides relevant features for enhancing the performance of a classifier. For speech emotion recognition tasks, generating effective…

Sound · Computer Science 2020-07-29 Siddique Latif , Rajib Rana , Junaid Qadir , Julien Epps