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Image-based computational models of the heart represent a powerful tool to shed new light on the mechanisms underlying physiological and pathological conditions in cardiac function and to improve diagnosis and therapy planning. However, in…

Tissues and Organs · Quantitative Biology 2021-01-15 Laura Marx , Justyna A. Niestrawska , Matthias A. F. Gsell , Federica Caforio , Gernot Plank , Christoph M. Augustin

This study proposes an end-to-end unsupervised diffeomorphic deformable registration framework based on moving mesh parameterization. Using this parameterization, a deformation field can be modeled with its transformation Jacobian…

Image and Video Processing · Electrical Eng. & Systems 2022-08-30 Ameneh Sheikhjafari , Deepa Krishnaswamy , Michelle Noga , Nilanjan Ray , Kumaradevan Punithakumar

The clinical application of patient-specific modelling of the heart can provide valuable insights in supplementing and advancing methods of diagnosis as well as helping to devise the best possible therapeutic approach for each individual…

Medical Physics · Physics 2023-08-03 Sebastian Skatulla , Carlo Sansour , Mary Familusi , Jagir Hussan , Ntobeko Ntusi

Cardiopulmonary exercise testing (CPET) provides a comprehensive assessment of functional capacity by measuring key physiological variables including oxygen consumption ($VO_2$), carbon dioxide production ($VCO_2$), and pulmonary…

Machine Learning · Computer Science 2025-03-19 Muhammet Alkan , Gruschen Veldtman , Fani Deligianni

Myocardial infarction causes myocardium thinning, fibrosis, and progressive heart failure. Engineered human myocardium (EHM) is tested clinically as a first-in-class product for sustainable remuscularization in patients with advanced heart…

Medical Physics · Physics 2025-08-28 Hossein Goodarzi Hosseinabadi

The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and frictionless sliding of the myocardium.…

Computational Engineering, Finance, and Science · Computer Science 2018-12-11 Martin R. Pfaller , Julia M. Hörmann , Martina Weigl , Andreas Nagler , Radomir Chabiniok , Cristóbal Bertoglio , Wolfgang A. Wall

Electroanatomic mapping as routinely acquired in ablation therapy of ventricular tachycardia is the gold standard method to identify the arrhythmogenic substrate. To reduce the acquisition time and still provide maps with high spatial…

In this paper, a robust sinusoidal model fitting method based on the Differential Evolution (DE) algorithm for determining cardiopulmonary resuscitation (CPR) quality-parameters - naming chest compression frequency and depth - as measured…

Medical Physics · Physics 2019-02-18 Christian Lins , Andreas Klausen , Sandra Hellmers , Andreas Hein , Sebastian Fudickar

Large prospective epidemiological studies acquire cardiovascular magnetic resonance (CMR) images for pre-symptomatic populations and follow these over time. To support this approach, fully automatic large-scale 3D analysis is essential. In…

Image and Video Processing · Electrical Eng. & Systems 2019-07-04 Rahman Attar , Marco Pereanez , Christopher Bowles , Stefan K. Piechnik , Stefan Neubauer , Steffen E. Petersen , Alejandro F. Frangi

A significant hallmark of hypertrophic cardiomyopathy (HCM) is fiber disarray, which is associated with various cardiac events such as heart failure. Quantifying fiber disarray remains critical for understanding the disease s complex…

Tissues and Organs · Quantitative Biology 2025-07-04 Mohammad Mehri , Kenneth S. Campbell , Lik Chuan Lee , Jonathan F. Wenk

Cardiac magnetic resonance (CMR) sequences visualise the cardiac function voxel-wise over time. Simultaneously, deep learning-based deformable image registration is able to estimate discrete vector fields which warp one time step of a CMR…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Sven Koehler , Tarique Hussain , Hamza Hussain , Daniel Young , Samir Sarikouch , Thomas Pickhardt , Gerald Greil , Sandy Engelhardt

In this paper, we propose a new deep learning framework for an automatic myocardial infarction evaluation from clinical information and delayed enhancement-MRI (DE-MRI). The proposed framework addresses two tasks. The first task is…

Image and Video Processing · Electrical Eng. & Systems 2020-11-02 Kibrom Berihu Girum , Youssef Skandarani , Raabid Hussain , Alexis Bozorg Grayeli , Gilles Créhange , Alain Lalande

Myocardial motion and deformation are rich descriptors that characterize cardiac function. Image registration, as the most commonly used technique for myocardial motion tracking, is an ill-posed inverse problem which often requires prior…

Image and Video Processing · Electrical Eng. & Systems 2022-06-09 Chen Qin , Shuo Wang , Chen Chen , Wenjia Bai , Daniel Rueckert

Coronary angioplasty with stent implantation is the most frequently used interventional treatment for coronary artery disease. However, reocclusion within the stent, referred to as in-stent restenosis, occurs in up to 10% of lesions. It is…

Computational Engineering, Finance, and Science · Computer Science 2025-02-19 Janina C. Datz , Ivo Steinbrecher , Christoph Meier , Nora Hagmeyer , Leif-Christopher Engel , Alexander Popp , Martin R. Pfaller , Heribert Schunkert , Wolfgang A. Wall

Cardiac magnetic resonance imaging (CMR) is vital for diagnosing heart diseases, but long scan time remains a major drawback. To address this, accelerated imaging techniques have been introduced by undersampling k-space, which reduces the…

Computer Vision and Pattern Recognition · Computer Science 2025-02-24 Donghang Lyu , Chinmay Rao , Marius Staring , Matthias J. P. van Osch , Mariya Doneva , Hildo J. Lamb , Nicola Pezzotti

Understanding the biomechanics of the heart in health and disease plays an important role in the diagnosis and treatment of heart failure. The use of computational biomechanical models for therapy assessment is paving the way for…

The study of pathological cardiac conditions such as arrhythmias, a major cause of mortality in heart failure, is becoming increasingly informed by computational simulation, numerically modelling the governing equations. This can provide…

Computational Engineering, Finance, and Science · Computer Science 2014-06-09 Nathan Kirk , Alan Benson , Christopher Goodyer , Matthew Hubbard

Background: Quantitative stress perfusion cardiovascular magnetic resonance (CMR) is a powerful tool for assessing myocardial ischemia. Motion correction is essential for accurate pixel-wise mapping but traditional registration-based…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Noortje I. P. Schueler , Nathan C. K. Wong , Richard J. Crawley , Josien P. W. Pluim , Amedeo Chiribiri , Cian M. Scannell

Ventricular fibrillation, the major reason behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular disturbances in the spatiotemporal electrical activation of the heart makes it incapable of any…

Chaotic Dynamics · Physics 2009-11-07 Sitabhra Sinha , Ashwin Pande , Rahul Pandit

Myocardial infarction (MI), commonly known as a heart attack, is a critical health condition caused by restricted blood flow to the heart. Early-stage detection through continuous ECG monitoring is essential to minimize irreversible damage.…

Machine Learning · Computer Science 2024-11-28 Abhijith S , Arjun Rajesh , Mansi Manoj , Sandra Davis Kollannur , Sujitta R , Jerrin Thomas Panachakel