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Deep neural networks excel in mapping genomic DNA sequences to associated readouts (e.g., protein-DNA binding). Beyond prediction, the goal of these networks is to reveal to scientists the underlying motifs (and their syntax) which drive…

Genomics · Quantitative Biology 2024-10-10 Alex M. Tseng , Gokcen Eraslan , Tommaso Biancalani , Gabriele Scalia

The gamma belief network (GBN), often regarded as a deep topic model, has demonstrated its potential for uncovering multi-layer interpretable latent representations in text data. Its notable capability to acquire interpretable latent…

Machine Learning · Computer Science 2024-08-16 Zhibin Duan , Tiansheng Wen , Muyao Wang , Bo Chen , Mingyuan Zhou

In a context of constant increase in competition and heightened regulatory pressure, accuracy, actuarial precision, as well as transparency and understanding of the tariff, are key issues in non-life insurance. Traditionally used…

Applications · Statistics 2025-03-28 Markéta Krùpovà , Nabil Rachdi , Quentin Guibert

As deep neural networks continue to revolutionize various application domains, there is increasing interest in making these powerful models more understandable and interpretable, and narrowing down the causes of good and bad predictions. We…

Machine Learning · Statistics 2016-10-04 Viktoriya Krakovna , Finale Doshi-Velez

Data-driven surrogate modeling has surged in capability in recent years with the emergence of graph neural networks (GNNs), which can operate directly on mesh-based representations of data. The goal of this work is to introduce an…

Machine Learning · Computer Science 2024-10-25 Shivam Barwey , Hojin Kim , Romit Maulik

Deep learning models have great potential in medical imaging, including orthodontics and skeletal maturity assessment. However, applying a model to data different from its training set can lead to unreliable predictions that may impact…

Image and Video Processing · Electrical Eng. & Systems 2025-05-15 Omid Halimi Milani , Amanda Nikho , Lauren Mills , Marouane Tliba , Ahmet Enis Cetin , Mohammed H. Elnagar

Relational databases are the de facto standard for storing and querying structured data, and extracting insights from structured data requires advanced analytics. Deep neural networks (DNNs) have achieved super-human prediction performance…

Machine Learning · Computer Science 2021-07-06 Shaofeng Cai , Kaiping Zheng , Gang Chen , H. V. Jagadish , Beng Chin Ooi , Meihui Zhang

The trade-off between interpretability and accuracy remains a core challenge in machine learning. Standard Generalized Additive Models (GAMs) offer clear feature attributions but are often constrained by their strictly additive nature,…

Machine Learning · Computer Science 2026-02-12 Guangzhi Xiong , Sanchit Sinha , Aidong Zhang

Recent advancements in graph learning have revolutionized the way to understand and analyze data with complex structures. Notably, Graph Neural Networks (GNNs), i.e. neural network architectures designed for learning graph representations,…

Machine Learning · Computer Science 2024-07-09 Yu Huang , Min Zhou , Menglin Yang , Zhen Wang , Muhan Zhang , Jie Wang , Hong Xie , Hao Wang , Defu Lian , Enhong Chen

Mechanistic interpretability aims to reverse engineer neural networks by uncovering which high-level algorithms they implement. Causal abstraction provides a precise notion of when a network implements an algorithm, i.e., a causal model of…

Machine Learning · Computer Science 2025-03-17 Theodora-Mara Pîslar , Sara Magliacane , Atticus Geiger

Diffusion models have shown remarkable performance on many generative tasks. Despite recent success, most diffusion models are restricted in that they only allow linear transformation of the data distribution. In contrast, broader family of…

Machine Learning · Computer Science 2024-06-04 Grigory Bartosh , Dmitry Vetrov , Christian A. Naesseth

Graph neural networks (GNNs) are powerful graph-based deep-learning models that have gained significant attention and demonstrated remarkable performance in various domains, including natural language processing, drug discovery, and…

Machine Learning · Computer Science 2023-06-06 Jaykumar Kakkad , Jaspal Jannu , Kartik Sharma , Charu Aggarwal , Sourav Medya

Massive language models are the core of modern NLP modeling and have been shown to encode impressive amounts of commonsense and factual information. However, that knowledge exists only within the latent parameters of the model, inaccessible…

Computation and Language · Computer Science 2020-07-03 Pat Verga , Haitian Sun , Livio Baldini Soares , William W. Cohen

The nonliteral interpretation of a text is hard to be understood by machine models due to its high context-sensitivity and heavy usage of figurative language. In this study, inspired by human reading comprehension, we propose a novel,…

Computation and Language · Computer Science 2020-01-17 Guoxiu He , Zhe Gao , Zhuoren Jiang , Yangyang Kang , Changlong Sun , Xiaozhong Liu , Wei Lu

Contemporary computational neuroscience features two prominent modeling traditions. Bottom-up whole-brain modeling (WBM) builds biophysically detailed simulations of brain structure and dynamics, whereas top-down neuroconnectionism…

Neurons and Cognition · Quantitative Biology 2026-05-19 Mario Senden , Leonardo Dalla Porta , Jan Fousek , Jorge F. Mejias , Gorka Zamora-López

Interpretability is a crucial aspect of machine learning models that enables humans to understand and trust the decision-making process of these models. In many real-world applications, the interpretability of models is essential for legal,…

Machine Learning · Statistics 2023-07-18 Shree Charran R , Sandipan Das Mahapatra

The inherent intractability of probabilistic inference has hindered the application of belief networks to large domains. Noisy OR-gates [30] and probabilistic similarity networks [18, 17] escape the complexity of inference by restricting…

Artificial Intelligence · Computer Science 2013-03-08 Paul Dagum , Adam Galper

Nested Effects Models (NEMs) are a class of graphical models introduced to analyze the results of gene perturbation screens. NEMs explore noisy subset relations between the high-dimensional outputs of phenotyping studies, e.g. the effects…

Quantitative Methods · Quantitative Biology 2010-10-08 Achim Tresch , Florian Markowetz

Inferring temporal interaction graphs and higher-order structure from neural signals is a key problem in building generative models for systems neuroscience. Foundation models for large-scale neural data represent shared latent structures…

Machine Learning · Computer Science 2025-08-26 Nathan X. Kodama , Kenneth A. Loparo

Various Graph Neural Networks (GNNs) have been successful in analyzing data in non-Euclidean spaces, however, they have limitations such as oversmoothing, i.e., information becomes excessively averaged as the number of hidden layers…

Machine Learning · Computer Science 2024-01-23 Jaeyoon Sim , Sooyeon Jeon , InJun Choi , Guorong Wu , Won Hwa Kim