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Filtering algorithms for high-dimensional nonlinear non-Gaussian partially observed stochastic processes provide access to the likelihood function and hence enable likelihood-based or Bayesian inference for this methodologically challenging…

Methodology · Statistics 2025-07-15 Kunyang He , Yize Hao , Edward L. Ionides

Filtering algorithms are fundamental for inference on partially observed stochastic dynamic systems, since they provide access to the likelihood function and hence enable likelihood-based or Bayesian inference. A novel Poisson approximate…

Methodology · Statistics 2024-09-19 Yize Hao , Aaron A. Abkemeier , Edward L. Ionides

An assumed density approximate likelihood is derived for a class of partially observed stochastic compartmental models which permit observational over-dispersion. This is achieved by treating time-varying reporting probabilities as latent…

Methodology · Statistics 2025-05-22 Michael Whitehouse

Traditional compartmental models capture population-level dynamics but fail to characterize individual-level risk. The computational cost of exact likelihood evaluation for partially observed individual-based models, however, grows…

Methodology · Statistics 2026-01-27 Lorenzo Rimella , Nick Whiteley , Chris Jewell , Paul Fearnhead , Michael Whitehouse

This paper formulates a penalized empirical likelihood (PEL) method for inference on the population mean when the dimension of the observations may grow faster than the sample size. Asymptotic distributions of the PEL ratio statistic is…

Statistics Theory · Mathematics 2013-02-28 Soumendra N. Lahiri , Subhodeep Mukhopadhyay

Epidemic models are used to analyze the progression or outcome of an epidemic under different control policies like vaccinations, quarantines, lockdowns, use of face-masks, pharmaceutical interventions, etc. When these models accurately…

Quantitative Methods · Quantitative Biology 2022-04-19 Carlos Hernandez-Suarez , Osval Montsinos Lopez , Ramon Solano-Barajas

Recent pandemics have highlighted the critical role of infectious disease models in guiding public health decision-making, driving demand for realistic models that can provide timely answers under uncertainty. Compartmental models are…

Methodology · Statistics 2026-03-18 Xiahui Li , Fergus J. Chadwick , Ben Swallow

The Poisson log-normal model is a latent variable model that provides a generic framework for the analysis of multivariate count data. Inferring its parameters can be a daunting task since the conditional distribution of the latent…

Computation · Statistics 2026-05-19 Julien Stoehr , Stephane S. Robin

Population dynamics models play an important role in a number of fields, such as actuarial science, demography, and ecology, as they help explain past fluctuations and predict future population. The accuracy of these models is often…

Methodology · Statistics 2025-11-06 Paolo Onorati , Sofia Ruiz-Suarez , Radu Craiu

With a rapid increase in volume and complexity of data sets, there is a need for methods that can extract useful information, for example the relationship between two data sets measured for the same persons. The Partial Least Squares (PLS)…

Bayesian inference methods are useful in infectious diseases modeling due to their capability to propagate uncertainty, manage sparse data, incorporate latent structures, and address high-dimensional parameter spaces. However, parameter…

Methodology · Statistics 2025-04-29 Xiahui Li , Fergus Chadwick , Ben Swallow

A Poisson autoregressive (PAR) model accounting for discreteness and autocorrelation of count time series data is typically estimated in the state-space modelling framework through extended Kalman filter. However, because of the complex…

Methodology · Statistics 2025-03-05 Paolo Victor T. Redondo , Joseph Ryan G. Lansangan , Erniel B. Barrios

Prediction of the progression of an infectious disease outbreak is important for planning and coordinating a response. Differential equations are often used to model an epidemic outbreak's behaviour but are challenging to parameterise.…

Populations and Evolution · Quantitative Biology 2022-03-16 David Wu , Helen Petousis-Harris , Janine Paynter , Vinod Suresh , Oliver J. Maclaren

Epidemiological models have tremendous potential to forecast disease burden and quantify the impact of interventions. Detailed models are increasingly popular, however these models tend to be stochastic and very costly to evaluate.…

Quantitative Methods · Quantitative Biology 2017-08-04 Atiye Alaeddini , Daniel J. Klein

Counting experiments often rely on Monte Carlo simulations for predictions of Poisson expectations. The accompanying uncertainty from the finite Monte Carlo sample size can be incorporated into parameter estimation by modifying the Poisson…

Instrumentation and Methods for Astrophysics · Physics 2020-04-22 Thorsten Glüsenkamp

Population attributable risk (PAR) is used in epidemiology to predict the impact of removing a risk factor from the population. Until recently, no standard approach for calculating confidence intervals or the variance for PAR was available…

Methodology · Statistics 2021-05-28 Sarah Pirikahu , Geoffrey Jones , Martin Hazelton

The probabilities of causation are commonly used to solve decision-making problems. Tian and Pearl derived sharp bounds for the probability of necessity and sufficiency (PNS), the probability of sufficiency (PS), and the probability of…

Artificial Intelligence · Computer Science 2022-10-12 Ang Li , Ruirui Mao , Judea Pearl

We consider the problem of inference for the states and parameters of a continuous-time multitype branching process from partially observed time series data. Exact inference for this class of models, typically using sequential Monte Carlo,…

Methodology · Statistics 2025-12-01 Angus Lewis , Antonio Parrella , John Maclean , Andrew J. Black

Phylodynamics seeks to estimate effective population size fluctuations from molecular sequences of individuals sampled from a population of interest. One way to accomplish this task formulates an observed sequence data likelihood exploiting…

We introduce a new method for inference in stochastic epidemic models which uses recursive multinomial approximations to integrate over unobserved variables and thus circumvent likelihood intractability. The method is applicable to a class…

Methodology · Statistics 2021-02-24 Nick Whiteley , Lorenzo Rimella
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