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A major obstacle to the realization of novel inorganic materials with desirable properties is the inability to perform efficient optimization across both materials properties and synthesis of those materials. In this work, we propose a…

Materials Science · Physics 2022-10-24 Elton Pan , Christopher Karpovich , Elsa Olivetti

This paper proposes a reinforcement learning framework for performance-driven structural design that combines bottom-up design generation with learned strategies to efficiently search large combinatorial design spaces. Motivated by the…

Computational Engineering, Finance, and Science · Computer Science 2025-07-31 Chloe S. H. Hong , Keith J. Lee , Caitlin T. Mueller

Deep learning techniques have been widely applied, achieving state-of-the-art results in various fields of study. This survey focuses on deep learning solutions that target learning control policies for robotics applications. We carry out…

Robotics · Computer Science 2018-04-10 Lei Tai , Jingwei Zhang , Ming Liu , Joschka Boedecker , Wolfram Burgard

The ability to recover from a fall is an essential feature for a legged robot to navigate in challenging environments robustly. Until today, there has been very little progress on this topic. Current solutions mostly build upon…

Robotics · Computer Science 2024-12-20 Joonho Lee , Jemin Hwangbo , Marco Hutter

The physical design of a robot and the policy that controls its motion are inherently coupled, and should be determined according to the task and environment. In an increasing number of applications, data-driven and learning-based…

Robotics · Computer Science 2018-09-18 Charles Schaff , David Yunis , Ayan Chakrabarti , Matthew R. Walter

Molecular property prediction constitutes a cornerstone of drug discovery and materials science, necessitating models capable of disentangling complex structure-property relationships across diverse molecular modalities. Existing approaches…

Machine Learning · Computer Science 2026-03-24 Long Xu , Junping Guo , Jianbo Zhao , Jianbo Lu , Yuzhong Peng

Deep Reinforcement Learning has enabled the learning of policies for complex tasks in partially observable environments, without explicitly learning the underlying model of the tasks. While such model-free methods achieve considerable…

Machine Learning · Computer Science 2017-01-11 Tanmay Shankar , Santosha K. Dwivedy , Prithwijit Guha

Protein analysis tasks arising in healthcare settings often require accurate reasoning under protein sequence constraints, involving tasks such as functional interpretation of disease-related variants, protein-level analysis for clinical…

Artificial Intelligence · Computer Science 2026-03-03 Congying Liu , Taihao Li , Ming Huang , Xingyuan Wei , Peipei Liu , Yiqing Shen , Yanxu Mao , Tiehan Cui

In this paper, a deep reinforcement learning (DRL) method is proposed to address the problem of UAV navigation in an unknown environment. However, DRL algorithms are limited by the data efficiency problem as they typically require a huge…

Robotics · Computer Science 2020-08-07 Lei He , Nabil Aouf , James F. Whidborne , Bifeng Song

Multimodal protein features play a crucial role in protein function prediction. However, these features encompass a wide range of information, ranging from structural data and sequence features to protein attributes and interaction…

Machine Learning · Computer Science 2025-11-07 Xiaoling Luo , Peng Chen , Chengliang Liu , Xiaopeng Jin , Jie Wen , Yumeng Liu , Junsong Wang

A common technique to improve learning performance in deep reinforcement learning (DRL) and many other machine learning algorithms is to run multiple learning agents in parallel. A neglected component in the development of these algorithms…

Machine Learning · Computer Science 2020-03-16 Dhaval Adjodah , Dan Calacci , Abhimanyu Dubey , Anirudh Goyal , Peter Krafft , Esteban Moro , Alex Pentland

Deep Reinforcement Learning (DRL) is a paradigm of artificial intelligence where an agent uses a neural network to learn which actions to take in a given environment. DRL has recently gained traction from being able to solve complex…

Software Engineering · Computer Science 2025-11-03 Rajdeep Singh Hundal , Yan Xiao , Xiaochun Cao , Jin Song Dong , Manuel Rigger

We present a simple, modular graph-based convolutional neural network that takes structural information from protein-ligand complexes as input to generate models for activity and binding mode prediction. Complex structures are generated by…

Biomolecules · Quantitative Biology 2020-02-26 Joseph A. Morrone , Jeffrey K. Weber , Tien Huynh , Heng Luo , Wendy D. Cornell

Molecular Relational Learning (MRL) is widely applied in natural sciences to predict relationships between molecular pairs by extracting structural features. The representational similarity between substructure pairs determines the…

Machine Learning · Computer Science 2026-05-25 Peiliang Zhang , Jingling Yuan , Qing Xie , Yongjun Zhu , Lin Li

This paper introduces a comprehensive framework designed to analyze and secure decision-support systems trained with Deep Reinforcement Learning (DRL), prior to deployment, by providing insights into learned behavior patterns and…

Machine Learning · Computer Science 2025-05-28 Brett Bissey , Kyle Gatesman , Walker Dimon , Mohammad Alam , Luis Robaina , Joseph Weissman

The traveling purchaser problem (TPP) is an important combinatorial optimization problem with broad applications. Due to the coupling between routing and purchasing, existing works on TPPs commonly address route construction and purchase…

Optimization and Control · Mathematics 2025-07-03 Haofeng Yuan , Rongping Zhu , Wanlu Yang , Shiji Song , Keyou You , Wei Fan , C. L. Philip Chen

Robot navigation using deep reinforcement learning (DRL) has shown great potential in improving the performance of mobile robots. Nevertheless, most existing DRL-based navigation methods primarily focus on training a policy that directly…

Robotics · Computer Science 2023-10-23 Wenhao Yu , Jie Peng , Quecheng Qiu , Hanyu Wang , Lu Zhang , Jianmin Ji

One of the long-standing problems in materials science is how to predict a material's structure and then its properties given only its composition. Experimental characterization of crystal structures has been widely used for structure…

Materials Science · Physics 2022-03-29 Rongzhi Dong , Yong Zhao , Yuqi Song , Nihang Fu , Sadman Sadeed Omee , Sourin Dey , Qinyang Li , Lai Wei , Jianjun Hu

While Deep Reinforcement Learning (DRL) provides transformational capabilities to the control of Robotics and Autonomous Systems (RAS), the black-box nature of DRL and uncertain deployment environments of RAS pose new challenges on its…

Robotics · Computer Science 2023-01-16 Yi Dong , Xingyu Zhao , Xiaowei Huang

Protein loop modeling is the most challenging yet highly non-trivial task in protein structure prediction. Despite recent progress, existing methods including knowledge-based, ab initio, hybrid and deep learning (DL) methods fall…

Biomolecules · Quantitative Biology 2023-06-23 Tianyue Wang , Xujun Zhang , Odin Zhang , Peichen Pan , Guangyong Chen , Yu Kang , Chang-Yu Hsieh , Tingjun Hou
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