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As single-cell gene expression data analysis continues to grow, the need for reliable clustering methods has become increasingly important. The prevalence of heuristic means for method choice could lead to inaccurate reports if…

Quantitative Methods · Quantitative Biology 2026-05-19 Owen Visser , Somnath Datta

In general, we can not use algebraic or enumerative methods to optimize a quality control (QC) procedure so as to detect the critical random and systematic analytical errors with stated probabilities, while the probability for false…

Neural and Evolutionary Computing · Computer Science 2018-12-03 Aristides T. Hatjimihail , Theophanes T. Hatjimihail

Many applications of machine learning involve the analysis of large data frames-matrices collecting heterogeneous measurements (binary, numerical, counts, etc.) across samples-with missing values. Low-rank models, as studied by Udell et al.…

Machine Learning · Statistics 2018-12-21 Geneviève Robin , Hoi-To Wai , Julie Josse , Olga Klopp , Éric Moulines

We propose a novel methodology for feature screening in clustering massive datasets, in which both the number of features and the number of observations can potentially be very large. Taking advantage of a fusion penalization based convex…

Methodology · Statistics 2017-10-05 Trambak Banerjee , Gourab Mukherjee , Peter Radchenko

LSTD is a popular algorithm for value function approximation. Whenever the number of features is larger than the number of samples, it must be paired with some form of regularization. In particular, L1-regularization methods tend to perform…

Machine Learning · Computer Science 2012-07-03 Matthieu Geist , Bruno Scherrer , Alessandro Lazaric , Mohammad Ghavamzadeh

Discovery of diagnostic and prognostic molecular markers is important and actively pursued the research field in cancer research. For complex diseases, this process is often performed using Machine Learning. The current study compares two…

Genomics · Quantitative Biology 2020-04-30 Aneta Polewko-Klim , Witold R. Rudnicki

We observe a random measure $N$ and aim at estimating its intensity $s$. This statistical framework allows to deal simultaneously with the problems of estimating a density, the marginals of a multivariate distribution, the mean of a random…

Statistics Theory · Mathematics 2009-05-12 Yannick Baraud

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…

Machine Learning · Computer Science 2014-03-11 Mehdi Naseriparsa , Amir-masoud Bidgoli , Touraj Varaee

A fast forward feature selection algorithm is presented in this paper. It is based on a Gaussian mixture model (GMM) classifier. GMM are used for classifying hyperspectral images. The algorithm selects iteratively spectral features that…

Computer Vision and Pattern Recognition · Computer Science 2015-01-06 Mathieu Fauvel , Clement Dechesne , Anthony Zullo , Frédéric Ferraty

Simulation studies are indispensable for evaluating statistical methods and ubiquitous in statistical research. The most common simulation approach is parametric simulation, where the data-generating mechanism (DGM) corresponds to a…

In this paper, we consider the classic measurement error regression scenario in which our independent, or design, variables are observed with several sources of additive noise. We will show that our motivating example's replicated…

Applications · Statistics 2012-07-10 David J. Biagioni , Ryan Elmore , Wesley Jones

This paper is concerned with an important issue in finite mixture modelling, the selection of the number of mixing components. We propose a new penalized likelihood method for model selection of finite multivariate Gaussian mixture models.…

Methodology · Statistics 2013-01-17 Tao Huang , Heng Peng , Kun Zhang

The discovery of drug-target interactions (DTIs) is a pivotal process in pharmaceutical development. Computational approaches are a promising and efficient alternative to tedious and costly wet-lab experiments for predicting novel DTIs from…

Artificial Intelligence · Computer Science 2023-03-22 Bin Liu , Jin Wang , Kaiwei Sun , Grigorios Tsoumakas

Machine learning models are increasingly used in critical decision-making applications. However, these models are susceptible to replicating or even amplifying bias present in real-world data. While there are various bias mitigation methods…

Machine Learning · Computer Science 2024-01-05 Shih-Chi Ma , Tatiana Ermakova , Benjamin Fabian

Variable selection in cluster analysis is important yet challenging. It can be achieved by regularization methods, which realize a trade-off between the clustering accuracy and the number of selected variables by using a lasso-type penalty.…

Methodology · Statistics 2016-12-23 Marbac Matthieu , Sedki Mohammed

Random forest is effective for prediction tasks but the randomness of tree generation hinders interpretability in feature importance analysis. To address this, we proposed DT-Sampler, a SAT-based method for measuring feature importance in…

Machine Learning · Computer Science 2023-07-26 Chao Huang , Diptesh Das , Koji Tsuda

This paper studies statistical aggregation procedures in regression setting. A motivating factor is the existence of many different methods of estimation, leading to possibly competing estimators. We consider here three different types of…

Statistics Theory · Mathematics 2007-06-13 Florentina Bunea , Alexandre Tsybakov , Marten Wegkamp

Recent advancements in Large Language Models (LLMs) have greatly extended the capabilities of Multi-Agent Systems (MAS), demonstrating significant effectiveness across a wide range of complex and open-ended domains. However, despite this…

Filtering is a general name for inferring the states of a dynamical system given observations. The most common filtering approach is Gaussian Filtering (GF) where the distribution of the inferred states is a Gaussian whose mean is an affine…

Signal Processing · Electrical Eng. & Systems 2018-11-21 Arash Mehrjou , Bernhard Schölkopf

We consider the problem of active learning for global sensitivity analysis of expensive black-box functions. Our aim is to efficiently learn the importance of different input variables, e.g., in vehicle safety experimentation, we study the…

Machine Learning · Computer Science 2024-10-22 Syrine Belakaria , Benjamin Letham , Janardhan Rao Doppa , Barbara Engelhardt , Stefano Ermon , Eytan Bakshy
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