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In recent years, ultra-high dose rate (FLASH) radiotherapy has become a novel cancer treatment technique because of its similar tumor-killing efficacy as conventional particle therapy while significantly protecting normal tissues. However,…

Accelerator Physics · Physics 2025-03-04 X. Ding , S. Ruan , H. Ren , G. Wang , R. H. Zhu , J. C. Yang , H. Zhao

Fast Radio Bursts (FRBs), with a typical duration of 1 ms and 1 Jy flux density at GHz frequencies, have brightness temperatures exceeding 1e33 K, requiring a coherent emission process. This can be achieved by bunching particles in volumes…

High Energy Astrophysical Phenomena · Physics 2016-11-15 Gabriele Ghisellini

Medical synchrotrons are often used for testing instrumentation in high-energy physics or non-clinical research in medical physics. In many applications of medical synchrotrons, such as microdosimetry and ion imaging, precise knowledge of…

Slow resonant extraction from synchrotrons via radio-frequency knock-out is a well-established technique to deliver charged particle beams for various applications. In this contribution, we present explicit analytical expressions for…

Accelerator Physics · Physics 2025-11-12 P. A. Arrutia Sota , E. C. Cortes Garcia , V. A. Sansipersico

A research complex for aerospace radiation effects research has been proposed in Harbin Institute of Technology. Its core part is a proton accelerator complex, which consists of a 10 MeV injector, a 300 MeV synchrotron and beam transport…

Accelerator Physics · Physics 2016-05-27 Yuwen An , Hongfei Ji , Sheng Wang , Liangsheng Huang

Advanced radiotherapy approaches such as FLASH irradiation and spatially fractionated radiotherapy (SFRT) show potential to improve the therapeutic ratio, yet their biological mechanisms and optimal delivery parameters remain uncertain.…

Slow extraction of bunched beams is widely used for mitigating the formation of micro structures due to ripples of the accelerator magnets power supplies on the extracted beam which is also referred to as spill. That helps, in particular,…

Accelerator Physics · Physics 2023-02-01 Stefan Sorge , Peter Forck , Rahul Singh

The FLASH effect, characterized by potential sparing of organs at risk (OAR) through ultra-high dose rate irradiation, has garnered significant attention for its capability to address indications previously untreatable at conventional dose…

Medical Physics · Physics 2024-10-16 S. Wuyckens , M. Chocan Vera , R. Nilsson , V. Wase , D. Di Perri , X. Geets , E. Sterpin , J. A. Lee

One challenge on the path to delivering FLASH-compatible beams with a synchrotron is facilitating an accurate dose-control for the required ultra-high dose rates. We propose the use of pulsed RFKO extraction instead of continuous beam…

Laser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose…

The Circular Electron-Positron Collider (CEPC) can also work as a powerful and excellent synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical…

Medical Physics · Physics 2024-07-23 Junyu Zhang , Xiangyu Wu , Pengyuan Qi , Jike Wang

The purpose of this study was to investigate the feasibility of extracting proton beams with two distinct energies within a single synchrotron cycle. The energy difference between the beams should be sufficient to use one beam as a range…

Accelerator Physics · Physics 2025-06-25 Alexander A. Pryanichnikov , Dmitry Shwartz , Jon Feldmand , Joao Seco , Maria Francesca Spadea

Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultrahigh dose rates. Methods: PSI Gantry 1 treated patients…

Recently, shoot-through proton FLASH has been proposed where the highest energy is extracted from the cyclotron to maximize the dose rate (DR). Even though our proton pencil beam scanning system can deliver 250 MeV (the highest energy), it…

Medical Physics · Physics 2023-01-26 Serdar Charyyev , Chih-Wei Chang , Mingyao Zhu , Liyong Lin , Katja Langen , Anees Dhabaan

A recent study [1] has introduced an advanced method aimed at extracting from a circular particle accelerator over millions of turns using stable islands and a bent crystal. This technique leverages the strength of non-linear beam dynamics…

Purpose: In this study, procedures were developed to achieve efficient reversible conversion of a clinical linear accelerator (LINAC) and deliver electron FLASH (eFLASH) or conventional beams to the treatment room isocenter. Material &…

Short bunch proton beams are of great significance for the applications of white neutron beams and muon beams. The accelerator complex of China Spallation Neutron Source (CSNS) was designed to support the applications mainly based on…

Accelerator Physics · Physics 2022-02-09 Linhao Zhang , Yukai Chen , Jingyu Tang , Xiao Li , Yang Liu , Liangsheng Huang

Crossing a horizontal nonlinear resonance is the approach that can be used to split a beam in several beamlets with the goal to perform multi-turn extraction from a circular particle accelerator. Such an approach has been successfully…

Accelerator Physics · Physics 2022-11-29 G. Russo , F. Cerutti , L. S. Esposito , G. Franchetti , M. Giovannozzi , J. R. Hunt , A. Huschauer

FLASH Radiotherapy (RT) is a potentially new cancer radiotherapy technique where an entire therapeutic dose is delivered in about 0.1 s and at ~1000 times higher dose rate than in conventional RT. For clinical trials to be conducted safely,…

Fast radio bursts (FRB) can arise from synchrotron maser emission at ultra-relativistic magnetized shocks, such as produced by flare ejecta from young magnetars. We combine PIC simulation results for the synchrotron maser with the dynamics…

High Energy Astrophysical Phenomena · Physics 2019-04-10 Brian D. Metzger , Ben Margalit , Lorenzo Sironi
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