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Explaining deep learning models is essential for clinical integration of medical image analysis systems. A good explanation highlights if a model depends on spurious features that undermines generalization and harms a subset of patients or,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-18 Yoni Schirris , Eric Marcus , Jonas Teuwen , Hugo Horlings , Efstratios Gavves

Abundant accumulation of digital histopathological images has led to the increased demand for their analysis, such as computer-aided diagnosis using machine learning techniques. However, digital pathological images and related tasks have…

Computer Vision and Pattern Recognition · Computer Science 2018-02-23 Daisuke Komura , Shumpei Ishikawa

Pathology foundation models have shown strong retrospective performance, but whether such systems can support clinically relevant use remains unclear. This challenge is particularly important in breast cancer, where pathological assessment…

Radiology reporting generative AI holds significant potential to alleviate clinical workloads and streamline medical care. However, achieving high clinical accuracy is challenging, as radiological images often feature subtle lesions and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Yijian Gao , Dominic Marshall , Xiaodan Xing , Junzhi Ning , Giorgos Papanastasiou , Guang Yang , Matthieu Komorowski

With the development of computer-aided diagnosis (CAD) and image scanning technology, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital…

Computer Vision and Pattern Recognition · Computer Science 2021-02-23 Chen Li , Xintong Li , Md Rahaman , Xiaoyan Li , Hongzan Sun , Hong Zhang , Yong Zhang , Xiaoqi Li , Jian Wu , Yudong Yao , Marcin Grzegorzek

For several cancer patients, operative resection with curative intent can end up in early recurrence of the cancer. Current limitations in peri-operative cancer staging and especially intra-operative misidentification of visible metastases…

Image and Video Processing · Electrical Eng. & Systems 2023-06-21 Thomas Schnelldorfer , Janil Castro , Atoussa Goldar-Najafi , Liping Liu

This paper examines how Data Readiness for AI (DRAI) principles apply to leadership-scale scientific datasets used to train foundation models. We analyze archetypal workflows across four representative domains - climate, nuclear fusion,…

Artificial Intelligence · Computer Science 2025-08-01 Wesley Brewer , Patrick Widener , Valentine Anantharaj , Feiyi Wang , Tom Beck , Arjun Shankar , Sarp Oral

Artificial intelligence (AI) has become increasingly central to precision medicine by enabling the integration and interpretation of multimodal data, yet implementation in clinical settings remains limited. This paper provides a scoping…

Artificial Intelligence · Computer Science 2025-10-17 Göktuğ Bender , Samer Faraj , Anand Bhardwaj

Artificial intelligence has become pervasive across disciplines and fields, and biomedical image and signal processing is no exception. The growing and widespread interest on the topic has triggered a vast research activity that is…

Machine Learning · Computer Science 2022-07-12 Guang Yang , Arvind Rao , Christine Fernandez-Maloigne , Vince Calhoun , Gloria Menegaz

More than 3 billion people lack access to care for skin disease. AI diagnostic tools may aid in early skin cancer detection; however most models have not been assessed on images of diverse skin tones or uncommon diseases. To address this,…

Purpose: Most studies evaluating artificial intelligence (AI) models that detect abnormalities in neuroimaging are either tested on unrepresentative patient cohorts or are insufficiently well-validated, leading to poor generalisability to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-10 Siddharth Agarwal , David A. Wood , Mariusz Grzeda , Chandhini Suresh , Munaib Din , James Cole , Marc Modat , Thomas C Booth

Medical Informatics and the application of modern signal processing in the assistance of the diagnostic process in medical imaging is one of the more recent and active research areas today. This thesis addresses a variety of issues related…

Computer Vision and Pattern Recognition · Computer Science 2009-10-20 Harris Georgiou

One of the challenges facing the adoption of digital pathology workflows for clinical use is the need for automated quality control. As the scanners sometimes determine focus inaccurately, the resultant image blur deteriorates the scanned…

Image and Video Processing · Electrical Eng. & Systems 2018-11-16 Mahdi S. Hosseini , Yueyang Zhang , Lyndon Chan , Konstantinos N. Plataniotis , Jasper A. Z. Brawley-Hayes , Savvas Damaskinos

Areas where Artificial Intelligence (AI) & related fields are finding their applications are increasing day by day, moving from core areas of computer science they are finding their applications in various other domains.In recent times…

Machine Learning · Computer Science 2016-07-19 Sahil Sharma , Vinod Sharma , Atul Sharma

Whole Slide Image (WSI) analysis plays a crucial role in modern digital pathology, enabling large-scale feature extraction from tissue samples. However, traditional feature extraction pipelines based on tools like CellProfiler often involve…

Image and Video Processing · Electrical Eng. & Systems 2025-01-13 Yuechen Yang , Yu Wang , Tianyuan Yao , Ruining Deng , Mengmeng Yin , Shilin Zhao , Haichun Yang , Yuankai Huo

Alzheimer's Disease (AD) is marked by significant inter-individual variability in its progression, complicating accurate prognosis and personalized care planning. This heterogeneity underscores the critical need for predictive models…

Machine Learning · Computer Science 2025-05-01 Gulsah Hancerliogullari Koksalmis , Bulent Soykan , Laura J. Brattain , Hsin-Hsiung Huang

Designing Artificial Intelligence (AI) solutions that can operate in real-world situations is a highly complex task. Deploying such solutions in the medical domain is even more challenging. The promise of using AI to improve patient care…

Human-Computer Interaction · Computer Science 2021-10-08 Sagi Schein , Greg Arutiunian , Vitaly Burshtein , Gal Sadeh , Michelle Townshend , Bruce Friedman , Shada Sadr-azodi

The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

An important part of Digital Pathology is the analysis of multiple digitised whole slide images from differently stained tissue sections. It is common practice to mount consecutive sections containing corresponding microscopic structures on…

Computer Vision and Pattern Recognition · Computer Science 2018-11-06 Thomas Lampert , Odyssée Merveille , Jessica Schmitz , Germain Forestier , Friedrich Feuerhake , Cédric Wemmert

When dealing with giga-pixel digital pathology in whole-slide imaging, a notable proportion of data records holds relevance during each analysis operation. For instance, when deploying an image analysis algorithm on whole-slide images…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Haoju Leng , Ruining Deng , Shunxing Bao , Dazheng Fang , Bryan A. Millis , Yucheng Tang , Haichun Yang , Xiao Wang , Yifan Peng , Lipeng Wan , Yuankai Huo