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In this paper, the robustness and accuracy of the deep neural network (DNN) was enhanced by introducing the $L_{2,\infty}$ normalization of the weight matrices of the DNN with Relu as the activation function. It is proved that the…

Machine Learning · Statistics 2020-10-13 Lijia Yu , Xiao-Shan Gao

The inflated beta regression model is widely used for modeling continuous proportions with values at the boundaries. Maximum likelihood estimation for these models is well-known for its sensitivity to outliers, which can severely distort…

Methodology · Statistics 2026-05-15 Francisco Felipe Queiroz , Silvia Lopes de Paula Ferrari

Activation in deep neural networks is fundamental to achieving non-linear mappings. Traditional studies mainly focus on finding fixed activations for a particular set of learning tasks or model architectures. The research on flexible…

Neural and Evolutionary Computing · Computer Science 2020-08-20 Renlong Jie , Junbin Gao , Andrey Vasnev , Min-ngoc Tran

Location information is proven to benefit the deep learning models on capturing the manifold structure of target objects, and accordingly boosts the accuracy of medical image segmentation. However, most existing methods encode the location…

Image and Video Processing · Electrical Eng. & Systems 2021-06-29 Quanziang Wang , Renzhen Wang , Yuexiang Li , Kai Ma , Yefeng Zheng , Deyu Meng

This paper studies robust regression in the settings of Huber's $\epsilon$-contamination models. We consider estimators that are maximizers of multivariate regression depth functions. These estimators are shown to achieve minimax rates in…

Statistics Theory · Mathematics 2017-02-16 Chao Gao

This article proposes doubly robust estimators for the average treatment effect on the treated (ATT) in difference-in-differences (DID) research designs. In contrast to alternative DID estimators, the proposed estimators are consistent if…

Econometrics · Economics 2020-05-07 Pedro H. C. Sant'Anna , Jun B. Zhao

Predicting future brain state from a baseline magnetic resonance image (MRI) is a central challenge in neuroimaging and has important implications for studying neurodegenerative diseases such as Alzheimer's disease (AD). Most existing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Ali Farki , Elaheh Moradi , Deepika Koundal , Jussi Tohka

We study ReLU deep neural networks (DNNs) by investigating their connections with the hierarchical basis method in finite element methods. First, we show that the approximation schemes of ReLU DNNs for $x^2$ and $xy$ are composition…

Numerical Analysis · Mathematics 2022-08-09 Juncai He , Lin Li , Jinchao Xu

The purpose of the present paper is to study the computation complexity of deep ReLU neural networks to approximate functions in H\"older-Nikol'skii spaces of mixed smoothness $H_\infty^\alpha(\mathbb{I}^d)$ on the unit cube…

Numerical Analysis · Mathematics 2021-03-02 Dinh Dũng , Van Kien Nguyen , Mai Xuan Thao

Motivated by recent data analyses in biomedical imaging studies, we consider a class of image-on-scalar regression models for imaging responses and scalar predictors. We propose using flexible multivariate splines over triangulations to…

Methodology · Statistics 2021-06-04 Shan Yu , Guannan Wang , Li Wang , Lijian Yang

Fusing structural-functional images of the brain has shown great potential to analyze the deterioration of Alzheimer's disease (AD). However, it is a big challenge to effectively fuse the correlated and complementary information from…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Qiankun Zuo , Junren Pan , Shuqiang Wang

Early clinical assessment of Alzheimer's disease relies on behavior scores that measure a subject's language, memory, and cognitive skills. On the medical imaging side, functional magnetic resonance imaging has provided invaluable insights…

Signal Processing · Electrical Eng. & Systems 2026-04-14 Javier Salazar Cavazos , Maximillian Egan , Krisanne Litinas , Benjamin Hampstead , Scott Peltier

Many classic methods have shown non-local self-similarity in natural images to be an effective prior for image restoration. However, it remains unclear and challenging to make use of this intrinsic property via deep networks. In this paper,…

Computer Vision and Pattern Recognition · Computer Science 2018-12-12 Ding Liu , Bihan Wen , Yuchen Fan , Chen Change Loy , Thomas S. Huang

A class of robust estimators which are obtained from dual representation of $\phi$-divergences, are studied empirically for the normal location model. Members of this class of estimators are compared, and it is found that they are efficient…

Computation · Statistics 2011-08-16 Mohamed Cherfi

The choice of activation function can have a large effect on the performance of a neural network. While there have been some attempts to hand-engineer novel activation functions, the Rectified Linear Unit (ReLU) remains the most…

Machine Learning · Computer Science 2020-04-14 Garrett Bingham , William Macke , Risto Miikkulainen

White matter hyperintensities (WMH) are key imaging markers in cognitive aging, Alzheimer's disease (AD), and related dementias. Although automated methods for WMH segmentation have advanced, most provide only global lesion load and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Julia Machnio , Mads Nielsen , Mostafa Mehdipour Ghazi

Dynamic multilayer networks are frequently used to describe the structure and temporal evolution of multiple relationships among common entities, with applications in fields such as sociology, economics, and neuroscience. However,…

Methodology · Statistics 2026-04-06 Runshi Tang , Runbing Zheng , Anru R. Zhang , Carey E. Priebe

Deep neural networks have led to state-of-the-art results in many medical imaging tasks including Alzheimer's disease (AD) detection based on structural magnetic resonance imaging (MRI) data. However, the network decisions are often…

Quantitative Methods · Quantitative Biology 2019-08-28 Moritz Böhle , Fabian Eitel , Martin Weygandt , Kerstin Ritter

The current methods for diagnosing Alzheimer Disease using Magnetic Resonance Imaging (MRI) have significant limitations. Many previous studies used 2D Transformers to analyze individual brain slices independently, potentially losing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Juan A. Castro-Silva , Maria N. Moreno Garcia , Diego H. Peluffo-Ordoñez

In this work, we evaluate how neural networks with periodic activation functions can be leveraged to reliably compress large multidimensional medical image datasets, with proof-of-concept application to 4D diffusion-weighted MRI (dMRI). In…

Image and Video Processing · Electrical Eng. & Systems 2022-08-04 Matteo Mancini , Derek K. Jones , Marco Palombo