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Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Weakly-supervised classification of histopathology slides is a computationally intensive task, with a typical whole slide image (WSI) containing billions of pixels to process. We propose Discriminative Region Active Sampling for Multiple…

Image and Video Processing · Electrical Eng. & Systems 2023-02-23 Jack Breen , Katie Allen , Kieran Zucker , Geoff Hall , Nicolas M. Orsi , Nishant Ravikumar

As current computing capabilities increase, modern machine learning and computer vision system tend to increase in complexity, mostly by means of larger models and advanced optimization strategies. Although often neglected, in many problems…

Image and Video Processing · Electrical Eng. & Systems 2024-06-07 Adrian Galdran , Miguel A. González Ballester

Whole-slide image (WSI) classification in computational pathology is commonly formulated as slide-level Multiple Instance Learning (MIL) with a single global bag representation. However, slide-level MIL is fundamentally underconstrained:…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Syed Fahim Ahmed , Gnanesh Rasineni , Florian Koehler , Abu Zahid Bin Aziz , Mei Wang , Attila Gyulassy , Brian Summa , J. Quincy Brown , Valerio Pascucci , Shireen Y. Elhabian

Skin cancer is one of the most common types of malignancy, affecting a large population and causing a heavy economic burden worldwide. Over the last few years, computer-aided diagnosis has been rapidly developed and make great progress in…

Computer Vision and Pattern Recognition · Computer Science 2022-03-31 Yongwei Wang , Yuheng Wang , Tim K. Lee , Chunyan Miao , Z. Jane Wang

Access to medical imaging and associated text data has the potential to drive major advances in healthcare research and patient outcomes. However, the presence of Protected Health Information (PHI) and Personally Identifiable Information…

Machine Learning · Statistics 2025-08-01 Kyle Naddeo , Nikolas Koutsoubis , Rahul Krish , Ghulam Rasool , Nidhal Bouaynaya , Tony OSullivan , Raj Krish

The difficulty of processing gigapixel whole slide images (WSIs) in clinical microscopy has been a long-standing barrier to implementing computer aided diagnostic systems. Since modern computing resources are unable to perform computations…

Computer Vision and Pattern Recognition · Computer Science 2020-08-13 Sam Maksoud , Kun Zhao , Peter Hobson , Anthony Jennings , Brian Lovell

The scarcity of annotated data has sparked significant interest in unsupervised pre-training methods that leverage medical reports as auxiliary signals for medical visual representation learning. However, existing research overlooks the…

Computer Vision and Pattern Recognition · Computer Science 2024-02-06 Zhe Li , Laurence T. Yang , Bocheng Ren , Xin Nie , Zhangyang Gao , Cheng Tan , Stan Z. Li

Accurate and timely cancer diagnosis from histopathological slides is vital for effective clinical decision-making. This paper introduces DepViT-CAD, a deployable AI system for multi-class cancer diagnosis in histopathology. At its core is…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Ashkan Shakarami , Lorenzo Nicole , Rocco Cappellesso , Angelo Paolo Dei Tos , Stefano Ghidoni

TomoSAM has been developed to integrate the cutting-edge Segment Anything Model (SAM) into 3D Slicer, a highly capable software platform used for 3D image processing and visualization. SAM is a promptable deep learning model that is able to…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Federico Semeraro , Alexandre Quintart , Sergio Fraile Izquierdo , Joseph C. Ferguson

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Self-supervised learning (SSL) has emerged as a powerful paradigm for medical image representation learning, particularly in settings with limited labeled data. However, existing SSL methods often rely on complex architectures,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Azad Singh , Deepak Mishra

Recent advancements in large-scale Vision Transformers have made significant strides in improving pre-trained models for medical image segmentation. However, these methods face a notable challenge in acquiring a substantial amount of…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Yiqing Wang , Zihan Li , Jieru Mei , Zihao Wei , Li Liu , Chen Wang , Shengtian Sang , Alan Yuille , Cihang Xie , Yuyin Zhou

Background and Objectives: Reproducibility is a major challenge in developing machine learning (ML)-based solutions in computational pathology (CompPath). The NCI Imaging Data Commons (IDC) provides >120 cancer image collections according…

Introduction: Nottingham grading system is a major prognostic factor for invasive breast carcinoma (IBC). Its determination requires the evaluation of the mitotic score (MS) which is subject to low intra- and inter-observer reproducibility.…

This work summarizes the results of the largest skin image analysis challenge in the world, hosted by the International Skin Imaging Collaboration (ISIC), a global partnership that has organized the world's largest public repository of…

Learning good representation of giga-pixel level whole slide pathology images (WSI) for downstream tasks is critical. Previous studies employ multiple instance learning (MIL) to represent WSIs as bags of sampled patches because, for most…

Computer Vision and Pattern Recognition · Computer Science 2022-12-01 Chunyuan Li , Xinliang Zhu , Jiawen Yao , Junzhou Huang

Brain MRI scans are often found in four modalities, consisting of T1-weighted with and without contrast enhancement (T1ce and T1w), T2-weighted imaging (T2w), and Flair. Leveraging complementary information from these different modalities…

Image and Video Processing · Electrical Eng. & Systems 2025-09-22 Bhavesh Sandbhor , Bheeshm Sharma , Balamurugan Palaniappan

The National Cancer Institute (NCI) Image Data Commons (IDC) offers publicly available cancer radiology collections for cloud computing, crucial for developing advanced imaging tools and algorithms. Despite their potential, these…

Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment…

Computers and Society · Computer Science 2018-07-11 Peng Zhang , Jules White , Douglas C. Schmidt , Gunther Lenz , S. Trent Rosenbloom
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