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An understanding how neurological disorders lead to mechanical dysfunction of the esophagus requires knowledge of the neural circuit of the enteric nervous system. Historically, this has been elusive. Here, we present an empirically guided…

Neurons and Cognition · Quantitative Biology 2024-03-04 Guy Elisha , Sourav Halder , Xinyi Liu , Dustin A. Carlson , Peter J. Kahrilas , John E. Pandolfino , Neelesh A. Patankar

Neuromorphic engineering makes use of mixed-signal analog and digital circuits to directly emulate the computational principles of biological brains. Such electronic systems offer a high degree of adaptability, robustness, and energy…

Systems and Control · Electrical Eng. & Systems 2026-04-09 Loris Mendolia , Chenxi Wen , Elisabetta Chicca , Giacomo Indiveri , Rodolphe Sepulchre , Jean-Michel Redouté , Alessio Franci

Robots must satisfy safety-critical state and input constraints despite disturbances and model mismatch. We introduce a robust model predictive control (RMPC) formulation that is fast, scalable, and compatible with real-time implementation.…

Optimization and Control · Mathematics 2025-09-24 Antoine P. Leeman , Johannes Köhler , Melanie N. Zeilinger

The system of modular neural circuits that controls crustacean swimmerets drives a metachronal sequence of power-stroke and return-stroke movements that propels the animal forward efficiently. These neural modules are synchronized by an…

Neurons and Cognition · Quantitative Biology 2014-07-14 Brian Mulloney , Carmen Smarandache-Wellmann , Cynthia Weller , Wendy M. Hall , Ralph A. DiCaprio

This paper proposes a robust control design method using reinforcement-learning for controlling partially-unknown dynamical systems under uncertain conditions. The method extends the optimal reinforcement-learning algorithm with a new…

Systems and Control · Electrical Eng. & Systems 2020-04-17 Phuong D. Ngo , Fred Godtliebsen

Background. Organisms use a variety of mechanisms to protect themselves against perturbations. For example, repair mechanisms fix damage, feedback loops keep homeostatic systems at their setpoints, and biochemical filters distinguish signal…

Populations and Evolution · Quantitative Biology 2011-12-14 Steven A. Frank

Accurate motion control in the face of disturbances within complex environments remains a major challenge in robotics. Classical model-based approaches often struggle with nonlinearities and unstructured disturbances, while RL-based methods…

Robotics · Computer Science 2025-05-23 Feng Gao , Chao Yu , Yu Wang , Yi Wu

Cells and tissues exhibit oscillatory deformations during remodelling, migration or embryogenesis. Although it has been shown that these oscillations correlate with cell biochemical signalling, it is yet unclear the role of these…

Tissues and Organs · Quantitative Biology 2021-01-20 Malik A Dawi , Jose J Munoz

Understanding how the brain learns to compute functions reliably, efficiently and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could…

Neurons and Cognition · Quantitative Biology 2017-05-24 Sophie Denève , Alireza Alemi , Ralph Bourdoukan

We construct two error feedback controllers for robust output tracking and disturbance rejection of a regular linear system with nonsmooth reference and disturbance signals. We show that for sufficiently smooth signals the output converges…

Optimization and Control · Mathematics 2023-03-01 Lassi Paunonen

Deployment of robotic systems in the real world requires a certain level of robustness in order to deal with uncertainty factors, such as mismatches in the dynamics model, noise in sensor readings, and communication delays. Some approaches…

Robotics · Computer Science 2023-10-04 Henrique Ferrolho , Vladimir Ivan , Wolfgang Merkt , Ioannis Havoutis , Sethu Vijayakumar

Multistability, the coexistence of multiple attractors in a dynamical system, is explored in bursting nerve cells. A modeling study is performed to show that a large class of bursting systems, as defined by a shared topology when…

Neurons and Cognition · Quantitative Biology 2010-06-29 J. P. Newman , R. J. Butera

Robustness of spatial pattern against perturbations is an indispensable property of developmental processes for organisms, which need to adapt to changing environments. Although specific mechanisms for this robustness have been extensively…

Adaptation and Self-Organizing Systems · Physics 2017-04-05 Tetsuhiro S. Hatakeyama , Kunihiko Kaneko

The timing of human labor is among the most critical determinants of neonatal survival, yet the mechanisms that govern the transition from uterine quiescence to coordinated contractions remain elusive. Here we present a dynamical-systems…

Biological Physics · Physics 2026-01-13 Giuseppe Maria Ferro , Andrea Somazzi , Didier Sornette

The human brain is a complex dynamical system which displays a wide range of macroscopic and mesoscopic patterns of neural activity, whose mechanistic origin remains poorly understood. Whole-brain modelling allows us to explore candidate…

Neurons and Cognition · Quantitative Biology 2025-04-25 Cristiana Dimulescu , Ronja Strömsdörfer , Agnes Flöel , Klaus Obermayer

The robust disturbance rejection controller has been the subject of intensive research due to its undeniable importance for automation. Modern control theory tends to use model-based approaches versus model-free approaches, especially when…

Systems and Control · Electrical Eng. & Systems 2022-01-03 Atta Oveisi

As machine learning models become increasingly prevalent in critical decision-making models and systems in fields like finance, healthcare, etc., ensuring their robustness against adversarial attacks and changes in the input data is…

Machine Learning · Statistics 2024-08-05 Arun Prakash R , Anwesha Bhattacharyya , Joel Vaughan , Vijayan N. Nair

Much recent progress has been achieved for stabilization of linear and nonlinear systems with input delays that are long and dependent on either time or the plant state---provided the dependence is known. In this paper we consider the delay…

Optimization and Control · Mathematics 2012-09-11 Nikolaos Bekiaris-Liberis , Miroslav Krstic

Some biological systems operate at the critical point between stability and instability and this requires a fine-tuning of parameters. We bring together two examples from the literature that illustrate this: neural integration in the…

Optimization and Control · Mathematics 2007-05-23 Luc Moreau , Eduardo Sontag

This paper considers the robustness of an uncertain nonlinear system along a finite-horizon trajectory. The uncertain system is modeled as a connection of a nonlinear system and a perturbation. The analysis relies on three ingredients.…

Systems and Control · Electrical Eng. & Systems 2025-08-05 Peter Seiler , Raghu Venkataraman