Related papers: Chemical Case Studies in KeYmaera X
Robotic cell injection is used for automatically delivering substances into a cell and is an integral component of drug development, genetic engineering and many other areas of cell biology. Traditionally, the correctness of functionality…
Technology advances give us the hope of driving without human error, reducing vehicle emissions and simplifying an everyday task with the future of self-driving cars. Making sure these vehicles are safe is very important to the continuation…
This paper describes a method for creating compelling safety cases. The method seeks to help improve safety case practice in order to address the weaknesses identified in current practice, in particular confirmation bias, after-the-fact…
We present an adjoint sensitivity method for hybrid discrete -- continuous systems, extending previously published forward sensitivity methods. We treat ordinary differential equations and differential-algebraic equations of index up to two…
Polynomial dynamical systems are widely used to model and study real phenomena. In biochemistry, they are the preferred choice for modelling the concentration of chemical species in reaction networks with mass-action kinetics. These systems…
Programmable Logic Controllers (PLCs) provide a prominent choice of implementation platform for safety-critical industrial control systems. Formal verification provides ways of establishing correctness guarantees, which can be quite…
We combine quantified differential dynamic logic (QdL) for reasoning about the possible behavior of distributed hybrid systems with temporal logic for reasoning about the temporal behavior during their operation. Our logic supports…
For the design and implementation of engineering systems, performing model-based analysis can disclose potential safety issues at an early stage. The analysis of hybrid system models is in general difficult due to the intrinsic complexity…
Computer-Controlled Systems (CCS) are a subclass of hybrid systems where the periodic relation of control components to time is paramount. Since they additionally are at the heart of many safety-critical devices, it is of primary importance…
An important tool for proving safety of dynamical systems is the notion of a barrier certificate. In this paper we prove that every robustly safe ordinary differential equation has a barrier certificate. Moreover, we show a construction of…
The safety of automated driving systems must be justified by convincing arguments and supported by compelling evidence to persuade certification agencies, regulatory entities, and the general public to allow the systems on public roads.…
This paper introduces operators, semantics, characterizations, and solution-independent conditions to guarantee temporal logic specifications for hybrid dynamical systems. Hybrid dynamical systems are given in terms of differential…
Mathematical models are crucial for optimizing and controlling chemical processes, yet they often face significant limitations in terms of computational time, algorithm complexity, and development costs. Hybrid models, which combine…
Piecewise smooth hybrid systems, involving continuous and discrete variables, are suitable models for describing the multiscale regulatory machinery of the biological cells. In hybrid models, the discrete variables can switch on and off…
This paper establishes a general framework for describing hybrid dynamical systems which is particularly suitable for numerical simulation. In this context, the data structures used to describe the sets and functions which comprise the…
The increasing integration of renewable energy sources has introduced complex dynamic behavior in power systems that challenge the adequacy of traditional continuous-time modeling approaches. These developments call for modeling frameworks…
The three-dimensional XY model is studied at finite chemical potential using complex Langevin dynamics. An adaptive stepsize algorithm is implemented to cure the problem of runaway solutions that appears when using a constant stepsize. The…
The most important factor for quantitative results in molecular dynamics simulation are well developed force fields and models. In the present work, the development of new models and the usage of force fields from the literature in large…
We demonstrate the possibility of classifying causal systems into kinds that share a common structure without first constructing an explicit dynamical model or using prior knowledge of the system dynamics. The algorithmic ability to…
Context: Safety is of paramount importance for cyber-physical systems in domains such as automotive, robotics, and avionics. Formal methods such as model checking are one way to ensure the safety of cyber-physical systems. However, adoption…