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We study extensions of the classical SIR model of epidemic spread. First, we consider a single population modified SIR epidemics model in which the contact rate is allowed to be an arbitrary function of the fraction of susceptible and…

Dynamical Systems · Mathematics 2021-12-17 Martina Alutto , Giacomo Como , Fabio Fagnani

Aging research has produced powerful explanatory frameworks -- evolutionary theories, the Hallmarks of Aging, SENS, geroscience, hyperfunction, and information-loss models -- yet none provides quantitative rules for determining which…

Molecular Networks · Quantitative Biology 2026-05-19 Alex Zhavoronkov

We propose a network behavioral-feedback Susceptible-Infected-Recovered (SIR) epidemic model in which the interaction matrix describing the infection rates across subpopulations depends in feedback on the current epidemic state. This model…

Dynamical Systems · Mathematics 2025-07-08 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani

When an infectious disease propagates throughout society, the incidence function may rise at first due to an increase in pathogenicity and then decrease due to inhibitory effects until it reaches saturation. Effective vaccination and…

Dynamical Systems · Mathematics 2023-07-11 Sushil Pathak , G. Shirisha , K. Venkata Ratnam

We consider an epidemiological model that includes waning and boosting of immunity. Assuming that repeated exposure to the pathogen fully restores immunity, we derive an SIRS-type model with discrete and distributed delays. First we prove…

Dynamical Systems · Mathematics 2016-06-14 Maria Vittoria Barbarossa , Monika Polner , Gergely Röst

We are interested in the control of forming processes for nonlinear material models. To develop an online control we derive a novel feedback law and prove a stabilization result. The derivation of the feedback control law is based on a…

Optimization and Control · Mathematics 2021-04-13 Markus Bambach , Michael Herty , Muhammad Imran

A supervised learning approach for the solution of large-scale nonlinear stabilization problems is presented. A stabilizing feedback law is trained from a dataset generated from State-dependent Riccati Equation solves. The training phase is…

Optimization and Control · Mathematics 2021-03-09 Giacomo Albi , Sara Bicego , Dante Kalise

In this paper, we study the positivity and (uniform) exponential stability of a large class of perturbed semigroups. Our approach is essentially based on the feedback theory of infinite-dimensional linear systems. The obtained results are…

Functional Analysis · Mathematics 2021-03-31 Abed Boulouz , Hamid Bounit , Said Hadd

The principle of linearized stability is established for age-structured diffusive populations incorporating nonlinear death and birth processes. More precisely, asymptotic exponential stability is shown for equilibria for which the…

Analysis of PDEs · Mathematics 2022-01-03 Christoph Walker , Josef Zehetbauer

We study the dynamics of a SIR epidemic model with nonlinear incidence rate, vertical transmission vaccination for the newborns and the capacity of treatment, that takes into account the limitedness of the medical resources and the…

Dynamical Systems · Mathematics 2015-01-27 Erika Rivero-Esquivel , Eric Ávila-Vales , Gerardo E. García-Almeida

Social distancing has been enacted in order to mitigate the spread of COVID-19. Like many authors, we adopt the classic epidemic SIR model, where the infection rate is the control variable. Its differential flatness property yields ele…

Systems and Control · Electrical Eng. & Systems 2022-10-05 Michel Fliess , Cédric Join , Alberto d'Onofrio

Symmetries of nonlinear control systems in state representation are considered. To this end, a geometric approach to ordinary differential equations is advocated. Invariant feedback laws for systems with Lie symmetries, i.e. feedback laws…

Optimization and Control · Mathematics 2012-06-22 Carsten Collon , Joachim Rudolph

We consider a class of physiologically structured population models, a first order nonlinear partial differential equation equipped with a nonlocal boundary condition, with a constant external inflow of individuals. We prove that the…

Analysis of PDEs · Mathematics 2019-03-25 Jozsef Z. Farkas

This paper studies an optimal control problem for a class of SIR epidemic models, in scenarios in which the infected population is constrained to be lower than a critical threshold imposed by the ICU (intensive care unit) capacity. The…

Optimization and Control · Mathematics 2024-12-31 Matteo Della Rossa , Lorenzo Freddi , Dan Goreac

This paper focuses on the problem of constructing time-varying feedback laws that asymptotically stabilize a given part of the state variables for nonlinear control-affine systems. It is assumed that the class of systems under consideration…

Optimization and Control · Mathematics 2021-05-21 Victoria Grushkovskaya , Alexander Zuyev

This paper deals with an SIR model with saturated incidence rate affected by inhibitory effect and saturated treatment function. Two control functions have been used, one for vaccinating the susceptible population and other for the…

Dynamical Systems · Mathematics 2018-07-17 Jayanta Kumar Ghosh , Uttam Ghosh , M. H. A. Biswas , Susmita Sarkar

This paper utilizes a stochastic Susceptible-Infected-recovered (SIR) model with a non-linear incidence rate to perform a detailed mathematical study of optimal lock-down intensity and vaccination rate under the COVID-19 pandemic…

Optimization and Control · Mathematics 2022-09-29 Paramahansa Pramanik

We consider a SIR model with temporary immunity and time dependent transmission rate. We assume time dependent vaccination which confers the same immunity as natural infection. We study two types of vaccination strategies: i) optimal…

Populations and Evolution · Quantitative Biology 2016-04-06 Paulo Doutor , Paula Rodrigues , Maria do Céu Soares , Fabio A. C. C. Chalub

Vaccination campaigns have both direct and indirect effects that act to control an infectious disease as it spreads through a population. Indirect effects arise when vaccinated individuals block disease transmission in any infection chains…

Populations and Evolution · Quantitative Biology 2024-05-08 Lixin Lin , Homayoun Hamedmoghadam , Robert Shorten , Lewi Stone

We analyze an optimal control version of a simple SIRS epidemiology model. The policy maker can adopt policies to diminish the contact rate between infected and susceptible individuals, at a specific economic cost. The arrival of a vaccine…

Populations and Evolution · Quantitative Biology 2020-06-09 Evangelos Magirou