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In this paper we establish a connection between non-convex optimization methods for training deep neural networks and nonlinear partial differential equations (PDEs). Relaxation techniques arising in statistical physics which have already…

Machine Learning · Computer Science 2017-06-05 Pratik Chaudhari , Adam Oberman , Stanley Osher , Stefano Soatto , Guillaume Carlier

Estimating the unconstrained mean and covariance matrix is a popular topic in statistics. However, estimation of the parameters of $N_p(\mu,\Sigma)$ under joint constraints such as $\Sigma\mu = \mu$ has not received much attention. It can…

Methodology · Statistics 2023-01-25 Anupam Kundu , Mohsen Pourahmadi

High-dimensional data pose challenges in statistical learning and modeling. Sometimes the predictors can be naturally grouped where pursuing the between-group sparsity is desired. Collinearity may occur in real-world high-dimensional…

Machine Learning · Statistics 2011-11-11 Yiyuan She

Optimization problems with norm-bounding constraints arise in a variety of applications, including portfolio optimization, machine learning, and feature selection. A common approach to these problems involves relaxing the norm constraint…

Optimization and Control · Mathematics 2025-05-08 Danial Davarnia , Mohammadreza Kiaghadi

For many algorithms, parameter tuning remains a challenging and critical task, which becomes tedious and infeasible in a multi-parameter setting. Multi-penalty regularization, successfully used for solving undetermined sparse regression of…

Machine Learning · Statistics 2017-10-12 Markus Grasmair , Timo Klock , Valeriya Naumova

In recent years, bilevel approaches have become very popular to efficiently estimate high-dimensional hyperparameters of machine learning models. However, to date, binary parameters are handled by continuous relaxation and rounding…

Machine Learning · Computer Science 2025-03-20 Sara Venturini , Marianna de Santis , Jordan Patracone , Francesco Rinaldi , Saverio Salzo , Martin Schmidt

This paper studies $\ell_1$ regularization with high-dimensional features for support vector machines with a built-in reject option (meaning that the decision of classifying an observation can be withheld at a cost lower than that of…

Statistics Theory · Mathematics 2012-01-06 Marten Wegkamp , Ming Yuan

Longitudinal data analysis is fundamental for understanding dynamic processes in biomedical and social sciences. Although varying coefficient models (VCMs) provide a flexible framework by allowing covariate effects to evolve over time,…

Methodology · Statistics 2026-03-10 Yu Lu , Tianni Zhang , Yuyao Wang , Mengfei Ran

Temporal expression (TE) normalization is a well-studied problem. However, the predominately used rule-based systems are highly restricted to specific settings, and upcoming machine learning approaches suffer from a lack of labeled data. In…

Computation and Language · Computer Science 2024-04-12 Akash Kumar Gautam , Lukas Lange , Jannik Strötgen

We present new policy mirror descent (PMD) methods for solving reinforcement learning (RL) problems with either strongly convex or general convex regularizers. By exploring the structural properties of these overall highly nonconvex…

Machine Learning · Computer Science 2022-04-08 Guanghui Lan

One of the key technologies for the success of Large Language Models (LLMs) is preference alignment. However, a notable side effect of preference alignment is poor calibration: while the pre-trained models are typically well-calibrated,…

Machine Learning · Computer Science 2025-10-17 Jiancong Xiao , Bojian Hou , Zhanliang Wang , Ruochen Jin , Qi Long , Weijie J. Su , Li Shen

In multi-state models based on high-dimensional data, effective modeling strategies are required to determine an optimal, ideally parsimonious model. In particular, linking covariate effects across transitions is needed to conduct joint…

Methodology · Statistics 2024-11-27 Kaya Miah , Jelle J. Goeman , Hein Putter , Annette Kopp-Schneider , Axel Benner

Penalized estimation can conduct variable selection and parameter estimation simultaneously. The general framework is to minimize a loss function subject to a penalty designed to generate sparse variable selection. The…

Computation · Statistics 2024-01-11 Zhu Wang

Latent variable models are a fundamental modeling tool in machine learning applications, but they present significant computational and analytical challenges. The popular EM algorithm and its variants, is a much used algorithmic tool; yet…

Machine Learning · Computer Science 2015-12-08 Xinyang Yi , Constantine Caramanis

Multivariate Analysis (MVA) comprises a family of well-known methods for feature extraction which exploit correlations among input variables representing the data. One important property that is enjoyed by most such methods is uncorrelation…

Machine Learning · Computer Science 2021-12-24 Sergio Muñoz-Romero , Vanessa Gómez-Verdejo , Jerónimo Arenas-García

Benkeser et al. demonstrate how adjustment for baseline covariates in randomized trials can meaningfully improve precision for a variety of outcome types. Their findings build on a long history, starting in 1932 with R.A. Fisher and…

Methodology · Statistics 2026-03-03 Laura B. Balzer , Erica Cai , Lucas Godoy Garraza , Pracheta Amaranath

Latent Variable Models (LVMs) are a large family of machine learning models providing a principled and effective way to extract underlying patterns, structure and knowledge from observed data. Due to the dramatic growth of volume and…

Machine Learning · Computer Science 2015-12-24 Pengtao Xie , Yuntian Deng , Eric Xing

BACKGROUND: Random-effects meta-analysis within a hierarchical normal modeling framework is commonly implemented in a wide range of evidence synthesis applications. More general problems may even be tackled when considering meta-regression…

Computation · Statistics 2022-12-27 Christian Röver , Tim Friede

Markov-switching models are powerful tools that allow capturing complex patterns from time series data driven by latent states. Recent work has highlighted the benefits of estimating components of these models nonparametrically, enhancing…

Methodology · Statistics 2024-11-19 Jan-Ole Koslik

In this work we are interested in the problems of supervised learning and variable selection when the input-output dependence is described by a nonlinear function depending on a few variables. Our goal is to consider a sparse nonparametric…

Machine Learning · Statistics 2012-08-14 Lorenzo Rosasco , Silvia Villa , Sofia Mosci , Matteo Santoro , Alessandro verri