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Since the coronavirus disease (COVID-19) outbreak in December 2019, studies have been addressing diverse aspects in relation to COVID-19 and Variant of Concern 202012/01 (VOC 202012/01) such as potential symptoms and predictive tools.…

Machine Learning · Computer Science 2021-02-02 Wasiq Khan , Abir Hussain , Sohail Ahmed Khan , Mohammed Al-Jumailey , Raheel Nawaz , Panos Liatsis

In individual SARS-CoV-2 outbreaks, the count of confirmed cases and deaths follow a Gompertz growth function for locations of very different sizes. This lack of dependence on region size leads us to hypothesize that virus spread depends on…

Populations and Evolution · Quantitative Biology 2022-01-03 Francesco Zonta , Andrea Scaiewicz , Michael Levitt

[Abridged] Naturally produced droplets from humans (such as those produced by breathing, talking, sneezing, and coughing) include several types of cells (e.g., epithelial cells and cells of the immune system), physiological electrolytes…

Popular Physics · Physics 2020-09-01 Luis A. Anchordoqui , Eugene M. Chudnovsky

Proteins play a key role in facilitating the infectiousness of the 2019 novel coronavirus. A specific spike protein enables this virus to bind to human cells, and a thorough understanding of its 3-dimensional structure is therefore critical…

Biomolecules · Quantitative Biology 2020-10-28 Samuel W. K. Wong

Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. It was first identified in Wuhan, China, and has since spread causing a global pandemic. Various studies have been performed to understand the…

The recent global surge in COVID-19 infections has been fueled by new SARS-CoV-2 variants, namely Alpha, Beta, Gamma, Delta, etc. The molecular mechanism underlying such surge is elusive due to 4,653 non-degenerate mutations on the spike…

Biomolecules · Quantitative Biology 2021-09-13 Rui Wang , Jiahui Chen , Yuta Hozumi , Changchuan Yin , Guo-Wei Wei

Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature…

Populations and Evolution · Quantitative Biology 2020-11-20 Jacopo Marchi , Michael Lässig , Thierry Mora , Aleksandra M. Walczak

In late 2019, COVID-19, a severe respiratory disease, emerged, and since then, the world has been facing a deadly pandemic caused by it. This ongoing pandemic has had a significant effect on different aspects of societies. The uncertainty…

Neural and Evolutionary Computing · Computer Science 2021-09-28 Mahdi Rahbar , Samaneh Yazdani

Since late 2019 the novel coronavirus, also known as COVID-19, has caused a pandemic that persists. This paper shows how a continuous-time Markov chain model for the spread of COVID-19 can be used to explain, and justify to undergraduate…

Applications · Statistics 2022-06-22 Armine Bagyan , Donald Richards

With the unprecedented global vaccination campaign against SARS-CoV-2 attention has now turned to the potential impact of this large-scale intervention on the evolution of the virus. In this perspective we summarize what is currently known…

Populations and Evolution · Quantitative Biology 2022-02-01 Troy Day , David A. Kennedy , Andrew F. Read , Sylvain Gandon

Although traditional models of epidemic spreading focus on the number of infected, susceptible and recovered individuals, a lot of attention has been devoted to integrate epidemic models with population genetics. Here we develop an…

Populations and Evolution · Quantitative Biology 2021-11-24 Vitor M. Marquioni , Marcus A. M. de Aguiar

The dynamics of epidemics depend on how people's behavior changes during an outbreak. At the beginning of the epidemic, people do not know about the virus, then, after the outbreak of epidemics and alarm, they begin to comply with the…

Physics and Society · Physics 2021-11-29 I. A. Kastalskiy , E. V. Pankratova , E. M. Mirkes , V. B. Kazantsev , A. N. Gorban

Forecasting the change in the distribution of viral variants is crucial for therapeutic design and disease surveillance. This task poses significant modeling challenges due to the sharp differences in virus distributions across…

Machine Learning · Computer Science 2025-04-24 Wenxian Shi , Menghua Wu , Regina Barzilay

The SARS-CoV-2 coronavirus, the etiologic agent responsible for COVID-19 coronavirus disease, is a global threat. To better understand viral tropism, we assessed the RNA expression of the coronavirus receptor, ACE2, as well as the viral S…

Cell Behavior · Quantitative Biology 2020-04-27 Waradon Sungnak , Ni Huang , Christophe Bécavin , Marijn Berg , HCA Lung Biological Network

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth…

The outbreak of COVID-19 i.e. a variation of coronavirus, also known as novel corona virus causing respiratory disease is a big concern worldwide since the end of December 2019. As of September 12, 2020, it has turned into an epidemic…

Machine Learning · Computer Science 2020-10-08 Neeraj , Jimson Mathew , Ranjan Kumar Behera , Zenin Easa Panthakkalakath

The recent outbreak of a novel coronavirus (2019-nCoV) has quickly evolved into a global health crisis. The transmission potential of 2019-nCoV has been modelled and studied in several recent research works. The key factors such as the…

Populations and Evolution · Quantitative Biology 2020-02-11 Jun Li

Very recently the new pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified and the coronavirus disease 2019 (COVID-19) declared a pandemic by the World Health Organization. The pandemic has a number of…

We comparatively analyzed the spatiotemporal fluctuations of the 2019-novel coronavirus (COVID-19) and SARS outbreaks to understand their epidemiological characteristics. Methodologically, we introduced TPL (Taylor power law) to…

Populations and Evolution · Quantitative Biology 2020-03-10 Zhanshan Ma

The clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the strain of coronavirus that caused the COVID-19 pandemic, is broad, extending from asymptomatic infection to severe immunopulmonary reactions that, if…

Quantitative Methods · Quantitative Biology 2022-07-18 Aaron Wang , Feng Li , Samantha Chiang , Jennifer Fulcher , Otto Yang , David Wong , Fang Wei
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