Related papers: Neuronal Growth and Formation of Neuron Networks o…
Axonal growth and the formation of synaptic connections are key steps in the development of the nervous system. Here we present experimental and theoretical results on axonal growth and interconnectivity in order to elucidate some of the…
A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system. The interstitial branching along primary axon shaft occurs during nervous…
Geometrical cues are known to play a very important role in neuronal growth and the formation of neuronal networks. Here, we present a detailed analysis of axonal growth and dynamics for neuronal cells cultured on patterned…
Neuronal circuits arise as axons and dendrites extend, navigate, and connect to target cells. Axonal growth, in particular, integrates deterministic guidance from substrate mechanics and geometry with stochastic fluctuations generated by…
Neuronal networks constitute a special class of dynamical systems, as they are formed by individual geometrical components, namely the neurons. In the existing literature, relatively little attention has been given to the influence of…
During neurodevelopment, neuronal axons navigate through the extracellular environment, guided by various cues to establish connections with distant target cells. Among other factors, axon trajectories are influenced by heterogeneities in…
Despite significant advances in understanding neuronal development, a fully quantitative framework that integrates intracellular mechanisms with environmental cues during axonal growth remains incomplete. Here, we present a unified…
Geometrical cues play an essential role in neuronal growth. Here, we quantify axonal growth on surfaces with controlled geometries and report a general stochastic approach that quantitatively describes the motion of growth cones. We show…
Axon guidance (AG) towards their target during embryogenesis or after injury is an important issue in the development of neuronal networks. During their growth, axons often face complex decisions that are difficult to understand when…
It is currently accepted that cortical maps are dynamic constructions that are altered in response to external input. Experience-dependent structural changes in cortical microcurcuts lead to changes of activity, i.e. to changes in…
Neural development represents not only an exciting and complex field of study, with ongoing progress, but it also became the epicentre of neuroscience and developmental biology, as it strives to describe the underlying cellular and…
Early brain connectivity development consists of multiple stages: birth of neurons, their migration and the subsequent growth of axons and dendrites. Each stage occurs within a certain period of time depending on types of neurons and…
In biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network. Despite this…
Current understanding of neuronal growth is mostly qualitative, as the staggering number of physical and chemical guidance cues involved prohibit a fully quantitative description of axonal dynamics. We report on a general approach that…
In contrast to conventional artificial neural networks, which are structurally static, we present two approaches for evolving small networks into larger ones during training. The first method employs an auxiliary weight that directly…
The quintessential property of neuronal systems is their intensive patterns of selective synaptic connections. The current work describes a physics-based approach to neuronal shape modeling and synthesis and its consideration for the…
The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection away from a neuron. Under normal conditions two axonal cytoskeletal polymers microtubules and neurofilaments…
Thin film coatings have been essential in development of several micro and nano-scale devices. To realize thin film coatings various deposition techniques are employed, each yielding surface morphologies with different characteristics of…
Vascular networks play a key role in the development, function, and survival of many organisms, facilitating transport of nutrients and other critical factors within and between systems. The development of these vessel networks has been…
A fundamental task in developmental biology is to identify the mechanisms which drive morphogenesis. In many cases, pattern formation is driven by the positional information determined by both the gradient of maternal factors and hard-wired…