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In the past several years, the problem of genome assembly has received considerable attention from both biologists and computer scientists. An important component of current assembly methods is the scaffolding process. This process involves…

Genomics · Quantitative Biology 2013-07-03 Karl R. B. Schmitt , Aleksey V. Zimin , Guillaume Marcaçs , James A. Yorke , Michelle Girvan

Proof terms are syntactic expressions that represent computations in term rewriting. They were introduced by Meseguer and exploited by van Oostrom and de Vrijer to study equivalence of reductions in (left-linear) first-order term rewriting…

Symbolic Computation · Computer Science 2023-08-17 Pablo Barenbaum , Eduardo Bonelli

We propose a framework for solving evolution equations within parametric function classes, especially ones that are specified by neural networks. We call this framework the minimal neural evolution (MNE) because it is motivated by the goal…

Numerical Analysis · Mathematics 2025-02-07 Michael Lindsey

Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from revealing the proteins' common origin. Moreover, when a large number of…

Quantitative Methods · Quantitative Biology 2011-01-18 Marta L. Gîrdea , Laurent Noé , Gregory Kucherov

We propose masked particle modeling (MPM) as a self-supervised method for learning generic, transferable, and reusable representations on unordered sets of inputs for use in high energy physics (HEP) scientific data. This work provides a…

High Energy Physics - Phenomenology · Physics 2024-07-12 Tobias Golling , Lukas Heinrich , Michael Kagan , Samuel Klein , Matthew Leigh , Margarita Osadchy , John Andrew Raine

This work aims to study and explore the use of Gene Expression Programming (GEP) in solving the on-line Bin-Packing problem. The main idea is to show how GEP can automatically find acceptable heuristic rules to solve the problem efficiently…

Neural and Evolutionary Computing · Computer Science 2020-01-28 Najla Akram Al-Saati

We investigate the symmetry of circular genome rearrangement models, discuss the implementation of a new representation-theoretic method of calculating evolutionary distances between circular genomes, and give the results of some initial…

Populations and Evolution · Quantitative Biology 2017-12-05 Venta Terauds , Jeremy Sumner

De novo genome assembly focuses on finding connections between a vast amount of short sequences in order to reconstruct the original genome. The central problem of genome assembly could be described as finding a Hamiltonian path through a…

Machine Learning · Computer Science 2020-11-11 Lovro Vrček , Petar Veličković , Mile Šikić

We present ensemble methods in a machine learning (ML) framework combining predictions from five known motif/binding site exploration algorithms. For a given TF the ensemble starts with position weight matrices (PWM's) for the motif,…

Genomics · Quantitative Biology 2018-05-11 Yue Fan , Mark Kon , Charles DeLisi

Here we propose an evolutionary algorithm that self modifies its operators at the same time that candidate solutions are evolved. This tackles convergence and lack of diversity issues, leading to better solutions. Operators are represented…

Neural and Evolutionary Computing · Computer Science 2017-12-19 Andres Felipe Cruz Salinas , Jonatan Gomez Perdomo

The study of the fundamental limits of information systems is a central theme in information theory. Both the traditional analytical approach and the recently proposed computational approach have significant limitations, where the former is…

Information Theory · Computer Science 2022-05-04 Wenjing Chen , Chao Tian

In order to survive, reproduce and (in multicellular organisms) differentiate, cells must control the concentrations of the myriad different proteins that are encoded in the genome. The precision of this control is limited by the inevitable…

Molecular Networks · Quantitative Biology 2013-08-01 Gasper Tkacik , Aleksandra M. Walczak , William Bialek

Sorting is one of the most used and well investigated algorithmic problem [1]. Traditional postulation supposes the sorting data archived, and the elementary operation as comparisons of two numbers. In a view of appearance of new processors…

Data Structures and Algorithms · Computer Science 2011-07-22 Hakob Aslanyan

How robust is the natural genetic code with respect to mistranslation errors? It has long been known that the genetic code is very efficient in limiting the effect of point mutation. A misread codon will commonly code either for the same…

Biological Physics · Physics 2009-11-03 Dimitri Gilis , Serge Massar , Nicolas Cerf , Marianne Rooman

In a model of network communication based on a random walk in an undirected graph, what subset of nodes (subject to constraints on the set size), enable the fastest spread of information? The dynamics of spread is described by a process…

Discrete Mathematics · Computer Science 2016-02-23 Fern Y. Hunt

The Progressive Edge Growth (PEG) algorithm is one of the most widely-used method for constructing finite length LDPC codes. In this paper we consider the PEG algorithm together with a scheduling distribution, which specifies the order in…

Information Theory · Computer Science 2011-03-15 Lam Pham Sy , Valentin Savin , David Declercq , Nghia Pham

Programmable arrays of optical traps enable the assembly of configurations of single atoms to perform controlled experiments on quantum many-body systems. Finding the sequence of control operations to transform an arbitrary configuration of…

In this paper, we present an algorithm that enumerates a certain class of signed permutations, referred to as grid signed permutation classes. In the case of permutations, the corresponding grid classes are of interest because they are…

Combinatorics · Mathematics 2023-06-02 Saúl A. Blanco , Daniel E. Skora

Phylogenetic networks are increasingly used in evolutionary biology to represent the history of species that have undergone reticulate events such as horizontal gene transfer, hybrid speciation and recombination. One of the most fundamental…

Populations and Evolution · Quantitative Biology 2016-10-07 Philippe Gambette , Leo van Iersel , Steven Kelk , Fabio Pardi , Celine Scornavacca

Prolog's ability to return multiple answers on backtracking provides an elegant mechanism to derive reversible encodings of combinatorial objects as Natural Numbers i.e. {\em ranking} and {\em unranking} functions. Starting from a…

Logic in Computer Science · Computer Science 2008-08-06 Paul Tarau