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Machine learning methods applied to complex biomedical data has enabled the construction of disease signatures of diagnostic/prognostic value. However, less attention has been given to understanding disease heterogeneity. Semi-supervised…

Quantitative Methods · Quantitative Biology 2020-06-30 Zhijian Yang , Junhao Wen , Christos Davatzikos

Heterogeneity of brain diseases is a challenge for precision diagnosis/prognosis. We describe and validate Smile-GAN (SeMI-supervised cLustEring-Generative Adversarial Network), a novel semi-supervised deep-clustering method, which dissects…

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially…

Magnetic Resonance Imaging (MRI) of the brain can come in the form of different modalities such as T1-weighted and Fluid Attenuated Inversion Recovery (FLAIR) which has been used to investigate a wide range of neurological disorders.…

Machine Learning · Computer Science 2019-12-11 Harrison Nguyen , Simon Luo , Fabio Ramos

Medical anomaly detection is a critical research area aimed at recognizing abnormal images to aid in diagnosis.Most existing methods adopt synthetic anomalies and image restoration on normal samples to detect anomaly. The unlabeled data…

Image and Video Processing · Electrical Eng. & Systems 2024-05-22 Zerui Zhang , Zhichao Sun , Zelong Liu , Bo Du , Rui Yu , Zhou Zhao , Yongchao Xu

Recently deep learning methods, in particular, convolutional neural networks (CNNs), have led to a massive breakthrough in the range of computer vision. Also, the large-scale annotated dataset is the essential key to a successful training…

Image and Video Processing · Electrical Eng. & Systems 2020-11-17 Chang Qi , Junyang Chen , Guizhi Xu , Zhenghua Xu , Thomas Lukasiewicz , Yang Liu

Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical image to detect outliers either in…

Computer Vision and Pattern Recognition · Computer Science 2020-10-13 Changhee Han , Leonardo Rundo , Kohei Murao , Tomoyuki Noguchi , Yuki Shimahara , Zoltan Adam Milacski , Saori Koshino , Evis Sala , Hideki Nakayama , Shinichi Satoh

Supervised deep learning algorithms have enabled significant performance gains in medical image classification tasks. But these methods rely on large labeled datasets that require resource-intensive expert annotation. Semi-supervised…

Convolutional Neural Networks (CNNs) can play a key role in Medical Image Analysis under large-scale annotated datasets. However, preparing such massive dataset is demanding. In this context, Generative Adversarial Networks (GANs) can…

Image and Video Processing · Electrical Eng. & Systems 2021-06-04 Changhee Han

Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…

Machine Learning · Computer Science 2026-03-23 Alireza Moayedikia , Sara Fin

In recent years, there are many research cases for the diagnosis of Parkinson's disease (PD) with the brain magnetic resonance imaging (MRI) by utilizing the traditional unsupervised machine learning methods and the supervised deep learning…

Image and Video Processing · Electrical Eng. & Systems 2020-03-11 Xiaobo Zhang , Donghai Zhai , Yan Yang , Yiling Zhang , Chunlin Wang

The success of deep learning for medical imaging tasks, such as classification, is heavily reliant on the availability of large-scale datasets. However, acquiring datasets with large quantities of labeled data is challenging, as labeling is…

Image and Video Processing · Electrical Eng. & Systems 2021-09-29 Shafin Haque , Ayaan Haque

There is a growing amount of clinical, anatomical and functional evidence for the heterogeneous presentation of neuropsychiatric and neurodegenerative diseases such as schizophrenia and Alzheimers Disease (AD). Elucidating distinct subtypes…

Machine Learning · Computer Science 2020-07-13 Junhao Wen , Erdem Varol , Ganesh Chand , Aristeidis Sotiras , Christos Davatzikos

Unsupervised learning can discover various unseen diseases, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a single medical image to detect outliers either in the…

Image and Video Processing · Electrical Eng. & Systems 2020-03-18 Changhee Han , Leonardo Rundo , Kohei Murao , Zoltán Ádám Milacski , Kazuki Umemoto , Evis Sala , Hideki Nakayama , Shin'ichi Satoh

Image recognition is an important topic in computer vision and image processing, and has been mainly addressed by supervised deep learning methods, which need a large set of labeled images to achieve promising performance. However, in most…

Computer Vision and Pattern Recognition · Computer Science 2019-08-13 Haoqian Wang , Zhiwei Xu , Jun Xu , Wangpeng An , Lei Zhang , Qionghai Dai

The diagnosis of early stages of Alzheimer's disease (AD) is essential for timely treatment to slow further deterioration. Visualizing the morphological features for the early stages of AD is of great clinical value. In this work, a novel…

Image and Video Processing · Electrical Eng. & Systems 2021-11-29 Wen Yu , Baiying Lei , Yanyan Shen , Shuqiang Wang , Yong Liu , Zhiguang Feng , Yong Hu , Michael K. Ng

The imaging community has increasingly adopted machine learning (ML) methods to provide individualized imaging signatures related to disease diagnosis, prognosis, and response to treatment. Clinical neuroscience and cancer imaging have been…

Acquisition of data in task-specific applications of machine learning like plant disease recognition is a costly endeavor owing to the requirements of professional human diligence and time constraints. In this paper, we present a simple…

Computer Vision and Pattern Recognition · Computer Science 2019-09-27 Haseeb Nazki , Sook Yoon , Alvaro Fuentes , Dong Sun Park

Medical imaging datasets are inherently high dimensional with large variability and low sample sizes that limit the effectiveness of deep learning algorithms. Recently, generative adversarial networks (GANs) with the ability to synthesize…

Image and Video Processing · Electrical Eng. & Systems 2024-12-13 Apoorva Sikka , Skand Peri , Jitender Singh Virk , Usma Niyaz , Deepti R. Bathula

The identification of lesion within medical image data is necessary for diagnosis, treatment and prognosis. Segmentation and classification approaches are mainly based on supervised learning with well-paired image-level or voxel-level…

Computer Vision and Pattern Recognition · Computer Science 2019-04-09 Liyan Sun , Jiexiang Wang , Yue Huang , Xinghao Ding , Hayit Greenspan , John Paisley
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