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Generative modeling is typically framed as learning mapping rules, but from an observer's perspective without access to these rules, the task becomes disentangling the geometric support from the probability distribution. We propose that…

Machine Learning · Statistics 2025-12-04 Rui Tong

Likelihood-based, or explicit, deep generative models use neural networks to construct flexible high-dimensional densities. This formulation directly contradicts the manifold hypothesis, which states that observed data lies on a…

Machine Learning · Statistics 2022-11-30 Gabriel Loaiza-Ganem , Brendan Leigh Ross , Jesse C. Cresswell , Anthony L. Caterini

Generalized Category Discovery (GCD) aims to identify both known and unknown categories, with only partial labels given for the known categories, posing a challenging open-set recognition problem. State-of-the-art approaches for GCD task…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Wei He , Xianghan Meng , Zhiyuan Huang , Xianbiao Qi , Rong Xiao , Chun-Guang Li

Variational inference (VI) and Markov chain Monte Carlo (MCMC) are two main approximate approaches for learning deep generative models by maximizing marginal likelihood. In this paper, we propose using annealed importance sampling for…

Machine Learning · Statistics 2023-01-18 Xinqiang Ding , David J. Freedman

This article presents a novel method to sampling on manifolds based on the Dirichlet distribution. The proposed strategy allows to completely respect the underlying manifold around which data is observed, and to do massive samplings with…

Machine Learning · Statistics 2021-08-13 Luan S Prado , Thiago G Ritto

In the manifold learning problem one seeks to discover a smooth low dimensional surface, i.e., a manifold embedded in a higher dimensional linear vector space, based on a set of measured sample points on the surface. In this paper we…

Computer Vision and Pattern Recognition · Computer Science 2007-05-23 Jose Costa , Alfred Hero

Genetic Programming (GP) is an evolutionary algorithm commonly used for machine learning tasks. In this paper we present a method that allows GP to transform the representation of a large-scale machine learning dataset into a more compact…

Neural and Evolutionary Computing · Computer Science 2018-02-21 Lino Rodriguez-Coayahuitl , Alicia Morales-Reyes , Hugo Jair Escalante

Deep learning models such as convolutional neural net- work have been widely used in 3D biomedical segmentation and achieve state-of-the-art performance. However, most of them often adapt a single modality or stack multiple modalities as…

Computer Vision and Pattern Recognition · Computer Science 2017-04-26 Kuan-Lun Tseng , Yen-Liang Lin , Winston Hsu , Chung-Yang Huang

We propose a discrete latent distribution for Generative Adversarial Networks (GANs). Instead of drawing latent vectors from a continuous prior, we sample from a finite set of learnable latents. However, a direct parametrization of such a…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 Evangelos Ntavelis , Mohamad Shahbazi , Iason Kastanis , Radu Timofte , Martin Danelljan , Luc Van Gool

Machine Learning-guided solutions for protein learning tasks have made significant headway in recent years. However, success in scientific discovery tasks is limited by the accessibility of well-defined and labeled in-domain data. To tackle…

Machine Learning · Computer Science 2023-01-06 Ria Vinod , Pin-Yu Chen , Payel Das

Data augmentation for deep learning benefits model training, image transformation, medical imaging analysis and many other fields. Many existing methods generate new samples from a parametric distribution, like the Gaussian, with little…

Computer Vision and Pattern Recognition · Computer Science 2023-10-13 Elvis Han Cui , Bingbin Li , Yanan Li , Weng Kee Wong , Donghui Wang

Recently, particle-based variational inference (ParVI) methods have gained interest because they can avoid arbitrary parametric assumptions that are common in variational inference. However, many ParVI approaches do not allow arbitrary…

Machine Learning · Computer Science 2021-08-12 Neale Ratzlaff , Qinxun Bai , Li Fuxin , Wei Xu

We focus on generative autoencoders, such as variational or adversarial autoencoders, which jointly learn a generative model alongside an inference model. Generative autoencoders are those which are trained to softly enforce a prior on the…

Machine Learning · Computer Science 2017-01-13 Antonia Creswell , Kai Arulkumaran , Anil Anthony Bharath

Prostate cancer being one of the frequently diagnosed malignancy in men, the rising demand for biopsies places a severe workload on pathologists. The grading procedure is tedious and subjective, motivating the development of automated…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Riddhasree Bhattacharyya , Pallabi Dutta , Sushmita Mitra

Designing antibody sequences to better resemble those observed in natural human repertoires is a key challenge in biologics development. We introduce IgCraft: a multi-purpose model for paired human antibody sequence generation, built on…

Biomolecules · Quantitative Biology 2025-04-16 Matthew Greenig , Haowen Zhao , Vladimir Radenkovic , Aubin Ramon , Pietro Sormanni

We develop deep Poisson-gamma dynamical systems (DPGDS) to model sequentially observed multivariate count data, improving previously proposed models by not only mining deep hierarchical latent structure from the data, but also capturing…

Machine Learning · Statistics 2019-01-03 Dandan Guo , Bo Chen , Hao Zhang , Mingyuan Zhou

Generating diverse sequences is important in many NLP applications such as question generation or summarization that exhibit semantically one-to-many relationships between source and the target sequences. We present a method to explicitly…

Computation and Language · Computer Science 2019-09-05 Jaemin Cho , Minjoon Seo , Hannaneh Hajishirzi

Segmented models are widely used to describe non-stationary sequential data with discrete change points. Their estimation usually requires solving a mixed discrete-continuous optimization problem, where the segmentation is the discrete part…

Machine Learning · Computer Science 2021-01-19 Erik Scharwächter , Jonathan Lennartz , Emmanuel Müller

Histology analysis of the tumor micro-environment integrated with genomic assays is the gold standard for most cancers in modern medicine. This paper proposes a Gene-induced Multimodal Pre-training (GiMP) framework, which jointly…

Computer Vision and Pattern Recognition · Computer Science 2023-09-07 Ting Jin , Xingran Xie , Renjie Wan , Qingli Li , Yan Wang

Discrete distributions, particularly in high-dimensional deep models, are often highly multimodal due to inherent discontinuities. While gradient-based discrete sampling has proven effective, it is susceptible to becoming trapped in local…

Machine Learning · Computer Science 2024-10-28 Patrick Pynadath , Riddhiman Bhattacharya , Arun Hariharan , Ruqi Zhang