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Despite their significant advantages over competing technologies, nanopore sequencers are plagued by high error rates, due to physical characteristics of the nanopore and inherent noise in the biological processes. It is thus paramount not…

Information Theory · Computer Science 2025-10-27 Anisha Banerjee , Yonatan Yehezkeally , Antonia Wachter-Zeh , Eitan Yaakobi

Longitudinal resolution and lateral sensitivity are decisive characteristics that determine the suitability of a nanopore sensor for sequencing a strand of DNA as well as other important polymers. Previous modeling of DNA induced ionic…

Biological Physics · Physics 2012-05-18 Slaven Garaj , Song Liu , Daniel Branton , Jene A. Golovchenko

Nanopore genome sequencing is the key to enabling personalized medicine, global food security, and virus surveillance. The state-of-the-art base-callers adopt deep neural networks (DNNs) to translate electrical signals generated by nanopore…

Hardware Architecture · Computer Science 2020-08-10 Qian Lou , Sarath Janga , Lei Jiang

This paper proposes a practical successive decoding scheme with finite levels for the finite-state Markov channels where there is no a priori state information at the transmitter or the receiver. The design employs either a random…

Information Theory · Computer Science 2009-05-06 Teng Li , Oliver M. Collins

The paper studies optimal coding of hidden Markov sources (HMS), which represent a broad class of practical sources obtained through noisy acquisition processes, beside their explicit modeling use in speech processing and recognition, image…

Signal Processing · Electrical Eng. & Systems 2018-02-09 Mehdi Salehifar , Tejaswi Nanjundaswamy , Kenneth Rose

We consider approaches for controlling the buildup of noise by design of gates for chemical and biomolecular computing, in order to realize stable, scalable networks for multi-step information processing. Solvable rate-equation models are…

Biological Physics · Physics 2011-02-28 Vladimir Privman

DNA has many valuable characteristics that make it suitable for a long-term storage medium, in particular its durability and high information density. DNA can be stored safely for hundreds of years with virtually no degradation, in contrast…

Quantitative Methods · Quantitative Biology 2022-05-31 Jamie J. Alnasir , Thomas Heinis , Louis Carteron

Quantum multiparameter estimation involves estimating multiple parameters simultaneously and can be more precise than estimating them individually. Our interest here is to determine fundamental quantum limits to the achievable…

Quantum Physics · Physics 2019-03-26 Shibdas Roy

Recently, autoregressive neural vocoders have provided remarkable performance in generating high-fidelity speech and have been able to produce synthetic speech in real-time. However, autoregressive neural vocoders such as WaveFlow are…

Sound · Computer Science 2022-03-28 Manh Luong , Viet Anh Tran

The rapid advancement of generative AI has made it increasingly challenging to distinguish between deepfake audio and authentic human speech. To overcome the limitations of passive detection methods, we propose StreamMark, a novel deep…

Audio and Speech Processing · Electrical Eng. & Systems 2026-04-15 Zhentao Liu , Milos Cernak

Deep spectral methods reframe the image decomposition process as a graph partitioning task by extracting features using self-supervised learning and utilizing the Laplacian of the affinity matrix to obtain eigensegments. However, instance…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Farnoosh Arefi , Amir M. Mansourian , Shohreh Kasaei

This paper proposes a novel Sequence-to-Sequence (Seq2Seq) model integrating the structure of Hidden Semi-Markov Models (HSMMs) into its attention mechanism. In speech synthesis, it has been shown that methods based on Seq2Seq models using…

Audio and Speech Processing · Electrical Eng. & Systems 2021-09-01 Yoshihiko Nankaku , Kenta Sumiya , Takenori Yoshimura , Shinji Takaki , Kei Hashimoto , Keiichiro Oura , Keiichi Tokuda

In this paper, we design matched filters for diffusive molecular communication systems taking into account the following impairments: signal-dependent diffusion noise, inter-symbol interference (ISI), and external interfering molecules. The…

Information Theory · Computer Science 2017-05-05 Vahid Jamali , Arman Ahmadzadeh , Robert Schober

The last decade, nanopores have emerged as a new and interesting tool for the study of biological macromolecules like proteins and DNA. While biological pores, especially alpha-hemolysin, have been promising for the detection of DNA, their…

Biological Physics · Physics 2015-03-13 Ronald Kox , Stella Deheryan , Chang Chen , Nima Arjmandi , Liesbet Lagae , Gustaaf Borghs

Nanopore sequencing technology remains highly error-prone, making efficient error correction essential in DNA-based data storage. Prior work addressed high error rates using convolutional codes with their decoder coupled with the…

Information Theory · Computer Science 2026-04-02 Anisha Banerjee , Roman Sokolovskii , Thomas Heinis , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

DNA segments and sequences have been studied thoroughly during the past decades. One of the main problems in computational biology is the identification of exon-intron structures inside genes using mathematical techniques. Previous studies…

Applications · Statistics 2019-07-09 Pavlos Kolias , Alexandra Papadopoulou

With the rapid advancement of vision generation models, the potential security risks stemming from synthetic visual content have garnered increasing attention, posing significant challenges for AI-generated image detection. Existing methods…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Xinghan Li , Yue Yu , Xue Song , Haijun Shan , Jingjing Chen

The separation of single-channel underwater acoustic signals is a challenging problem with practical significance. Few existing studies focus on the source separation problem with unknown numbers of signals, and how to evaluate the…

Sound · Computer Science 2024-05-29 Qinggang Sun , Kejun Wang

Channel estimation is a critical task in multiple-input multiple-output (MIMO) digital communications that substantially effects end-to-end system performance. In this work, we introduce a novel approach for channel estimation using deep…

Signal Processing · Electrical Eng. & Systems 2022-11-09 Marius Arvinte , Jonathan I Tamir

In this paper, we formally define and analyze the class of noisy permutation channels. The noisy permutation channel model constitutes a standard discrete memoryless channel (DMC) followed by an independent random permutation that reorders…

Information Theory · Computer Science 2020-07-16 Anuran Makur
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