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We report a development of a new fast surface-based method for numerical calculations of solvation energy of biomolecules with a large number of charged groups. The procedure scales linearly with the system size both in time and memory…

Quantitative Methods · Quantitative Biology 2011-07-25 P. O. Fedichev , E. G. Getmantsev , L. I. Men'shikov

The effective potential formalism is applied to glass forming liquids, choosing a coupling potential such that the "order parameter", conjugated to the coupling strength, is the mean square displacement of the particles from their position…

Disordered Systems and Neural Networks · Physics 2007-05-23 Antonio de Candia

Estimating the free energy in molecular simulation requires, implicitly or explicitly, counting how many times the system is observed in a finite region. If the simulation is biased by an external potential, the weight of the configurations…

Chemical Physics · Physics 2021-12-22 Matteo Carli , Alessandro Laio

Based on an analysis of the short range chemical environment of each atom in a system, standard machine learning based approaches to the construction of interatomic potentials aim at determining directly the central quantity which is the…

Materials Science · Physics 2015-08-05 S. Alireza Ghasemi , Albert Hofstetter , Santanu Saha , Stefan Goedecker

The authors present a new molecular dynamics algorithm for sampling the isothermal-isobaric ensemble. In this approach the velocities of all particles and volume degrees of freedom are rescaled by a properly chosen random factor. The…

Statistical Mechanics · Physics 2009-03-10 Giovanni Bussi , Tatyana Zykova-Timan , Michele Parrinello

The pressure-temperature phase diagram of a one-component system, with particles interacting through a spherically symmetric pair potential is studied. It is shown that if the pair potential allows for a discontinuous reduction of the…

Statistical Mechanics · Physics 2008-02-03 E. A. Jagla

The formal structure of geometrical thermodynamics is reviewed with particular emphasis on the geometry of equilibria submanifolds. On these submanifolds thermodynamic metrics are defined as the Hessian of thermodynamic potentials. Links…

Mathematical Physics · Physics 2007-05-23 Manuel Santoro , Albert S. Benight

Understanding thermodynamics in liquids at the atomic level is challenging because of strong atomic interactions and lack of symmetry. Recent prior theoretical works have focused on describing heat capacity of liquids in terms of…

Disordered Systems and Neural Networks · Physics 2022-10-14 Jaeyun Moon , Simon Thébaud , Lucas Lindsay , Takeshi Egami

In the statistical mechanics of quantum harmonic oscillators, the zero-point energy can either be included (Schr\"odinger oscillators) or omitted (Planck oscillators). For the usual results, the type of oscillator makes no difference but,…

General Physics · Physics 2019-09-27 Enrique N. Miranda

Open-system density functional theory may be formulated in terms of ensemble averages arising from interaction with a bath. The system is allowed to exchange particles with the bath and the states in the ensemble average are those…

Materials Science · Physics 2007-05-23 Steven M. Valone

Chemical potential is an effective way to drive phase transition or express wettability. In this letter, we present a chemical-potential-based lattice Boltzmann model to simulate multiphase flows. The nonideal force is directly evaluated by…

Computational Physics · Physics 2017-06-21 Binghai Wen , Xuan Zhou , Bing He , Chaoying Zhang , Haiping Fang

We present a family of alchemical perturbation potentials that enable the calculation of hydration free energies of small to medium-sized molecules in a concerted single alchemical coupling step instead of the commonly used sequence of two…

Quantitative Methods · Quantitative Biology 2021-02-24 Sheenam Khuttan , Solmaz Azimi , Joe Z. Wu , Emilio Gallicchio

Aqueous lithium chloride solutions up to very high concentrations were investigated in classical molecular dynamics simulations. Various force fields based on the 12-6 Lennard-Jones model, parametrized for non-polarizable water solvent…

Soft Condensed Matter · Physics 2017-07-31 Ildikó Pethes

Molecular dynamics simulations are used to generate an ensemble of saddles of the potential energy of a Lennard-Jones liquid. Classifying all extrema by their potential energy u and number of unstable directions k, a well defined relation…

Statistical Mechanics · Physics 2009-10-31 Kurt Broderix , Kamal K. Bhattacharya , Andrea Cavagna , Annette Zippelius , Irene Giardina

The hybrid form is a combination of the Rydberg potential and the London inverse-sixth-power energy. It is accurate at all relevant distance scales and simple enough for use in all-atom simulations of biomolecules. One may compute the…

Biomolecules · Quantitative Biology 2009-11-13 Kevin Cahill

We use the two-flavor linear sigma model with quarks to study the phase structure of isospin asymmetric matter at zero temperature. The meson degrees of freedom provide the mean field chiral- and isospin-condensates on top of which we…

High Energy Physics - Phenomenology · Physics 2023-05-03 Alejandro Ayala , Aritra Bandyopadhyay , Ricardo L. S. Farias , Luis A. Hernández , José Luis Hernández

Phase diagrams serve as a highly informative tool for materials design, encapsulating information about the phases that a material can manifest under specific conditions. In this work, we develop a method in which Bayesian inference is…

Materials Science · Physics 2023-09-06 Timofei Miryashkin , Olga Klimanova , Vladimir Ladygin , Alexander Shapeev

The Gibbs free energy is the fundamental thermodynamic potential underlying the relative stability of different states of matter under constant-pressure conditions. However, computing this quantity from atomic-scale simulations is far from…

Materials Science · Physics 2018-02-14 Bingqing Cheng , Michele Ceriotti

Extending to continuous potentials a cleaving wall molecular-dynamics simulation method recently developed for the hard-sphere system [Phys.Rev.Lett 85, 4751 (2000)], we calculate the crystal-melt interfacial free energies, $\gamma$, for a…

Materials Science · Physics 2009-11-10 Ruslan L. Davidchack , Brian B. Laird

Classical density-functional theory is the most direct approach to equilibrium structures and free energies of inhomogeneous liquids, but requires the construction of an approximate free-energy functional for each liquid of interest. We…

Soft Condensed Matter · Physics 2014-10-10 Ravishankar Sundararaman , Kendra Letchworth-Weaver , T A Arias
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