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Bayesian profile regression mixture models (BPRM) allow to assess a health risk in a multi-exposed population. These mixture models cluster individuals according to their exposure profile and their health risk. However, their results, based…

Methodology · Statistics 2025-12-30 Fendler Julie , Guihenneuc Chantal , Ancelet Sophie

Subpopulation shift exists widely in many real-world applications, which refers to the training and test distributions that contain the same subpopulation groups but with different subpopulation proportions. Ignoring subpopulation shifts…

Machine Learning · Computer Science 2023-04-11 Zongbo Han , Zhipeng Liang , Fan Yang , Liu Liu , Lanqing Li , Yatao Bian , Peilin Zhao , Qinghua Hu , Bingzhe Wu , Changqing Zhang , Jianhua Yao

Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

Quantitative Methods · Quantitative Biology 2022-04-18 Alan D. Kaplan , Uttara Tipnis , Jean C. Beckham , Nathan A. Kimbrel , David W. Oslin , Benjamin H. McMahon

Intercurrent events, common in clinical trials and observational studies, affect the existence or interpretation of final outcomes. Principal stratification addresses this challenge by defining local average treatment effect estimands…

Methodology · Statistics 2025-09-22 Jiaqi Tong , Brennan Kahan , Michael O. Harhay , Fan Li

Considerable interest has recently been focused on studying multiple phenotypes simultaneously in both epidemiological and genomic studies, either to capture the multidimensionality of complex disorders or to understand shared etiology of…

Methodology · Statistics 2015-11-26 Denis Agniel , Katherine P. Liao , Tianxi Cai

Empirical best linear unbiased prediction (EBLUP) method uses a linear mixed model in combining information from different sources of information. This method is particularly useful in small area problems. The variability of an EBLUP is…

Statistics Theory · Mathematics 2008-12-18 Snigdhansu Chatterjee , Partha Lahiri , Huilin Li

Multi-behavior recommendation faces a critical challenge in practice: auxiliary behaviors (e.g., clicks, carts) are often noisy, weakly correlated, or semantically misaligned with the target behavior (e.g., purchase), which leads to biased…

Information Retrieval · Computer Science 2026-01-22 Miaomiao Cai , Zhijie Zhang , Junfeng Fang , Zhiyong Cheng , Xiang Wang , Meng Wang

Large language models (LLMs) are currently aligned using techniques such as reinforcement learning from human feedback (RLHF). However, these methods use scalar rewards that can only reflect user preferences on average. Pluralistic…

Computation and Language · Computer Science 2025-08-13 Jadie Adams , Brian Hu , Emily Veenhuis , David Joy , Bharadwaj Ravichandran , Aaron Bray , Anthony Hoogs , Arslan Basharat

Researchers often use linear regression to analyse randomized experiments to improve treatment effect estimation by adjusting for imbalances of covariates in the treatment and control groups. Our work offers a randomization-based inference…

Statistics Theory · Mathematics 2022-07-08 Hanzhong Liu , Yuehan Yang

The integration of data from multiple sources is increasingly used to achieve larger sample sizes and enhance population diversity. Our previous work established that, under random sampling from the same underlying population, integrating…

Methodology · Statistics 2026-01-01 Farimah Shamsi , Andriy Derkach

Contextual sensing and delivery of digital interventions to improve health outcomes have gained significant traction in behavioral and psychiatric studies. Micro-randomized trials (MRTs) are a common experimental design for obtaining…

Methodology · Statistics 2025-04-01 Jieru Shi , Zhenke Wu , Walter Dempsey

Estimating the prevalence of a category in a population using imperfect measurement devices (diagnostic tests, classifiers, or large language models) is fundamental to science, public health, and online trust and safety. Standard approaches…

Artificial Intelligence · Computer Science 2026-04-24 Fridolin Linder , Thomas Leeper , Daniel Haimovich , Niek Tax , Lorenzo Perini , Milan Vojnovic

Minimum Bayes Risk (MBR) decoding is a method for choosing the outputs of a machine learning system based not on the output with the highest probability, but the output with the lowest risk (expected error) among multiple candidates. It is…

Computation and Language · Computer Science 2023-10-03 Amanda Bertsch , Alex Xie , Graham Neubig , Matthew R. Gormley

Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science. In…

Applications · Statistics 2019-01-03 Qingyuan Zhao , Jingshu Wang , Gibran Hemani , Jack Bowden , Dylan S. Small

In this paper, we explore model-based approach to training robust and interpretable binarized regression models for multiclass classification tasks using Mixed-Integer Programming (MIP). Our MIP model balances the optimization of prediction…

Machine Learning · Computer Science 2022-03-22 Sanjana Tule , Nhi Ha Lan Le , Buser Say

Models trained with empirical risk minimization (ERM) are prone to be biased towards spurious correlations between target labels and bias attributes, which leads to poor performance on data groups lacking spurious correlations. It is…

Machine Learning · Computer Science 2024-12-23 Hyeonggeun Han , Sehwan Kim , Hyungjun Joo , Sangwoo Hong , Jungwoo Lee

Neural network learning is usually time-consuming since backpropagation needs to compute full gradients and backpropagate them across multiple layers. Despite its success of existing works in accelerating propagation through sparseness, the…

Machine Learning · Computer Science 2020-10-28 Zhiyuan Zhang , Pengcheng Yang , Xuancheng Ren , Qi Su , Xu Sun

We develop a novel and general framework for reduced-bias $M$-estimation from asymptotically unbiased estimating functions. The framework relies on an empirical approximation of the bias by a function of derivatives of estimating function…

Methodology · Statistics 2023-08-11 Ioannis Kosmidis , Nicola Lunardon

Non-linear hierarchical models are commonly used in many disciplines. However, inference in the presence of non-nested effects and on large datasets is challenging and computationally burdensome. This paper provides two contributions to…

Methodology · Statistics 2021-10-22 Max Goplerud

In many contexts, there is interest in selecting the most important variables from a very large collection, commonly referred to as support recovery or variable, feature or subset selection. There is an enormous literature proposing a rich…

Computation · Statistics 2015-06-23 Willem van den Boom , Galen Reeves , David B. Dunson
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