Related papers: Spray characteristics from nasal spray atomization
Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques.…
Improving the efficacy of nasal sprays by enhancing targeted drug delivery to intra-airway tissue sites prone to infection onset is hypothesized to be achievable through an optimization of key device and formulation parameters, such as the…
Introduction: Topical intranasal drugs are widely prescribed for Chronic Rhinosinusitis (CRS), although delivery can vary with device type and droplet size. The study objective was to compare nebulized and sprayed droplet deposition in the…
Airflow through the nasal cavity exhibits a wide variety of fluid dynamicsbehaviour due to the intricacy of the nasal geometry. The flow is naturallyunsteady and perhaps turbulent, despite CFD in the literature that assumesa steady laminar…
Background: Chronic rhinosinusitis (CRS) is a prevalent and disruptive disease. Medical management including nasal steroid sprays is the primary treatment modality. Computational fluid dynamics (CFD) has been used to characterize sinonasal…
Spray atomization process involves complex multi-phase phenomena. Abundant literature and validation of spray modelling for industrial applications like fuel injection in internal combustion and turbine jet engines are available. However,…
This paper presents a CFD study of Engine Combustion Network (ECN) Spray G, focusing on the transient characteristics of spray at start of injection. The Large Eddy Simulation (LES) coupled with Volume of Fluid (VOF) method is used to model…
Efficacy for COVID-19 treatments can be enhanced significantly through targeting the nasopharynx, which has been shown to be the dominant preliminary infection site for SARS-CoV-2. Although intranasal drugs can be administered easily…
Nasal breathing difficulties (NBD) are widespread and difficult to diagnose; the failure rate of their surgical corrections is high. Computational Fluid Dynamics (CFD) enables diagnosis of NBD and surgery planning, by comparing a…
Generating anatomically realistic three-dimensional (3D) models of the human sinonasal cavity for numerical investigations of sprayed drug transport presents a host of methodological ambiguities. For example, subject-specific radiographic…
Computational fluid dynamics of the air flow in the human nasal cavities, starting from patient-specific Computer Tomography (CT) scans, is an important tool for diagnostics and surgery planning. However, a complete and systematic…
The study is looking into the potential of using computational fluid dynamics (CFD) as a tool for predicting the outcome of surgery for alleviation of obstructive sleep apnea syndrome (OSAS). From pre- and post-operative computed tomography…
Purpose: Nasal saline irrigation is highly recommended in patients following functional endoscopic sinus surgery (FESS) to aid the postoperative recovery. Post-FESS patients have significantly altered anatomy leading to markedly different…
Spray characterization often relies on empirical formulas, statistical distributions, and derived quantities. Deterministic spray behavior originates from physics-governed mechanisms of atomization, \emph{e.g.}, nozzle geometry, boundary…
In several problems involving fluid flows, Computational Fluid Dynamics (CFD) provides detailed quantitative information, and often allows the designer to successfully optimize the system, by minimizing a cost function. Sometimes, however,…
Objectives: The main objective of this review article is to evaluate the usability of Computational Fluid Dynamics (CFD) as a supporting clinical tool for respiratory system. Data Source: The English articles referred for this review paper…
Spray drop size distribution generated by atomization of fuel influences several facets of a combustion process such as, fuel-air mixing, reaction kinetics and thrust generation. In a typical spray, the drop size distribution evolves…
The prediction of the drop size distribution (DSD) resulting from liquid atomization is key to the optimization of multi-phase flows, from gas-turbine propulsion, through agriculture, to healthcare. Obtaining high-fidelity data of liquid…
Electrospray technology enables external electric fields to steer charged droplets, with potential applications in fuel-air mixing and aerodynamic flow control. This study develops a computational framework that couples a steady OpenFOAM…
Flash-boiling injection is one of the most effective ways to accomplish improved atomization compared to the high-pressure injection strategy. The tiny droplets formed via flash-boiling lead to fast fuel-air mixing and can subsequently…