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Compressed suffix arrays (CSAs) index large repetitive collections and are key in many text applications. The r-index and its derivatives combine the run-length Burrows-Wheeler Transform (BWT) with suffix array sampling to achieve space…

Data Structures and Algorithms · Computer Science 2026-02-20 Diego Díaz-Domínguez , Veli Mäkinen

Mutual Information (MI) based feature selection makes use of MI to evaluate each feature and eventually shortlists a relevant feature subset, in order to address issues associated with high-dimensional datasets. Despite the effectiveness of…

Machine Learning · Computer Science 2022-12-20 Shiyu Liu , Mehul Motani

Matching statistics were introduced to solve the approximate string matching problem, which is a recurrent subroutine in bioinformatics applications. In 2010, Ohlebusch et al. [SPIRE 2010] proposed a time and space efficient algorithm for…

Data Structures and Algorithms · Computer Science 2023-01-16 Alessio Conte , Nicola Cotumaccio , Travis Gagie , Giovanni Manzini , Nicola Prezza , Marinella Sciortino

The Burrows-Wheeler Transform (BWT) has been an essential tool in text compression and indexing. First introduced in 1994, it went on to provide the backbone for the first encoding of the classic suffix tree data structure in space close to…

Data Structures and Algorithms · Computer Science 2020-02-19 Jason Bentley , Daniel Gibney , Sharma V. Thankachan

Indexing is an effective way to support efficient query processing in large databases. Recently the concept of learned index, which replaces or complements traditional index structures with machine learning models, has been actively…

Databases · Computer Science 2022-08-01 Yao Tian , Tingyun Yan , Xi Zhao , Kai Huang , Xiaofang Zhou

Regular expression matching is of practical importance due to its widespread use in real-world applications. In practical use, regular expressions are often used with real-world extensions. Accordingly, the matching problem of regular…

Formal Languages and Automata Theory · Computer Science 2025-07-03 Taisei Nogami , Tachio Terauchi

Mixture Markov Model (MMM) is a widely used tool to cluster sequences of events coming from a finite state-space. However the MMM likelihood being multi-modal, the challenge remains in its maximization. Although Expectation-Maximization…

Optimization and Control · Mathematics 2026-04-16 Priyam Das , Deborshee Sen , Debsurya De , Jue Hou , Zahra S. H. Abad , Nicole Kim , Zongqi Xia , Tianxi Cai

The Mixture-of-Experts (MoE) model has emerged as a prominent architecture in the field of Large Language Models (LLMs), providing a better balance between model performance and computational efficiency. However the General Matrix Multiply…

Computation and Language · Computer Science 2025-01-06 Yulei Qian , Fengcun Li , Xiangyang Ji , Xiaoyu Zhao , Jianchao Tan , Kefeng Zhang , Xunliang Cai

Recently, a compressed index for similar strings, called the FM-index of alignment (FMA), has been proposed with the functionalities of pattern search and random access. The FMA is quite efficient in space requirement and pattern search…

Data Structures and Algorithms · Computer Science 2016-06-14 Joong Chae Na , Hyunjoon Kim , Seunghwan Min , Heejin Park , Thierry Lecroq , Martine Leonard , Laurent Mouchardd , Kunsoo Park

In this article, we propose two classes of semiparametric mixture regression models with single-index for model based clustering. Unlike many semiparametric/nonparametric mixture regression models that can only be applied to low dimensional…

Methodology · Statistics 2017-08-15 Sijia Xiang , Weixin Yao

The resurgence of near-memory processing (NMP) with the advent of big data has shifted the computation paradigm from processor-centric to memory-centric computing. To meet the bandwidth and capacity demands of memory-centric computing, 3D…

Hardware Architecture · Computer Science 2021-04-29 Pritam Majumder , Jiayi Huang , Sungkeun Kim , Abdullah Muzahid , Dylan Siegers , Chia-Che Tsai , Eun Jung Kim

This paper describes an algorithm for fitting finite mixtures of unrestricted Multivariate Skew t (FM-uMST) distributions. The package EMMIX-uskew implements a closed-form expectation-maximization (EM) algorithm for computing the maximum…

Computation · Statistics 2013-03-29 Sharon X. Lee , Geoffrey J. McLachlan

Item indexing, which maps a large corpus of items into compact discrete representations, is critical for both discriminative and generative recommender systems, yet existing Vector Quantization (VQ)-based approaches struggle with the highly…

Information Retrieval · Computer Science 2026-01-29 Jing Yan , Yimeng Bai , Zongyu Liu , Yahui Liu , Junwei Wang , Jingze Huang , Haoda Li , Sihao Ding , Shaohui Ruan , Yang Zhang

The two most common data-structures for genome indexing, FM-indices and hash-tables, exhibit a fundamental trade-off between memory footprint and performance. We present Ranger, a new indexing technique for nucleotide sequences that is both…

Data Structures and Algorithms · Computer Science 2023-08-09 Alon Rashelbach , Ori Rottensterich , Mark Silberstien

Metagenomics characterizes the taxonomic diversity of microbial communities by sequencing DNA directly from an environmental sample. One of the main challenges in metagenomics data analysis is the binning step, where each sequenced read is…

Quantitative Methods · Quantitative Biology 2015-05-27 Kévin Vervier , Pierre Mahé , Maud Tournoud , Jean-Baptiste Veyrieras , Jean-Philippe Vert

We propose a general method for optimally approximating an arbitrary matrix $\mathbf{M}$ by a structured matrix $\mathbf{T}$ (circulant, Toeplitz/Hankel, etc.) and examine its use for estimating the spectra of genomic linkage disequilibrium…

Applications · Statistics 2024-09-10 Chris Salahub , Jeffrey Uhlmann

The Matrix Multiplicative Weight Update (MMWU) is a seminal online learning algorithm with numerous applications. Applied to the matrix version of the Learning from Expert Advice (LEA) problem on the $d$-dimensional spectraplex, it is well…

Machine Learning · Computer Science 2025-09-12 Weiyuan Gong , Tongyang Li , Xinzhao Wang , Zhiyu Zhang

Mixtures-of-Experts (MoE) are conditional mixture models that have shown their performance in modeling heterogeneity in data in many statistical learning approaches for prediction, including regression and classification, as well as for…

Methodology · Statistics 2019-07-17 Bao Tuyen Huynh , Faicel Chamroukhi

Advances in DNA sequencing technology have stimulated the development of algorithms and tools for processing very large collections of short strings (reads). Short-read alignment and assembly are among the most well-studied problems. Many…

Genomics · Quantitative Biology 2014-01-30 Chi-Man Liu , Ruibang Luo , Tak-Wah Lam

Merge trees are a valuable tool in the scientific visualization of scalar fields; however, current methods for merge tree comparisons are computationally expensive, primarily due to the exhaustive matching between tree nodes. To address…

Machine Learning · Computer Science 2024-10-07 Yu Qin , Brittany Terese Fasy , Carola Wenk , Brian Summa
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