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Effective therapy of complex diseases requires control of highly non-linear complex networks that remain incompletely characterized. In particular, drug intervention can be seen as control of signaling in cellular networks. Identification…

Quantitative Methods · Quantitative Biology 2009-09-03 Jacob D. Feala , Jorge Cortes , Phillip M. Duxbury , Carlo Piermarocchi , Andrew D. McCulloch , Giovanni Paternostro

In all but the most trivial optimization problems, the structure of the solutions exhibit complex interdependencies between the input parameters. Decades of research with stochastic search techniques has shown the benefit of explicitly…

Neural and Evolutionary Computing · Computer Science 2017-03-23 Shumeet Baluja

Neural Combinatorial Optimization (NCO) is an emerging domain where deep learning techniques are employed to address combinatorial optimization problems as a standalone solver. Despite their potential, existing NCO methods often suffer from…

Neural and Evolutionary Computing · Computer Science 2024-08-06 Andoni I. Garmendia , Quentin Cappart , Josu Ceberio , Alexander Mendiburu

Optimization networks are a new methodology for holistically solving interrelated problems that have been developed with combinatorial optimization problems in mind. In this contribution we revisit the core principles of optimization…

Efficiently tackling combinatorial reasoning problems, particularly the notorious NP-hard tasks, remains a significant challenge for AI research. Recent efforts have sought to enhance planning by incorporating hierarchical high-level search…

Deep Neural Networks and Reinforcement Learning methods have empirically shown great promise in tackling challenging combinatorial problems. In those methods a deep neural network is used as a solution generator which is then trained by…

Machine Learning · Computer Science 2023-11-08 Constantine Caramanis , Dimitris Fotakis , Alkis Kalavasis , Vasilis Kontonis , Christos Tzamos

Combinatorial games lead to several interesting, clean problems in algorithms and complexity theory, many of which remain open. The purpose of this paper is to provide an overview of the area to encourage further research. In particular, we…

Computational Complexity · Computer Science 2009-09-25 Erik D. Demaine , Robert A. Hearn

Combinatorial optimization finds an optimal solution within a discrete set of variables and constraints. The field has seen tremendous progress both in research and industry. With the success of deep learning in the past decade, a recent…

Machine Learning · Computer Science 2023-11-27 Mehdi Seyfi , Amin Banitalebi-Dehkordi , Zirui Zhou , Yong Zhang

Algorithms have been fundamental to recent global technological advances and, in particular, they have been the cornerstone of technical advances in one field rapidly being applied to another. We argue that algorithms possess fundamentally…

Machine Learning · Computer Science 2021-08-09 Petar Veličković , Charles Blundell

Combinatorial optimization is a challenging problem applicable in a wide range of fields from logistics to finance. Recently, quantum computing has been used to attempt to solve these problems using a range of algorithms, including…

Quantum Physics · Physics 2024-03-06 Jonathan Wurtz , Stefan Sack , Sheng-Tao Wang

Neural algorithmic reasoning is an emerging area of machine learning focusing on building models that can imitate the execution of classic algorithms, such as sorting, shortest paths, etc. One of the main challenges is to learn algorithms…

Machine Learning · Computer Science 2023-11-02 Gleb Rodionov , Liudmila Prokhorenkova

Robust optimization is becoming increasingly important in machine learning applications. In this paper, we study a unified framework of robust submodular optimization. We study this problem both from a minimization and maximization…

Machine Learning · Computer Science 2021-03-22 Rishabh Iyer

Graphs are a natural representation for systems based on relations between connected entities. Combinatorial optimization problems, which arise when considering an objective function related to a process of interest on discrete structures,…

Machine Learning · Computer Science 2024-08-21 Victor-Alexandru Darvariu , Stephen Hailes , Mirco Musolesi

Neural Combinatorial Optimization has been researched actively in the last eight years. Even though many of the proposed Machine Learning based approaches are compared on the same datasets, the evaluation protocol exhibits essential flaws…

Machine Learning · Computer Science 2023-10-09 Daniela Thyssens , Tim Dernedde , Jonas K. Falkner , Lars Schmidt-Thieme

Many real-world systems problems require reasoning about the long term consequences of actions taken to configure and manage the system. These problems with delayed and often sequentially aggregated reward, are often inherently…

Machine Learning · Computer Science 2019-09-06 Ameer Haj-Ali , Nesreen K. Ahmed , Ted Willke , Joseph Gonzalez , Krste Asanovic , Ion Stoica

In the last few years, the formulation of real-world optimization problems and their efficient solution via metaheuristic algorithms has been a catalyst for a myriad of research studies. In spite of decades of historical advancements on the…

Metaheuristic algorithms are becoming an important part of modern optimization. A wide range of metaheuristic algorithms have emerged over the last two decades, and many metaheuristics such as particle swarm optimization are becoming…

Optimization and Control · Mathematics 2012-12-04 Xin-She Yang

Learning heuristics for combinatorial optimization problems through graph neural networks have recently shown promising results on some classic NP-hard problems. These are single-level optimization problems with only one player. Multilevel…

Machine Learning · Computer Science 2023-04-22 Adel Nabli , Margarida Carvalho

Classic algorithms and machine learning systems like neural networks are both abundant in everyday life. While classic computer science algorithms are suitable for precise execution of exactly defined tasks such as finding the shortest path…

Machine Learning · Computer Science 2022-09-02 Felix Petersen

This paper surveys the machine learning literature and presents in an optimization framework several commonly used machine learning approaches. Particularly, mathematical optimization models are presented for regression, classification,…

Optimization and Control · Mathematics 2021-01-12 Claudio Gambella , Bissan Ghaddar , Joe Naoum-Sawaya