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Neyman and Pearson's theory of testing hypotheses does not warrant minimal epistemic reliability: the feature of driving to true conclusions more often than to false ones. The theory does not protect from the possible negative effects of…

Statistics Theory · Mathematics 2021-07-07 Adam P. Kubiak , Pawel Kawalec , Adam Kiersztyn

In a recent opinion article, Muff et al. recapitulate well-known objections to the Neyman-Pearson Null-Hypothesis Significance Testing (NHST) framework and call for reforming our practices in statistical reporting. We agree with them on…

Quantitative Methods · Quantitative Biology 2022-05-30 Florian Hartig , Frédéric Barraquand

P-hacking is prevalent in reality but absent from classical hypothesis testing theory. As a consequence, significant results are much more common than they are supposed to be when the null hypothesis is in fact true. In this paper, we build…

Econometrics · Economics 2024-05-09 Adam McCloskey , Pascal Michaillat

E-values have gained prominence as flexible tools for statistical inference and risk control, enabling anytime- and post-hoc-valid procedures under minimal assumptions. However, many real-world applications fundamentally rely on sensitive…

Methodology · Statistics 2025-10-22 Daniel Csillag , Diego Mesquita

A/B testing is ubiquitous within the machine learning and data science operations of internet companies. Generically, the idea is to perform a statistical test of the hypothesis that a new feature is better than the existing platform---for…

Statistics Theory · Mathematics 2017-10-11 David Goldberg , James E. Johndrow

Increased availability of data and accessibility of computational tools in recent years have created unprecedented opportunities for scientific research driven by statistical analysis. Inherent limitations of statistics impose constrains on…

Genomics · Quantitative Biology 2016-09-13 Olga A. Vsevolozhskaya , Gabriel Ruiz , Dmitri V. Zaykin

In the context of supervised parametric models, we introduce the concept of e-values. An e-value is a scalar quantity that represents the proximity of the sampling distribution of parameter estimates in a model trained on a subset of…

Machine Learning · Statistics 2022-07-19 Subhabrata Majumdar , Snigdhansu Chatterjee

E-variables are nonnegative random variables with expected value at most one under any distribution from a given null hypothesis. Every nonasymptotically valid test can be obtained by thresholding some e-variable. As such, e-variables arise…

Statistics Theory · Mathematics 2026-02-06 Martin Larsson , Aaditya Ramdas , Johannes Ruf

In this study, we propose a two-stage procedure for hypothesis testing, where the first stage is conventional hypothesis testing and the second is an equivalence testing procedure using an introduced Empirical Equivalence Bound. In 2016,…

Methodology · Statistics 2020-01-01 Yi Zhao , Brian S. Caffo , Joshua B. Ewen

Null hypothesis significance tests and p values are widely used despite very strong arguments against their use in many contexts. Confidence intervals are often recommended as an alternative, but these do not achieve the objective of…

Methodology · Statistics 2014-02-12 Michael Wood

We develop a representation of a decision maker's uncertainty based on e-variables. Like the Bayesian posterior, this *e-posterior* allows for making predictions against arbitrary loss functions that may not be specified ex ante. Unlike the…

Statistics Theory · Mathematics 2023-09-20 Peter Grünwald

A/B tests are typically analyzed via frequentist p-values and confidence intervals; but these inferences are wholly unreliable if users endogenously choose samples sizes by *continuously monitoring* their tests. We define *always valid*…

Statistics Theory · Mathematics 2019-07-18 Ramesh Johari , Leo Pekelis , David J. Walsh

The notion of an e-value has been recently proposed as a possible alternative to critical regions and p-values in statistical hypothesis testing. In this paper we consider testing the nonparametric hypothesis of symmetry, introduce…

Statistics Theory · Mathematics 2024-01-29 Vladimir Vovk , Ruodu Wang

A typical power calculation is performed by replacing unknown population-level quantities in the power function with what is observed in external studies. Many authors and practitioners view this as an assumed value of power and offer the…

Applications · Statistics 2026-05-12 Geoffrey S Johnson

While generative models, especially large language models (LLMs), are ubiquitous in today's world, principled mechanisms to assess their (in)correctness are limited. Using the conformal prediction framework, previous works construct sets of…

Machine Learning · Statistics 2026-04-02 Guneet S. Dhillon , Javier González , Teodora Pandeva , Alicia Curth

Significance testing based on p-values has been implicated in the reproducibility crisis in scientific research, with one of the proposals being to eliminate them in favor of Bayesian analyses. Defenders of the p-values have countered that…

Methodology · Statistics 2023-05-02 Christos Argyropoulos , Andy P Grieve

We examine the role of trustworthiness and trust in statistical inference, arguing that it is the extent of trustworthiness in inferential statistical tools which enables trust in the conclusions. Certain tools, such as the p-value and…

Methodology · Statistics 2021-05-11 David J. Hand

A pervasive issue in statistical hypothesis testing is that the reported $p$-values are biased downward by data "peeking" -- the practice of reporting only progressively extreme values of the test statistic as more data samples are…

Statistics Theory · Mathematics 2020-11-04 Akshay Balsubramani

E-values have recently emerged as a robust and flexible alternative to p-values for hypothesis testing, especially under optional continuation, i.e., when additional data from further experiments are collected. In this work, we define…

Methodology · Statistics 2025-09-03 Francesca Giuffrida , Diego Garlaschelli , Peter Grünwald

Simultaneous testing of one hypothesis at multiple alpha levels can be performed within a conventional Neyman-Pearson framework. This is achieved by treating the hypothesis as a family of hypotheses, each member of which explicitly concerns…

Applications · Statistics 2024-08-01 Janet Aisbett