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Information storage, reflecting the capability of a dynamical system to keep predictable information during its evolution over time, is a key element of intrinsic distributed computation, useful for the description of the dynamical…

The network representation is becoming increasingly popular for the description of cardiovascular interactions based on the analysis of multiple simultaneously collected variables. However, the traditional methods to assess network links…

Objective: This work introduces a framework for multivariate time series analysis aimed at detecting and quantifying collective emerging behaviors in the dynamics of physiological networks. Methods: Given a network system mapped by a vector…

Applications · Statistics 2025-02-04 Luca Faes , Gorana Mijatovic , Laura Sparacino , Alberto Porta

Exploiting the theory of state space models, we derive the exact expressions of the information transfer, as well as redundant and synergistic transfer, for coupled Gaussian processes observed at multiple temporal scales. All of the terms,…

Methodology · Statistics 2017-08-21 Luca Faes , Daniele Marinazzo , Sebastiano Stramaglia

We present the multiscale entropy analysis of short term physiological time series of simultaneously acquired samples of heart rate, blood pressure and lung volume, from healthy subjects and from subjects with Chronic Heart Failure.…

Medical Physics · Physics 2007-05-23 L. Angelini , R. Maestri , D. Marinazzo , L. Nitti , M. Pellicoro , G. D. Pinna , S. Stramaglia , S. A. Tupputi

In the study of complex physical and physiological systems represented by multivariate time series, an issue of great interest is the description of the system dynamics over a range of different temporal scales. While information-theoretic…

Information Theory · Computer Science 2016-02-25 Luca Faes , Alessandro Montalto , Sebastiano Stramaglia , Giandomenico Nollo , Daniele Marinazzo

Signals from heart transplant recipients can be considered to be a natural source of information for a better understanding of the impact of the autonomic nervous system on the complexity of heart rate variability. Beat-to-beat heart rate…

Recent advances in signal processing and information theory are boosting the development of new approaches for the data-driven modelling of complex network systems. In the fields of Network Physiology and Network Neuroscience where the…

Methodology · Statistics 2024-01-23 Laura Sparacino , Yuri Antonacci , Gorana Mijatovic , Luca Faes

Causal inference seeks to identify cause-and-effect interactions in coupled systems. A recently proposed method by Liang detects causal relations by quantifying the direction and magnitude of information flow between time series. The…

Data Analysis, Statistics and Probability · Physics 2024-03-20 Dionissios T. Hristopulos

Several data-driven approaches based on information theory have been proposed for analyzing high-order interactions involving three or more components of a network system. Most of these methods are defined only in the time domain and rely…

Applications · Statistics 2025-03-18 Yuri Antonacci , Chiara Bara' , Laura Sparacino , Gorana Mijatovic , Ludovico Minati , Luca Faes

Prenatal maternal stress alters maternal-fetal heart rate coupling, as demonstrated by the Fetal Stress Index derived from bivariate phase-rectified signal averaging. Here, we extend this framework using information-theoretical measures to…

Quantitative Methods · Quantitative Biology 2026-01-05 Nicolas B. Garnier , Maria S. Molinet , Marta C. Antonelli , Silvia M. Lobmaier , Martin G. Frasch

Complex systems are often characterized by the interplay of multiple interconnected dynamical processes operating across a range of temporal scales. This phenomenon is widespread in both biological and artificial scenarios, making it…

Statistical Mechanics · Physics 2025-09-08 Giorgio Nicoletti , Daniel M. Busiello

Understanding a complex system entails capturing the non-trivial collective phenomena that arise from interactions between its different parts. Information theory is a flexible and robust framework to study such behaviours, with several…

Electrical communication between cardiomyocytes can be perturbed during arrhythmia, but these perturbations are not captured by conventional electrocardiographic metrics. We developed a theoretical framework to quantify electrical…

We propose a unified theoretical framework for quantifying spatio-temporal interactions in a stochastic dynamical system based on information geometry. In the proposed framework, the degree of interactions is quantified by the divergence…

Neurons and Cognition · Quantitative Biology 2016-12-08 Masafumi Oizumi , Naotsugu Tsuchiya , Shun-ichi Amari

The mechanism that maintains atrial fibrillation (AF) remains elusive. One approach to understanding and controlling the mechanism ("AF driver") is to quantify inter-scale information flow from macroscopic to microscopic behaviors of the…

Pattern Formation and Solitons · Physics 2018-08-01 Hiroshi Ashikaga , Ryan G. James

The constituents of a complex system exchange information to function properly. Their signalling dynamics often leads to the appearance of emergent phenomena, such as phase transitions and collective behaviors. While information exchange…

Physics and Society · Physics 2020-11-18 Arsham Ghavasieh , Carlo Nicolini , Manlio De Domenico

Measures of information transfer have become a popular approach to analyze interactions in complex systems such as the Earth or the human brain from measured time series. Recent work has focused on causal definitions of information transfer…

Methodology · Statistics 2016-03-21 Jakob Runge

Recent research is revealing how cognitive processes are supported by a complex interplay between the brain and the rest of the body, which can be investigated by the analysis of physiological features such as breathing rhythms, heart rate,…

Quantitative Methods · Quantitative Biology 2023-03-10 Fernando E. Rosas , Diego Candia-Rivera , Andrea I Luppi , Yike Guo , Pedro A. M. Mediano

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory…

Numerical Analysis · Mathematics 2022-08-12 Michele Bucelli , Alberto Zingaro , Pasquale Claudio Africa , Ivan Fumagalli , Luca Dede' , Alfio Quarteroni
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