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200 papers

Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact. Existing network alignments use…

Molecular Networks · Quantitative Biology 2009-10-08 Oleksii Kuchaiev , Tijana Milenkovic , Vesna Memisevic , Wayne Hayes , Natasa Przulj

Recent advances in machine learning have dramatically improved our ability to model language, vision, and other high-dimensional data, yet they continue to struggle with one of the most fundamental aspects of biological systems: movement.…

Artificial Intelligence · Computer Science 2025-07-04 Melanie Segado , Felipe Parodi , Jordan K. Matelsky , Michael L. Platt , Eva B. Dyer , Konrad P. Kording

Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

Neural and Evolutionary Computing · Computer Science 2020-05-05 Qiang Yu , Shenglan Li , Huajin Tang , Longbiao Wang , Jianwu Dang , Kay Chen Tan

Understanding large molecular networks consisting of entities such as genes, proteins or RNAs that interact in complex ways to drive the cellular machinery has been an active focus of systems biology. Computational approaches have played a…

Molecular Networks · Quantitative Biology 2013-04-23 Sriganesh Srihari , Mark A. Ragan

For real-world complex system constantly enduring perturbation, to achieve survival goal in changing yet unknown environments, the central problem is constantly adapting themself to external environments according to environmental feedback.…

Adaptation and Self-Organizing Systems · Physics 2024-10-31 Mingyang Bai , Daqing Li

We consider the information transmission problem in neurons and its possible implications for learning in neural networks. Our approach is based on recent developments in statistical physics and complexity science. Combining sensory…

Neurons and Cognition · Quantitative Biology 2025-09-30 Siddharth Kackar

Many of life's most fascinating phenomena emerge from interactions among many elements--many amino acids determine the structure of a single protein, many genes determine the fate of a cell, many neurons are involved in shaping our thoughts…

Quantitative Methods · Quantitative Biology 2011-11-28 Thierry Mora , William Bialek

We introduce bio-inspired artificial neural networks consisting of neurons that are additionally characterized by spatial positions. To simulate properties of biological systems we add the costs penalizing long connections and the proximity…

Neural and Evolutionary Computing · Computer Science 2019-10-08 Maciej Wołczyk , Jacek Tabor , Marek Śmieja , Szymon Maszke

Evolutionary search is well suited for large-scale biophysical brain modeling, where many parameters with nonlinear interactions and no tractable gradients need to be optimized. Standard evolutionary approaches achieve an excellent fit to…

Neural and Evolutionary Computing · Computer Science 2026-04-06 Hormoz Shahrzad , Niharika Gajawelli , Kaitlin Maile , Manish Saggar , Risto Miikkulainen

Nowadays, we have witnessed the great success of AI in various applications, including image classification, game playing, protein structure analysis, language translation, and content generation. Despite these powerful applications, there…

Neurons and Cognition · Quantitative Biology 2023-01-23 Luyao Chen , Zhiqiang Chen , Longsheng Jiang , Xiang Liu , Linlu Xu , Bo Zhang , Xiaolong Zou , Jinying Gao , Yu Zhu , Xizi Gong , Shan Yu , Sen Song , Liangyi Chen , Fang Fang , Si Wu , Jia Liu

The brain constantly turns large flows of sensory information into selective representations of the environment. It, therefore, needs to learn to process those sensory inputs that are most relevant for behaviour. It is not well understood…

Neurons and Cognition · Quantitative Biology 2023-01-10 Pouya Baniasadi

Time perception - how humans and animals perceive the passage of time - forms the basis for important cognitive skills such as decision-making, planning, and communication. In this work, we propose a framework for examining the mechanisms…

Systems and Control · Electrical Eng. & Systems 2023-11-08 Inês Lourenço , Robert Mattila , Rodrigo Ventura , Bo Wahlberg

The payload performance of conventional computing systems, from single processors to supercomputers, reached its limits the nature enables. Both the growing demand to cope with "big data" (based on, or assisted by, artificial intelligence)…

Emerging Technologies · Computer Science 2020-09-30 János Végh , Ádám J. Berki

Biological neural networks operate in the presence of task disruptions as they guide organisms toward goals. A familiar stream of stimulus-response causations can be disrupted by subtask streams imposed by the environment. For example,…

Machine Learning · Computer Science 2022-07-15 Thomas E. Portegys

Neuronal circuits of the cerebral cortex are the structural basis of mammalian cognition. The same qualitative components and connectivity motifs are repeated across functionally specialized cortical areas and mammalian species, suggesting…

Neurons and Cognition · Quantitative Biology 2025-07-04 Arno Granier , Katharina A Wilmes , Mihai A Petrovici , Walter Senn

The brain can be considered as a system that dynamically optimizes the structure of anatomical connections based on the efficiency requirements of functional connectivity. To illustrate the power of this principle in organizing the…

Neurons and Cognition · Quantitative Biology 2024-02-07 Carlos Calvo Tapia , Valeriy A. Makarov Slizneva , Cees van Leeuwen

Living organisms are not just random collections of organic molecules. There is continuous information processing going on in the apparent bouncing around of molecules of life. Optimisation criteria in this information processing can be…

Quantum Physics · Physics 2007-05-23 Apoorva Patel

Memories are stored, retained, and recollected through complex, coupled processes operating on multiple timescales. To understand the computational principles behind these intricate networks of interactions we construct a broad class of…

Neurons and Cognition · Quantitative Biology 2015-07-29 Marcus K. Benna , Stefano Fusi

Despite the obvious advantage of simple life forms capable of fast replication, different levels of cognitive complexity have been achieved by living systems in terms of their potential to cope with environmental uncertainty. Against the…

Populations and Evolution · Quantitative Biology 2017-10-18 Luís F Seoane , Ricard Solé

We create a novel optimisation technique inspired by natural ecosystems, where the optimisation works at two levels: a first optimisation, migration of genes which are distributed in a peer-to-peer network, operating continuously in time;…

Neural and Evolutionary Computing · Computer Science 2012-11-26 Gerard Briscoe , Philippe De Wilde