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This study proposes a novel approach combining Multimodal Deep Learning with intrinsic eXplainable Artificial Intelligence techniques to predict pathological response in non-small cell lung cancer patients undergoing neoadjuvant therapy.…
Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…
Multimodal fusion has emerged as a promising paradigm for disease diagnosis and prognosis, integrating complementary information from heterogeneous data sources such as medical images, clinical records, and radiology reports. However,…
Lung cancer has a high rate of recurrence in early-stage patients. Predicting the post-surgical recurrence in lung cancer patients has traditionally been approached using single modality information of genomics or radiology images. We…
The rapid development of diagnostic technologies in healthcare is leading to higher requirements for physicians to handle and integrate the heterogeneous, yet complementary data that are produced during routine practice. For instance, the…
Prostate cancer is one of the leading causes of cancer-related death in men worldwide. Like many cancers, diagnosis involves expert integration of heterogeneous patient information such as imaging, clinical risk factors, and more. For this…
The early detection and nuanced subtype classification of non-small cell lung cancer (NSCLC), a predominant cause of cancer mortality worldwide, is a critical and complex issue. In this paper, we introduce an innovative integration of…
Survival outcome assessment is challenging and inherently associated with multiple clinical factors (e.g., imaging and genomics biomarkers) in cancer. Enabling multimodal analytics promises to reveal novel predictive patterns of patient…
Accurate classification of histological subtypes of non-small cell lung cancer (NSCLC) is essential in the era of precision medicine, yet current invasive techniques are not always feasible and may lead to clinical complications. This study…
Cancer prognosis and survival outcome predictions are crucial for therapeutic response estimation and for stratifying patients into various treatment groups. Medical domains concerned with cancer prognosis are abundant with multiple…
Accurate survival prediction in Non-Small Cell Lung Cancer (NSCLC) requires integrating clinical, radiological, and histopathological data. Multimodal Deep Learning (MDL) can improve precision prognosis, but small cohorts and missing…
The most common type of lung cancer, lung adenocarcinoma (LUAD), has been increasingly detected since the advent of low-dose computed tomography screening technology. In clinical practice, pre-invasive LUAD (Pre-IAs) should only require…
Major pathological response (pR) following neoadjuvant therapy is a clinically meaningful endpoint in non-small cell lung cancer, strongly associated with improved survival. However, accurate preoperative prediction of pR remains…
Multimodal medical imaging plays a pivotal role in clinical diagnosis and research, as it combines information from various imaging modalities to provide a more comprehensive understanding of the underlying pathology. Recently, deep…
Automatic radiology report generation can alleviate the workload for physicians and minimize regional disparities in medical resources, therefore becoming an important topic in the medical image analysis field. It is a challenging task, as…
The importance of radiomics features for predicting patient outcome is now well-established. Early study of prognostic features can lead to a more efficient treatment personalisation. For this reason new radiomics features obtained through…
Cancer has relational information residing at varying scales, modalities, and resolutions of the acquired data, such as radiology, pathology, genomics, proteomics, and clinical records. Integrating diverse data types can improve the…
Medical patient data is always multimodal. Images, text, age, gender, histopathological data are only few examples for different modalities in this context. Processing and integrating this multimodal data with deep learning based methods is…
Recent advancements in signal processing and machine learning coupled with developments of electronic medical record keeping in hospitals and the availability of extensive set of medical images through internal/external communication…
Accurate prognosis for an individual patient is a key component of precision oncology. Recent advances in machine learning have enabled the development of models using a wider range of data, including imaging. Radiomics aims to extract…