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DNA storage has emerged as a promising solution for large-scale and long-term data preservation. Among various error types, insertions are the most frequent errors occurring in DNA sequences, where the inserted symbol is often identical or…

Information Theory · Computer Science 2026-04-07 Hengfeng Liu , Chunming Tang , Cuiling Fan

In the current world due to the huge demand for storage, DNA-based storage solution sounds quite promising because of their longevity, low power consumption, and high capacity. However in real life storing data in the form of DNA is quite…

Information Theory · Computer Science 2024-04-09 Sanket Doshi , Mihir Gohel , Manish K. Gupta

The coverage depth problem in DNA data storage is about computing the expected number of reads needed to recover all encoded strands. Given a generator matrix of a linear code, this quantity equals the expected number of randomly drawn…

Information Theory · Computer Science 2026-03-09 Matteo Bertuzzo , Alberto Ravagnani , Eitan Yaakobi

Over the past years, the ever-growing trend on data storage demand, more specifically for "cold" data (rarely accessed data), has motivated research for alternative systems of data storage. Because of its biochemical characteristics,…

Image and Video Processing · Electrical Eng. & Systems 2023-06-23 Xavier Pic , Eva Gil San Antonio , Melpomeni Dimopoulou , Marc Antonini

As deep neural networks (DNNs) are increasingly used in safety-critical applications, there is a growing concern for their reliability. Even highly trained, high-performant networks are not 100% accurate. However, it is very difficult to…

Neural and Evolutionary Computing · Computer Science 2024-07-30 Eduard Pinconschi , Divya Gopinath , Rui Abreu , Corina S. Pasareanu

We present a finite blocklength performance bound for a DNA storage channel with insertions, deletions, and substitutions. The considered bound -- the dependency testing (DT) bound, introduced by Polyanskiy et al. in 2010 -- provides an…

Information Theory · Computer Science 2023-08-07 Issam Maarouf , Gianluigi Liva , Eirik Rosnes , Alexandre Graell i Amat

The synthesis of DNA strands remains the most costly part of the DNA storage system. Thus, to make DNA storage system more practical, the time and materials used in the synthesis process have to be optimized. We consider the most common…

Information Theory · Computer Science 2023-05-15 Johan Chrisnata , Han Mao Kiah , Van Long Phuoc Pham

Digital data explosion drives a demand for robust and reliable data storage medium. Development of better digital storage device to accumulate Zetta bytes (1 ZB = $10^{21}$ bytes ) of data that will be generated in near future is a big…

Information Theory · Computer Science 2015-05-20 Dixita Limbachiya , Manish K. Gupta

Most living systems rely on double-stranded DNA (dsDNA) to store their genetic information and perpetuate themselves. This biological information has been considered the main target of evolution. However, here we show that symmetries and…

Biomolecules · Quantitative Biology 2025-05-01 Piero Fariselli , Cristian Taccioli , Luca Pagani , Amos Maritan

Motivated by average-case trace reconstruction and coding for portable DNA-based storage systems, we initiate the study of \emph{coded trace reconstruction}, the design and analysis of high-rate efficiently encodable codes that can be…

Information Theory · Computer Science 2019-09-11 Mahdi Cheraghchi , Ryan Gabrys , Olgica Milenkovic , João Ribeiro

In the current era, DeoxyriboNucleic Acid (DNA) based data storage emerges as an intriguing approach, garnering substantial academic interest and investigation. This paper introduces a novel deep joint source-channel coding (DJSCC) scheme…

Emerging Technologies · Computer Science 2023-11-03 Wenfeng Wu , Luping Xiang , Qiang Liu , Kun Yang

While most current high-throughput DNA sequencing technologies generate short reads with low error rates, emerging sequencing technologies generate long reads with high error rates. A basic question of interest is the tradeoff between read…

Information Theory · Computer Science 2015-01-27 Ilan Shomorony , Thomas Courtade , David Tse

Distributed Hash Tables offer a resilient lookup service for unstable distributed environments. Resilient data storage, however, requires additional data replication and maintenance algorithms. These algorithms can have an impact on both…

Distributed, Parallel, and Cluster Computing · Computer Science 2007-05-23 Matthew Leslie

The two strands of a DNA molecule with a repetitive sequence can pair into many different basepairing patterns. For perfectly periodic sequences, early bulk experiments of Poerschke indicate the existence of a sliding process, permitting…

Biomolecules · Quantitative Biology 2007-05-23 Richard A. Neher , Ulrich Gerland

In the recent years, DNA has emerged as a potentially viable storage technology. DNA synthesis, which refers to the task of writing the data into DNA, is perhaps the most costly part of existing storage systems. Accordingly, this high cost…

Information Theory · Computer Science 2022-04-15 Ohad Elishco , Wasim Huleihel

Digital information can be encoded in the building-block sequence of macromolecules, such as RNA and single-stranded DNA. Methods of "writing" and "reading" macromolecular strands are currently available, but they are slow and expensive. In…

Emerging Technologies · Computer Science 2017-09-14 Pramod K. Khulbe , Raphael Gruener , Masud Mansuripur

Data distribution across different facilities offers benefits such as enhanced resource utilization, increased resilience through replication, and improved performance by processing data near its source. However, managing such data is…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-02 Dante D. Sanchez-Gallegos , J. L. Gonzalez-Compean , Maxime Gonthier , Valerie Hayot-Sasson , J. Gregory Pauloski , Haochen Pan , Kyle Chard , Jesus Carretero , Ian Foster

We investigate the fundamental limits of the recently proposed random access coverage depth problem for DNA data storage. Under this paradigm, it is assumed that the user information consists of $k$ information strands, which are encoded…

Information Theory · Computer Science 2025-09-25 Anina Gruica , Daniella Bar-Lev , Alberto Ravagnani , Eitan Yaakobi

Data storage systems are more reliable than their individual components. In order to build highly reliable systems out of less reliable parts, systems introduce redundancy. In replicated systems, objects are simply copied several times with…

Information Theory · Computer Science 2013-08-13 John Cook , Robert Primmer , Ab de Kwant

A number of methods have been proposed over the last decade for encoding information using deoxyribonucleic acid (DNA), giving rise to the emerging area of DNA data embedding. Since a DNA sequence is conceptually equivalent to a sequence of…

Information Theory · Computer Science 2014-10-09 Félix Balado