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The inherently low signal-to-noise ratio of NMR and MRI is now being addressed by hyperpolarization methods. For example, iridium-based catalysts that reversibly bind both parahydrogen and ligands in solution can hyperpolarize protons…

SABRE (Signal Amplification by Reversible Exchange) methods provide a simple, fast, and cost-effective method to hyperpolarize a wide variety of molecules in solution, and have been demonstrated with protons and, more recently, with…

Chemical Physics · Physics 2022-02-14 Xiaoqing Li , Jacob R. Lindale , Shannon L. Eriksson , Warren S. Warren

Signal Amplification By Reversible Exchange (SABRE) creates hyperpolarization (large spin magnetization) using a transition metal catalyst and parahydrogen, addressing the sensitivity limitations of magnetic resonance. SABRE and its…

Chemical Physics · Physics 2021-07-13 Shannon L. Eriksson , Jacob R. Lindale , Xiaoqing Li , Warren S. Warren

Hyperpolarisation using Signal Amplification By Reversible Exchange (SABRE) is a convenient method for high repeatability studies. The core of this technique is polarisation transfer to the target substrate during an on-going chemical…

Parahydrogen (pH2) is a convenient and cost efficient source for magnetic resonance signal enhancement. Transient interaction of pH2 with a metal organic complex in a signal amplification by reversible exchange (SABRE) experiment enabled…

Hyperpolarization approaches in magnetic resonance overcome the sensitivity limitations imposed by thermal magnetization and play an important role in a very wide range of modern applications. One of the newer strategies, variants of what…

Chemical Physics · Physics 2025-11-10 Loren L. Smith , Warren S. Warren

Hyperpolarization methods in magnetic resonance overcome sensitivity limitations, especially for low-{\gamma} nuclei such as 13C and 15N. Signal Amplification By Reversible Exchange (SABRE) and extended SABRE (X-SABRE) are efficient and…

Chemical Physics · Physics 2022-04-06 Jacob R. Lindale , Shannon L. Eriksson , Warren S. Warren

A theoretical approach is proposed for quantitative modeling of SABRE (Signal Amplification By Reversible Exchange) experiments performed at a high magnetic field of an NMR spectrometer. SABRE is a method, which exploits the spin order of…

Chemical Physics · Physics 2019-05-01 Stephan Knecht , Konstantin L. Ivanov

SABRE (Signal Amplification By Reversible Exchange) has become a widely used method for hyper-polarizing nuclear spins, thereby enhancing their Nuclear Magnetic Resonance (NMR) signals by orders of magnitude. In SABRE experiments,…

Chemical Physics · Physics 2020-12-02 Stephan Knecht , Danila A. Barskiy , Gerd Buntkowsky , Konstantin L. Ivanov

Signal amplification by reversible exchange (SABRE) is a nuclear spin hyperpolarization technique in which the transient interaction of parahydrogen (pH2) and a target substrate with an iridium complex leads to polarization transfer to the…

SABRE (Signal Amplification By Reversible Exchange) is a technique for enhancement of NMR (Nuclear Magnetic Resonance) signals, which utilizes parahydrogen (pH2, the H2 molecule in its nuclear spin state) as a source of non-thermal spin…

Development of the methods to exploit nuclear hyperpolarization and search for molecules whose nuclear spins can be efficiently hyperpolarized is an active area in nuclear magnetic resonance. Of particular interest are those molecules that…

Spin-polarized solid targets have underpinned many recent key advances in nuclear and particle physics, yet traditional methods to produce them face significant limitations due to the high cost and demanding cryogenic and magnetic field…

Nuclear spin hyperpolarization enables real-time observation of metabolism and intermolecular interactions in vivo. 1-13C-Pyruvate is the leading hyperpolarized tracer currently under evaluation in several clinical trials as a promising…

We show that a combination of a half-cycle pulse and a short nonresonant laser pulse produces a strongly enhanced postpulse orientation. Robust transients that display both efficient and long-lived orientation are obtained. The mechanism is…

Quantum Physics · Physics 2007-05-23 D. Daems , S. Guérin , D. Sugny , H. R. Jauslin

Spin-polarized transport through a band-gap-matched ZnSe/Zn_{1-x}Mn_{x} Se/ZnSe/Zn_{1-x}Mn_{x}Se/ZnSe multilayer structure is investigated. The resonant transport is shown to occur at different energies for different spins owing to the…

Mesoscale and Nanoscale Physics · Physics 2009-11-13 Zhen-Gang Zhu , Gang Su

The serrodyne principle enables shifting the frequency of an electromagnetic signal by applying a linear phase ramp in the time domain [1]. This phenomenon has been exploited to frequency-shift signals in the radiofrequency (RF), microwave…

Hyperpolarization of nuclear spins enhances nuclear magnetic resonance signals, which play a key role for imaging and spectroscopy in the natural and life sciences. This signal amplification unlocks previously inaccessible techniques, such…

The 5th generation (5G) new radio (NR) access technology and the beyond-5G future wireless communication require extremely high data rate and spectrum efficiency. Energy-efficient transmission/reception schemes are also regarded as an…

Signal Processing · Electrical Eng. & Systems 2024-04-04 Paul Oh , Sean Kwon

EXSY, TOCSY and NOESY lie at the foundation of homonuclear NMR experiments in organic and pharmaceutical chemistry, as well as in structural biology. Limited magnetization transfer efficiency is an intrinsic downside of these methods,…

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