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The complex dynamics of gene expression in living cells can be well-approximated using Boolean networks. The average sensitivity is a natural measure of stability in these systems: values below one indicate typically stable dynamics…

Molecular Networks · Quantitative Biology 2018-10-03 Bryan C. Daniels , Hyunju Kim , Douglas Moore , Siyu Zhou , Harrison Smith , Bradley Karas , Stuart A. Kauffman , Sara I. Walker

We present a selective review of statistical modeling of dynamic networks. We focus on models with latent variables, specifically, the latent space models and the latent class models (or stochastic blockmodels), which investigate both the…

Methodology · Statistics 2018-05-31 Bomin Kim , Kevin Lee , Lingzhou Xue , Xiaoyue Niu

Boolean networks is a well-established formalism for modelling biological systems. A vital challenge for analysing a Boolean network is to identify all the attractors. This becomes more challenging for large asynchronous Boolean networks,…

Molecular Networks · Quantitative Biology 2017-06-14 Andrzej Mizera , Jun Pang , Hongyang Qu , Qixia Yuan

Random Boolean Network has been used to find out regulation patterns of genes in organism. his approach is very interesting to use in a game such as N Person PD. Here we assume that action is influenced by input in the form of choices of…

Disordered Systems and Neural Networks · Physics 2007-05-23 Hokky Situngkir , Deni Khanafiah

Symmetries are ubiquitous in network systems and have profound impacts on the observable dynamics. At the most fundamental level, many synchronization patterns are induced by underlying network symmetry, and a high degree of symmetry is…

Adaptation and Self-Organizing Systems · Physics 2019-02-18 Joseph D. Hart , Yuanzhao Zhang , Rajarshi Roy , Adilson E. Motter

Training large machine learning (ML) models with many variables or parameters can take a long time if one employs sequential procedures even with stochastic updates. A natural solution is to turn to distributed computing on a cluster;…

Machine Learning · Statistics 2013-12-31 Seunghak Lee , Jin Kyu Kim , Qirong Ho , Garth A. Gibson , Eric P. Xing

We investigate the propagation of perturbations in Boolean networks by evaluating the Derrida plot and modifications of it. We show that even small Random Boolean Networks agree well with the predictions of the annealed approximation, but…

Statistical Mechanics · Physics 2009-05-06 Christoph Fretter , Agnes Szejka , Barbara Drossel

Asynchronous Boolean networks are a type of discrete dynamical system in which each variable can take one of two states, and a single variable state is updated in each time step according to pre-selected rules. Boolean networks are popular…

Molecular Networks · Quantitative Biology 2024-10-08 Samuel Pastva , Kyu Hyong Park , Ondrej Huvar , Jordan C Rozum , Reka Albert

We develop a model in which interactions between nodes of a dynamic network are counted by non homogeneous Poisson processes. In a block modelling perspective, nodes belong to hidden clusters (whose number is unknown) and the intensity…

Machine Learning · Statistics 2017-07-11 Marco Corneli , Pierre Latouche , Fabrice Rossi

This paper presents a unified framework for analyzing the input-output behavior of discrete time complex networks viewed as open systems. Importantly, we focus on systems that are inherently modeled in discrete time-such as opinion…

Physics and Society · Physics 2025-11-25 Amirhossein Nazerian , MAlbor Asllani , Melvyn Tyloo , Francesco Sorrentino

Progress in cell type reprogramming has revived the interest in Waddington's concept of the epigenetic landscape. Recently researchers developed the quasi-potential theory to represent the Waddington's landscape. The Quasi-potential U(x),…

Molecular Networks · Quantitative Biology 2016-05-09 Joseph Xu Zhou , Areejit Samal , Aymeric Fouquier d'Hèrouël , Nathan D. Price , Sui Huang

Finite dynamical systems (e.g. Boolean networks and logical models) have been used in modeling biological systems to focus attention on the qualitative features of the system, such as the wiring diagram. Since the analysis of such systems…

Molecular Networks · Quantitative Biology 2012-11-27 Alan Veliz-Cuba , Kristina Buschur , Rose Hamershock , Ariel Kniss , Esther Wolff , Reinhard Laubenbacher

We propose the use of Deterministic Generalized Asynchronous Random Boolean Networks [Gershenson, 2002] as models of contextual deterministic discrete dynamical systems. We show that changes in the context have drastic effects on the global…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Carlos Gershenson , Jan Broekaert , Diederik Aerts

The control of biological systems presents interesting applications such as cell reprogramming or drug target identification. A common type of control strategy consists in a set of interventions that, by fixing the values of some variables,…

Molecular Networks · Quantitative Biology 2021-12-21 Laura Cifuentes Fontanals , Elisa Tonello , Heike Siebert

We study the stable attractors of a class of continuous dynamical systems that may be idealized as networks of Boolean elements, with the goal of determining which Boolean attractors, if any, are good approximations of the attractors of…

Molecular Networks · Quantitative Biology 2009-11-13 Johannes Norrell , Björn Samuelsson , Joshua E. S. Socolar

The goal of this tutorial is to promote interest in the study of random Boolean networks (RBNs). These can be very interesting models, since one does not have to assume any functionality or particular connectivity of the networks to study…

Adaptation and Self-Organizing Systems · Physics 2009-09-29 Carlos Gershenson

Network systems are one of the most active research areas in the engineering community as they feature a paradigm shift from centralized to distributed control and computation. When dealing with network systems, a fundamental challenge is…

Systems and Control · Computer Science 2018-02-26 D. Senejohnny , S. Sundaram , C. De Persis , P. Tesi

In this work we investigate time varying networks with complex dynamics at the nodes. We consider two scenarios of network change in an interval of time: first, we have the case where each link can change with probability pt, i.e. the…

Adaptation and Self-Organizing Systems · Physics 2014-04-14 Ankit Kumar , Vidit Agrawal , Sudeshna Sinha

This paper addresses the problem of finding cycles in the state transition graphs of synchronous Boolean networks. Synchronous Boolean networks are a class of deterministic finite state machines which are used for the modeling of gene…

Molecular Networks · Quantitative Biology 2009-01-29 Elena Dubrova , Maxim Teslenko

In a complex system, the interactions between individual agents often lead to emergent collective behavior like spontaneous synchronization, swarming, and pattern formation. The topology of the network of interactions can have a dramatic…

Adaptation and Self-Organizing Systems · Physics 2022-07-25 Mark J Panaggio , Maria-Veronica Ciocanel , Lauren Lazarus , Chad M Topaz , Bin Xu