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This paper addresses the following general scenario: A scientist wishes to perform a battery of experiments, each generating a sequential stream of data, to investigate some phenomenon. The scientist would like to control the overall error…

Methodology · Statistics 2014-05-12 Jay Bartroff , Jinlin Song

Verifying that a statistically significant result is scientifically meaningful is not only good scientific practice, it is a natural way to control the Type I error rate. Here we introduce a novel extension of the p-value - a…

Methodology · Statistics 2018-07-04 Jeffrey D. Blume , Lucy DAgostino McGowan , William D. Dupont , Robert A. Greevy

Many statistical methods have been proposed for variable selection in the past century, but few balance inference and prediction tasks well. Here we report on a novel variable selection approach called Penalized regression with…

Methodology · Statistics 2021-06-16 Yi Zuo , Thomas G. Stewart , Jeffrey D. Blume

Variable selection has become a pivotal choice in data analyses that impacts subsequent inference and prediction. In linear models, variable selection using Second-Generation P-Values (SGPV) has been shown to be as good as any other…

Methodology · Statistics 2021-09-22 Yi Zuo , Thomas G. Stewart , Jeffrey D. Blume

Post-approval safety surveillance of medical products using observational healthcare data can help identify safety issues beyond those found in pre-approval trials. When testing sequentially as data accrue, maximum sequential probability…

Methodology · Statistics 2022-07-07 Martijn J. Schuemie , Fan Bu , Akihiko Nishimura , Marc A. Suchard

Prescriptive Process Monitoring (PresPM) recommends interventions during business processes to optimize key performance indicators (KPIs). In realistic settings, interventions are rarely isolated: organizations need to align sequences of…

Machine Learning · Computer Science 2026-01-12 Jakob De Moor , Hans Weytjens , Johannes De Smedt , Jochen De Weerdt

The $\gamma$-FDP and $k$-FWER multiple testing error metrics, which are tail probabilities of the respective error statistics, have become popular recently as less-stringent alternatives to the FDR and FWER. We propose general and flexible…

Methodology · Statistics 2016-12-20 Jay Bartroff

This paper investigates sequential change-point detection in reconfigurable sensor networks. In this problem, data from multiple sensors are observed sequentially. Each sensor can have a unique change point, and the data distribution…

Methodology · Statistics 2025-04-10 Seungwon Lee , Yunxiao Chen , Xiaoou Li

Clinical trials are complex and usually involve multiple objectives such as controlling type I error rate, increasing power to detect treatment difference, assigning more patients to better treatment, and more. In literature, both…

Statistics Theory · Mathematics 2010-10-20 Hongjian Zhu , Feifang Hu

This paper studies sequential methods for recovery of sparse signals in high dimensions. When compared to fixed sample size procedures, in the sparse setting, sequential methods can result in a large reduction in the number of samples…

Information Theory · Computer Science 2014-10-07 Matthew L. Malloy , Robert Nowak

In many Phase II statistical process control (SPC) problems, the main concern is not whether a monitored process has ever changed, but whether it is currently operating at an acceptable level. This distinction is especially important when…

Computation · Statistics 2026-05-06 Gordon J. Ross

Simultaneous statistical inference has been a cornerstone in the statistics methodology literature because of its fundamental theory and paramount applications. The mainstream multiple testing literature has traditionally considered two…

Statistics Theory · Mathematics 2025-03-21 Monitirtha Dey , Subir Kumar Bhandari

This paper shows that sequential statistical analysis techniques can be generalised to the problem of selecting between alternative forecasting methods using scoring rules. A return to basic principles is necessary in order to show that…

Statistics Theory · Mathematics 2025-05-15 David T. Frazier , Donald S. Poskitt

Sequential monitoring in clinical trials is often employed to allow for early stopping and other interim decisions, while maintaining the type I error rate. However, sequential monitoring is typically described only in the context of a…

Statistics Theory · Mathematics 2012-05-29 Victoria Plamadeala , William F. Rosenberger

We develop a monitoring procedure to detect changes in a large approximate factor model. Letting $r$ be the number of common factors, we base our statistics on the fact that the $\left( r+1\right) $-th eigenvalue of the sample covariance…

Methodology · Statistics 2022-02-03 Matteo Barigozzi , Lorenzo Trapani

Selecting the top-$m$ variables with the $m$ largest population parameters from a larger set of candidates is a fundamental problem in statistics. In this paper, we propose a novel methodology called Sequential Correct Screening (SCS),…

Methodology · Statistics 2025-08-21 Masaki Toyoda , Yoshimasa Uematsu

Post-market safety surveillance is an integral part of mass vaccination programs. Typically relying on sequential analysis of real-world health data as they accrue, safety surveillance is challenged by the difficulty of sequential multiple…

This paper describes a methodology for detecting anomalies from sequentially observed and potentially noisy data. The proposed approach consists of two main elements: (1) {\em filtering}, or assigning a belief or likelihood to each…

Machine Learning · Computer Science 2016-11-17 Maxim Raginsky , Rebecca Willett , Corinne Horn , Jorge Silva , Roummel Marcia

Change point detection in high dimensional data has found considerable interest in recent years. Most of the literature either designs methodology for a retrospective analysis, where the whole sample is already available when the…

Statistics Theory · Mathematics 2020-12-16 Josua Gösmann , Christina Stoehr , Johannes Heiny , Holger Dette

This work considers the problem of detecting signals from multiple sequentially observed data streams, where only one stream can be observed at every time instant. The goal is to detect signals as quickly as possible while controlling the…

Methodology · Statistics 2026-04-07 Yiming Xing , Georgios Fellouris
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