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Structure-Based molecule optimization (SBMO) aims to optimize molecules with both continuous coordinates and discrete types against protein targets. A promising direction is to exert gradient guidance on generative models given its…

Biomolecules · Quantitative Biology 2025-06-06 Keyue Qiu , Yuxuan Song , Jie Yu , Hongbo Ma , Ziyao Cao , Zhilong Zhang , Yushuai Wu , Mingyue Zheng , Hao Zhou , Wei-Ying Ma

Multi-Objective Bi-Level Optimization (MOBLO) addresses nested multi-objective optimization problems common in a range of applications. However, its multi-objective and hierarchical bilevel nature makes it notably complex. Gradient-based…

Optimization and Control · Mathematics 2024-06-11 Xinmin Yang , Wei Yao , Haian Yin , Shangzhi Zeng , Jin Zhang

Stochastic gradient descent method and its variants constitute the core optimization algorithms that achieve good convergence rates for solving machine learning problems. These rates are obtained especially when these algorithms are…

Machine Learning · Computer Science 2024-03-14 S. Ilker Birbil , Ozgur Martin , Gonenc Onay , Figen Oztoprak

The stochastic subgradient method is a widely-used algorithm for solving large-scale optimization problems arising in machine learning. Often these problems are neither smooth nor convex. Recently, Davis et al. [1-2] characterized the…

Optimization and Control · Mathematics 2021-02-25 Shixiang Chen , Alfredo Garcia , Shahin Shahrampour

For the composite multi-objective optimization problem composed of two nonsmooth terms, a smoothing method is used to overcome the nonsmoothness of the objective function, making the objective function contain at most one nonsmooth term.…

Optimization and Control · Mathematics 2025-03-18 Huang Chengzhi

In this work we are interested in stochastic particle methods for multi-objective optimization. The problem is formulated using parametrized, single-objective sub-problems which are solved simultaneously. To this end a consensus based…

Optimization and Control · Mathematics 2022-08-03 Giacomo Borghi , Michael Herty , Lorenzo Pareschi

Black box discrete optimization (BBDO) appears in wide range of engineering tasks. Evolutionary or other BBDO approaches have been applied, aiming at automating necessary tuning of system parameters, such as hyper parameter tuning of…

Machine Learning · Computer Science 2018-09-19 Kouhei Nishida , Hernan Aguirre , Shota Saito , Shinichi Shirakawa , Youhei Akimoto

Real-world multiobjective optimization problems usually involve conflicting objectives that change over time, which requires the optimization algorithms to quickly track the Pareto optimal front (POF) when the environment changes. In recent…

Neural and Evolutionary Computing · Computer Science 2021-02-25 Dejun Xu , Min Jiang , Weizhen Hu , Shaozi Li , Renhu Pan , Gary G. Yen

Bregman parallel direction method of multipliers (BPDMM) efficiently solves distributed optimization over a network, which arises in a wide spectrum of collaborative multi-agent learning applications. In this paper, we generalize BPDMM to…

Optimization and Control · Mathematics 2019-03-05 Yue Yu , Behçet Açıkmeşe

We leverage multilevel Monte Carlo (MLMC) to improve the performance of multi-step look-ahead Bayesian optimization (BO) methods that involve nested expectations and maximizations. Often these expectations must be computed by Monte Carlo…

We consider a variable metric linesearch based proximal gradient method for the minimization of the sum of a smooth, possibly nonconvex function plus a convex, possibly nonsmooth term. We prove convergence of this iterative algorithm to a…

Numerical Analysis · Mathematics 2017-04-11 Silvia Bonettini , Ignace Loris , Federica Porta , Marco Prato , Simone Rebegoldi

The linearized Bregman iterations (LBreI) and its variants are powerful tools for finding sparse or low-rank solutions to underdetermined linear systems. In this study, we propose a cut-and-project perspective for the linearized Bregman…

Optimization and Control · Mathematics 2024-04-16 Yu-Hong Dai , Kangkang Deng , Hui Zhang

We introduce and analyze a fast iterative method based on sequential Bregman projections for nonlinear inverse problems in Banach spaces. The key idea, in contrast to the standard Landweber method, is to use multiple search directions per…

Numerical Analysis · Mathematics 2018-08-01 Anne Wald

We propose an Adagrad-like algorithm for multi-objective unconstrained optimization that relies on the computation of a common descent direction only. Unlike classical local algorithms for multi-objective optimization, our approach does not…

Optimization and Control · Mathematics 2026-02-06 Marianna De Santis , Gabriele Eichfelder , Margherita Porcelli

This study presents a novel Equiangular Direction Method (EDM) to solve a multi-objective optimization problem. We consider optimization problems, where multiple differentiable losses have to be minimized. The presented method computes…

Optimization and Control · Mathematics 2020-07-15 Alexandr Katrutsa , Daniil Merkulov , Nurislam Tursynbek , Ivan Oseledets

Multimodality is one of the biggest difficulties for optimization as local optima are often preventing algorithms from making progress. This does not only challenge local strategies that can get stuck. It also hinders meta-heuristics like…

Neural and Evolutionary Computing · Computer Science 2020-10-05 Vera Steinhoff , Pascal Kerschke , Pelin Aspar , Heike Trautmann , Christian Grimme

We present PESMO, a Bayesian method for identifying the Pareto set of multi-objective optimization problems, when the functions are expensive to evaluate. The central idea of PESMO is to choose evaluation points so as to maximally reduce…

Machine Learning · Statistics 2016-02-23 Daniel Hernández-Lobato , José Miguel Hernández-Lobato , Amar Shah , Ryan P. Adams

Constrained competitive optimization involves multiple agents trying to minimize conflicting objectives, subject to constraints. This is a highly expressive modeling language that subsumes most of modern machine learning. In this work we…

Optimization and Control · Mathematics 2020-06-19 Florian Schäfer , Anima Anandkumar , Houman Owhadi

Bilevel optimization (BO) has recently gained prominence in many machine learning applications due to its ability to capture the nested structure inherent in these problems. Recently, many hypergradient methods have been proposed as…

Optimization and Control · Mathematics 2024-09-04 Wanli Shi , Yi Chang , Bin Gu

Maximum mean discrepancy (MMD) has been widely employed to measure the distance between probability distributions. In this paper, we propose using MMD to solve continuous multi-objective optimization problems (MOPs). For solving MOPs, a…

Machine Learning · Computer Science 2025-05-21 Hao Wang , Chenyu Shi , Angel E. Rodriguez-Fernandez , Oliver Schütze
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