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Digital pathology is one of the most significant developments in modern medicine. Pathological examinations are the gold standard of medical protocols and play a fundamental role in diagnosis. Recently, with the advent of digital scanners,…

Image and Video Processing · Electrical Eng. & Systems 2021-12-09 Mahdi Arab Loodaricheh , Nader Karimi , Shadrokh Samavi

Histology imaging is an essential diagnosis method to finalize the grade and stage of cancer of different tissues, especially for breast cancer diagnosis. Specialists often disagree on the final diagnosis on biopsy tissue due to the complex…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Yongxiang Huang , Albert Chi-shing Chung

In practice, many medical datasets have an underlying taxonomy defined over the disease label space. However, existing classification algorithms for medical diagnoses often assume semantically independent labels. In this study, we aim to…

Computer Vision and Pattern Recognition · Computer Science 2022-09-14 Zhen Yu , Toan Nguyen , Yaniv Gal , Lie Ju , Shekhar S. Chandra , Lei Zhang , Paul Bonnington , Victoria Mar , Zhiyong Wang , Zongyuan Ge

Motivation: Human genomic datasets often contain sensitive information that limits use and sharing of the data. In particular, simple anonymisation strategies fail to provide sufficient level of protection for genomic data, because the data…

Quantitative Methods · Quantitative Biology 2019-08-27 Teppo Niinimäki , Mikko Heikkilä , Antti Honkela , Samuel Kaski

We address the problem of scene classification from optical remote sensing (RS) images based on the paradigm of hierarchical metric learning. Ideally, supervised metric learning strategies learn a projection from a set of training data…

Computer Vision and Pattern Recognition · Computer Science 2018-08-03 Akashdeep Goel , Biplab Banerjee , Aleksandra Pizurica

Dataset distillation seeks to synthesize a compact distilled dataset, enabling models trained on it to achieve performance comparable to models trained on the full dataset. Recent methods for large-scale datasets focus on matching global…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Xiao Cui , Yulei Qin , Wengang Zhou , Hongsheng Li , Houqiang Li

Hierarchical classification aims to sort the object into a hierarchical structure of categories. For example, a bird can be categorized according to a three-level hierarchy of order, family, and species. Existing methods commonly address…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Renzhen Wang , De cai , Kaiwen Xiao , Xixi Jia , Xiao Han , Deyu Meng

Predicting spatial gene expression from H&E histology offers a scalable and clinically accessible alternative to sequencing, but realizing clinical impact requires models that generalize across cancer types and capture biologically coherent…

Machine Learning · Computer Science 2026-02-10 Susu Hu , Qinghe Zeng , Nithya Bhasker , Jakob Nikolas Kather , Stefanie Speidel

Histopathological images provide rich information for disease diagnosis. Large numbers of histopathological images have been digitized into high resolution whole slide images, opening opportunities in developing computational image analysis…

Image and Video Processing · Electrical Eng. & Systems 2020-11-06 Jiayun Li , Wenyuan Li , Anthony Sisk , Huihui Ye , W. Dean Wallace , William Speier , Corey W. Arnold

The self-supervised ultrasound (US) video model pretraining can use a small amount of labeled data to achieve one of the most promising results on US diagnosis. However, it does not take full advantage of multi-level knowledge for learning…

Computer Vision and Pattern Recognition · Computer Science 2022-10-14 Chunhui Zhang , Yixiong Chen , Li Liu , Qiong Liu , Xi Zhou

This project aims to break down large pathology images into small tiles and then cluster those tiles into distinct groups without the knowledge of true labels, our analysis shows how difficult certain aspects of clustering tumorous and…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Mostafa Ibrahim , Kevin Bryson

Hypothesis transfer learning (HTL) contrasts domain adaptation by allowing for a previous task leverage, named the source, into a new one, the target, without requiring access to the source data. Indeed, HTL relies only on a hypothesis…

Machine Learning · Statistics 2023-07-17 Anass Aghbalou , Guillaume Staerman

Deep learning has emerged as a prominent field in recent literature, showcasing the introduction of models that utilize transfer learning to achieve remarkable accuracies in the classification of brain tumor MRI images. However, the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Raza Imam , Mohammed Talha Alam

Histopathological imaging is vital for cancer research and clinical practice, with multiplexed Immunofluorescence (MxIF) and Hematoxylin and Eosin (H&E) providing complementary insights. However, aligning different stains at the cell level…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Jun Jiang , Raymond Moore , Brenna Novotny , Leo Liu , Zachary Fogarty , Ray Guo , Markovic Svetomir , Chen Wang

Medical image analysis faces significant challenges in data sharing due to privacy regulations and complex institutional protocols. Dataset distillation offers a solution to address these challenges by synthesizing compact datasets that…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Le Dong , Jinghao Bian , Jingyang Hou , Jingliang Hu , Yilei Shi , Weisheng Dong , Xiao Xiang Zhu , Lichao Mou

The current standard for detecting human epidermal growth factor receptor 2 (HER2) status in breast cancer patients relies on HER2 amplification, identified through fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC).…

Image and Video Processing · Electrical Eng. & Systems 2024-09-27 Ardhendu Sekhar , Vrinda Goel , Garima Jain , Abhijeet Patil , Ravi Kant Gupta , Tripti Bameta , Swapnil Rane , Amit Sethi

We propose a Deep learning-based weak label learning method for analyzing whole slide images (WSIs) of Hematoxylin and Eosin (H&E) stained tumor tissue not requiring pixel-level or tile-level annotations using Self-supervised pre-training…

Image and Video Processing · Electrical Eng. & Systems 2023-06-29 Yoni Schirris , Efstratios Gavves , Iris Nederlof , Hugo Mark Horlings , Jonas Teuwen

We consider Heterogeneous Transfer Learning (HTL) from a source to a new target domain for high-dimensional regression with differing feature sets. Most homogeneous TL methods assume that target and source domains share the same feature…

Machine Learning · Statistics 2025-12-02 Jae Ho Chang , Massimiliano Russo , Subhadeep Paul

Hematoxylin and Eosin (H&E) has been the gold standard in tissue analysis for decades, however, tissue specimens stained in different laboratories vary, often significantly, in appearance. This variation poses a challenge for both…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Umair Khan , Jouni Härkönen , Marjukka Friman , Leena Latonen , Teijo Kuopio , Pekka Ruusuvuori

Learning high-quality, self-supervised, visual representations is essential to advance the role of computer vision in biomedical microscopy and clinical medicine. Previous work has focused on self-supervised representation learning (SSL)…

Computer Vision and Pattern Recognition · Computer Science 2023-03-06 Cheng Jiang , Xinhai Hou , Akhil Kondepudi , Asadur Chowdury , Christian W. Freudiger , Daniel A. Orringer , Honglak Lee , Todd C. Hollon