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Alzheimer's disease is a progressive, debilitating neurodegenerative disease that affects 50 million people globally. Despite this substantial health burden, available treatments for the disease are limited and its fundamental causes remain…

Machine Learning · Computer Science 2024-04-02 Matthew West , Colin Magdamo , Lily Cheng , Yingnan He , Sudeshna Das

Artificial intelligence (AI) has demonstrated significant potential in transforming healthcare through the analysis and modeling of electronic health records (EHRs). However, the inherent heterogeneity, temporal irregularity, and…

Machine Learning · Computer Science 2025-07-18 Weijieying Ren , Jingxi Zhu , Zehao Liu , Tianxiang Zhao , Vasant Honavar

The electronic health record (EHR) provides an unprecedented opportunity to build actionable tools to support physicians at the point of care. In this paper, we investigate survival analysis in the context of EHR data. We introduce deep…

Machine Learning · Statistics 2016-09-20 Rajesh Ranganath , Adler Perotte , Noémie Elhadad , David Blei

Electronic Health Records (EHRs) aggregate diverse information at the patient level, holding a trajectory representative of the evolution of the patient health status throughout time. Although this information provides context and can be…

Machine Learning · Computer Science 2022-09-12 João Figueira Silva , Sérgio Matos

Electronic Health Records (EHR) can be represented as temporal sequences that record the events (medical visits) from patients. Neural temporal point process (NTPP) has achieved great success in modeling event sequences that occur in…

Machine Learning · Computer Science 2024-04-15 Bingqing Liu

Electronic Health Record (EHR) has emerged as a valuable source of data for translational research. To leverage EHR data for risk prediction and subsequently clinical decision support, clinical endpoints are often time to onset of a…

Methodology · Statistics 2023-11-07 Yang Wang , Qingning Zhou , Tianxi Cai , Xuan Wang

Current machine learning models aiming to predict sepsis from Electronic Health Records (EHR) do not account for the heterogeneity of the condition, despite its emerging importance in prognosis and treatment. This work demonstrates the…

Quantitative Methods · Quantitative Biology 2020-11-24 Zina Ibrahim , Honghan Wu , Ahmed Hamoud , Lukas Stappen , Richard Dobson , Andrea Agarossi

The presence of detailed clinical information in electronic health record (EHR) systems presents promising prospects for enhancing patient care through automated retrieval techniques. Nevertheless, it is widely acknowledged that accessing…

Information Retrieval · Computer Science 2024-09-13 Abderrahim Oussama Batouche , Eugen Czeizler , Miika Koskinen , Tuomas Mirtti , Antti Sakari Rannikko

Electronic Health Records have become popular sources of data for secondary research, but their use is hampered by the amount of effort it takes to overcome the sparsity, irregularity, and noise that they contain. Modern learning…

Applications · Statistics 2025-02-28 Jacek M. Bajor , Diego A. Mesa , Travis J. Osterman , Thomas A. Lasko

Sequential diagnosis prediction on the Electronic Health Record (EHR) has been proven crucial for predictive analytics in the medical domain. EHR data, sequential records of a patient's interactions with healthcare systems, has numerous…

Machine Learning · Computer Science 2021-09-08 Xueping Peng , Guodong Long , Tao Shen , Sen Wang , Jing Jiang

Electronic health records (EHRs) form an invaluable resource for training clinical decision support systems. To leverage the potential of such systems in high-risk applications, we need large, structured tabular datasets on which we can…

Artificial Intelligence · Computer Science 2025-11-24 Paloma Rabaey , Adrick Tench , Stefan Heytens , Thomas Demeester

Envelope model also known as multivariate regression model was proposed to solve the multiple response regression problems. It measures the linear association between predictors and multiple responses by using the minimal reducing subspace…

Methodology · Statistics 2018-05-07 Bochao Jia

Deep Learning based models are currently dominating most state-of-the-art solutions for disease prediction. Existing works employ RNNs along with multiple levels of attention mechanisms to provide interpretability. These deep learning…

Machine Learning · Statistics 2022-06-01 Subhadip Maji , Raghav Bali , Sree Harsha Ankem , Kishore V Ayyadevara

Automatic subphenotyping from electronic health records (EHRs)provides numerous opportunities to understand diseases with unique subgroups and enhance personalized medicine for patients. However, existing machine learning algorithms either…

Machine Learning · Computer Science 2024-10-18 Ruohan Wang , Zilong Wang , Ziyang Song , David Buckeridge , Yue Li

We propose a novel semiparametric model for the joint distribution of a continuous longitudinal outcome and the baseline covariates using an enriched Dirichlet process (EDP) prior. This joint model decomposes into a linear mixed model for…

Methodology · Statistics 2018-06-08 Bret Zeldow , James Flory , Alisa Stephens-Shields , Marsha Raebel , Jason Roy

Electronic health records (EHR's) are only a first step in capturing and utilizing health-related data - the problem is turning that data into useful information. Models produced via data mining and predictive analysis profile inherited…

Databases · Computer Science 2011-12-08 Casey Bennett , Thomas Doub

Many patients with advanced cancers undergo multiple lines of treatment. We develop methods for estimating quality-adjusted outcomes and cost-effectiveness of therapy sequences, informed by patient-level longitudinal data from Electronic…

Quantitative Methods · Quantitative Biology 2024-12-20 Elizabeth A. Handorf , J. Robert Beck , Daniel M. Geynisman

Modeling continuous-time physiological processes that manifest a patient's evolving clinical states is a key step in approaching many problems in healthcare. In this paper, we develop the Hidden Absorbing Semi-Markov Model (HASMM): a…

Artificial Intelligence · Computer Science 2016-12-28 Ahmed M. Alaa , Mihaela van der Schaar

In the healthcare sector, the application of deep learning technologies has revolutionized data analysis and disease forecasting. This is particularly evident in the field of diabetes, where the deep analysis of Electronic Health Records…

Machine Learning · Computer Science 2024-12-06 Huadong Pang , Li Zhou , Yiping Dong , Peiyuan Chen , Dian Gu , Tianyi Lyu , Hansong Zhang

Learning from longitudinal electronic health records is limited if it does not capture the temporal trajectories of the patient's state in a clinical setting. Graph models allow us to capture the hidden dependencies of the multivariate…

Machine Learning · Computer Science 2025-03-31 Munib Mesinovic , Soheila Molaei , Peter Watkinson , Tingting Zhu