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The stochastic motions of a diffusing particle contain information concerning the particle's interactions with binding partners and with its local environment. However, accurate determination of the underlying diffusive properties, beyond…

Biological Physics · Physics 2016-12-21 Peter K. Koo , Simon G. J. Mochrie

Proximal Policy Optimization (PPO) is a widely used reinforcement learning algorithm known for its stability and sample efficiency, but it often suffers from premature convergence due to limited exploration. In this paper, we propose POEM…

Neural and Evolutionary Computing · Computer Science 2026-01-22 Casimir Czworkowski , Stephen Hornish , Alhassan S. Yasin

This study explores the potential of small language model(SLM) ensembles to achieve accuracy comparable to proprietary large language models (LLMs). We propose Ensemble Bayesian Inference (EBI), a novel approach that applies Bayesian…

Computation and Language · Computer Science 2025-12-23 Haru-Tada Sato , Fuka Matsuzaki , Jun-ichiro Takahashi

Data-efficient image classification is a challenging task that aims to solve image classification using small training data. Neural network-based deep learning methods are effective for image classification, but they typically require…

Neural and Evolutionary Computing · Computer Science 2022-12-05 Ying Bi , Bing Xue , Mengjie Zhang

Ensemble technique and under-sampling technique are both effective tools used for imbalanced dataset classification problems. In this paper, a novel ensemble method combining the advantages of both ensemble learning for biasing classifiers…

Machine Learning · Computer Science 2025-02-05 Jinyan Li , Yaoyang Wu , Simon Fong , Antonio J. Tallón-Ballesteros , Xin-she Yang , Sabah Mohammed , Feng Wu

Evolutionary algorithms have been successfully applied to a variety of optimisation problems in stationary environments. However, many real world optimisation problems are set in dynamic environments where the success criteria shifts…

Neural and Evolutionary Computing · Computer Science 2016-10-11 Matthew Hughes

1. Understanding the mechanisms underlying biological systems, and ultimately, predicting their behaviours in a changing environment requires overcoming the gap between mathematical models and experimental or observational data.…

Quantitative Methods · Quantitative Biology 2017-04-19 Philipp H Boersch-Supan , Sadie J Ryan , Leah R Johnson

In recent years, the Edge Computing (EC) paradigm has emerged as an enabling factor for developing technologies like the Internet of Things (IoT) and 5G networks, bridging the gap between Cloud Computing services and end-users, supporting…

Machine Learning · Computer Science 2022-01-19 Guilherme Cassales , Heitor Gomes , Albert Bifet , Bernhard Pfahringer , Hermes Senger

On-policy reinforcement learning (RL) algorithms are widely used for their strong asymptotic performance and training stability, but they struggle to scale with larger batch sizes, as additional parallel environments yield redundant data…

Machine Learning · Computer Science 2025-11-13 Jianren Wang , Yifan Su , Abhinav Gupta , Deepak Pathak

We present an algebraic approach to evolutionary accumulation modelling (EvAM). EvAM is concerned with learning and predicting the order in which evolutionary features accumulate over time. Our approach is complementary to the more common…

Applications · Statistics 2026-04-29 Jessica Renz , Frederik Witt , Iain G. Johnston

In this paper, we develop the notion of evidence lower bound difference (ELBD), based on which an efficient score algorithm is presented to implement feature selection on latent variables of VAE and its variants. Further, we propose weak…

Machine Learning · Statistics 2022-10-11 Yiran Dong , Chuanhou Gao

One of the most promising approaches for complex technical systems analysis employs ensemble methods of classification. Ensemble methods enable to build a reliable decision rules for feature space classification in the presence of many…

Artificial Intelligence · Computer Science 2016-01-11 Alexei Zhukov , Victor Kurbatsky , Nikita Tomin , Denis Sidorov , Daniil Panasetsky , Aoife Foley

Although a number of studies have shown that natural and laboratory populations initially well-adapted to their environment can evolve rapidly when conditions suddenly change, the dynamics of rapid adaptation are not well understood. Here a…

Populations and Evolution · Quantitative Biology 2017-09-22 Kavita Jain , Wolfgang Stephan

Evolution strategies (ES), as a family of black-box optimization algorithms, recently emerge as a scalable alternative to reinforcement learning (RL) approaches such as Q-learning or policy gradient, and are much faster when many central…

Machine Learning · Computer Science 2022-04-01 Zhi Wang , Chunlin Chen , Daoyi Dong

Many complex diseases are known to be affected by the interactions between genetic variants and environmental exposures beyond the main genetic and environmental effects. Study of gene-environment (G$\times$E) interactions is important for…

Methodology · Statistics 2019-10-01 Jie Ren , Fei Zhou , Xiaoxi Li , Qi Chen , Hongmei Zhang , Shuangge Ma , Yu Jiang , Cen Wu

Evolutionary multi-objective algorithms have been widely shown to be successful when utilized for a variety of stochastic combinatorial optimization problems. Chance constrained optimization plays an important role in complex real-world…

Neural and Evolutionary Computing · Computer Science 2023-03-06 Kokila Perera , Aneta Neumann , Frank Neumann

In epidemiology, identifying subpopulations that are particularly vulnerable to exposures and those who may benefit differently from exposure-reducing interventions is essential. Factors such as age, gender-specific vulnerabilities, and…

Methodology · Statistics 2024-12-11 David McCoy , Wenxin Zhang , Alan Hubbard , Mark van der Laan , Alejandro Schuler

We consider the challenges that arise when fitting complex ecological models to 'large' data sets. In particular, we focus on random effect models which are commonly used to describe individual heterogeneity, often present in ecological…

Methodology · Statistics 2022-05-17 Ruth King , Blanca Sarzo , Víctor Elvira

The theory of evolution states that the diversity of species can be explained by descent with modification. Therefore, all living beings are related through a common ancestor. This evolutionary process must have left traces in our molecular…

Quantitative Methods · Quantitative Biology 2018-08-09 Patricio Maturana Russel

A methodology is introduced which uses three simple objective function features to predict effective control parameters for differential evolution. This is achieved using cluster analysis techniques to classify objective functions using…

Neural and Evolutionary Computing · Computer Science 2019-06-25 Sean P. Walton , M. Rowan Brown