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We present an algorithm for the stochastic simulation of gene expression and heterogeneous population dynamics. The algorithm combines an exact method to simulate molecular-level fluctuations in single cells and a constant-number Monte…

Computational Physics · Physics 2016-08-24 Daniel A. Charlebois , Jukka Intosalmi , Dawn Fraser , Mads Kaern

In NeuroEvolution, the topologies of artificial neural networks are optimized with evolutionary algorithms to solve tasks in data regression, data classification, or reinforcement learning. One downside of NeuroEvolution is the large amount…

Neural and Evolutionary Computing · Computer Science 2019-02-12 Jörg Stork , Martin Zaefferer , Thomas Bartz-Beielstein

Genetic fitness optimization using small populations or small population updates across generations generally suffers from randomly diverging evolutions. We propose a notion of highly probable fitness optimization through feasible…

Neural and Evolutionary Computing · Computer Science 2007-05-23 Paul Vitanyi

Imitation learning is a popular paradigm to teach robots new tasks, but collecting robot demonstrations through teleoperation or kinesthetic teaching is tedious and time-consuming. In contrast, directly demonstrating a task using our human…

Robotics · Computer Science 2026-02-16 Nick Heppert , Minh Quang Nguyen , Abhinav Valada

Gene gains and losses have shaped the gene repertoire of species since the universal last common ancestor to species today. Genes in extant species were gained at different historical times via de novo creation of new genes, duplication of…

Populations and Evolution · Quantitative Biology 2018-02-19 Haiming Tang , Paul Thomas , Haoran Xia

What is a population? This review considers how a population may be defined in terms of understanding the structure of the underlying genetics of the individuals involved. The main approach is to consider statistically identifiable groups…

Populations and Evolution · Quantitative Biology 2013-06-05 Daniel John Lawson

We introduce a population dynamics model, where individual genomes are represented by bit-strings. Selection is described by death probabilities which depend on these genomes, and new individuals continuously replace the ones that die,…

Statistical Mechanics · Physics 2009-11-10 P. M. C. de Oliveira , J. S. Sa' Martins , D. Stauffer , S. Moss de Oliveira

Incorporating specific knowledge into large language models via retrieval-augmented generation (RAG) is a widespread technique that fuels many of today's industry AI applications. A fundamental problem is to assess if the context retrieved…

Information Retrieval · Computer Science 2026-05-08 Florian Geissler , Francesco Carella , Laura Fieback , Jakob Spiegelberg

Parental origin effects play an important role in mammal development and disorder. Case-control mother-child pair genotype data can be used to detect parental origin effects and is often convenient to collect in practice. Most existing…

Methodology · Statistics 2022-08-11 Yuang Tian , Hong Zhang , Alexandre Bureau , Hagit Hochner , Jinbo Chen

Initial population plays an important role in heuristic algorithms such as GA as it help to decrease the time those algorithms need to achieve an acceptable result. Furthermore, it may influence the quality of the final answer given by…

Neural and Evolutionary Computing · Computer Science 2014-06-19 Erfan Khaji , Amin Satlikh Mohammadi

The probability of the survival of the population of individuals of both sexes of given mature age, procreation rate and structure stability has been searched in the numerical experiment. The populations with long period of reproduction and…

Condensed Matter · Physics 2007-05-23 Kazimierz Pater

We consider the problem of estimating the evolutionary history of a set of species (phylogeny or species tree) from several genes. It is known that the evolutionary history of individual genes (gene trees) might be topologically distinct…

Populations and Evolution · Quantitative Biology 2016-11-18 Gautam Dasarathy , Robert Nowak , Sebastien Roch

A phylogeny describes the evolutionary history of an evolving population. Evolutionary search algorithms can perfectly track the ancestry of candidate solutions, illuminating a population's trajectory through the search space. However,…

Neural and Evolutionary Computing · Computer Science 2024-02-05 Alexander Lalejini , Marcos Sanson , Jack Garbus , Matthew Andres Moreno , Emily Dolson

The influence of time-dependent fitnesses on the infinite population dynamics of simple genetic algorithms (without crossover) is analyzed. Based on general arguments, a schematic phase diagram is constructed that allows one to characterize…

Biological Physics · Physics 2007-05-23 Christopher Ronnewinkel , Claus O. Wilke , Thomas Martinetz

In both population genetics and forensic genetics it is important to know how haplotypes are distributed in a population. Simulation of population dynamics helps facilitating research on the distribution of haplotypes. In forensic genetics,…

Computation · Statistics 2012-10-08 Mikkel Meyer Andersen , Poul Svante Eriksen

An algorithm that learns from a set of examples should ideally be able to exploit the available resources of (a) abundant computing power and (b) domain-specific knowledge to improve its ability to generalize. Connectionist…

Artificial Intelligence · Computer Science 2008-02-03 D. W. Opitz , J. W. Shavlik

We introduce ResGen, an efficient Residual Vector Quantization (RVQ)-based generative model for high-fidelity generation with fast sampling. RVQ improves data fidelity by increasing the number of quantization steps, referred to as depth,…

Machine Learning · Computer Science 2025-06-03 Jaehyeon Kim , Taehong Moon , Keon Lee , Jaewoong Cho

Human populations have a complex history of introgression and of changing population size. Human genetic variation has been affected by both these processes, so that inference of past population size depends upon the pattern of gene flow…

Populations and Evolution · Quantitative Biology 2017-03-29 John Hawks

This paper examines the use of a hierarchical coevolutionary genetic algorithm under different partnering strategies. Cascading clusters of sub-populations are built from the bottom up, with higher-level sub-populations optimising larger…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin , Larry Bull

Sparse recovery is one of the most fundamental and well-studied inverse problems. Standard statistical formulations of the problem are provably solved by general convex programming techniques and more practical, fast (nearly-linear time)…

Data Structures and Algorithms · Computer Science 2022-03-09 Jonathan A. Kelner , Jerry Li , Allen Liu , Aaron Sidford , Kevin Tian