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Many contemporary generative models of molecules are variational auto-encoders of molecular graphs. One term in their training loss pertains to reconstructing the input, yet reconstruction capabilities of state-of-the-art models have not…

Machine Learning · Computer Science 2023-05-05 Hagen Muenkler , Hubert Misztela , Michal Pikusa , Marwin Segler , Nadine Schneider , Krzysztof Maziarz

Many vision-related tasks benefit from reasoning over multiple modalities to leverage complementary views of data in an attempt to learn robust embedding spaces. Most deep learning-based methods rely on a late fusion technique whereby…

Computer Vision and Pattern Recognition · Computer Science 2020-03-04 Austin Reiter , Menglin Jia , Pu Yang , Ser-Nam Lim

In biological research, fluorescence staining is a key technique to reveal the locations and morphology of subcellular structures. However, it is slow, expensive, and harmful to cells. In this paper, we model it as a deep learning task…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Donghao Zhou , Chunbin Gu , Junde Xu , Furui Liu , Qiong Wang , Guangyong Chen , Pheng-Ann Heng

Highly periodic structures are often said to convey the beauty of nature. However, most material properties are strongly influenced by the defects they contain. On the mesoscopic scale, molecular self-assembly exemplifies this interplay;…

We analyze linear independence of rank one tensors produced by tensor powers of randomly perturbed vectors. This enables efficient decomposition of sums of high-order tensors. Our analysis builds upon [BCMV14] but allows for a wider range…

Data Structures and Algorithms · Computer Science 2018-10-30 Nima Anari , Constantinos Daskalakis , Wolfgang Maass , Christos H. Papadimitriou , Amin Saberi , Santosh Vempala

Identification and verification of molecular properties such as side effects is one of the most important and time-consuming steps in the process of molecule synthesis. For example, failure to identify side effects before submission to…

Quantitative Methods · Quantitative Biology 2024-04-12 Collin Beaudoin , Koustubh Phalak , Swaroop Ghosh

We present the discriminative recurrent sparse auto-encoder model, comprising a recurrent encoder of rectified linear units, unrolled for a fixed number of iterations, and connected to two linear decoders that reconstruct the input and…

Machine Learning · Computer Science 2013-03-20 Jason Tyler Rolfe , Yann LeCun

Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for molecular property prediction, but these tasks are generally aimed at specific,…

Quantitative Methods · Quantitative Biology 2020-10-05 Samuel G. Finlayson , Matthew B. A. McDermott , Alex V. Pickering , Scott L. Lipnick , Isaac S. Kohane

Deep Learning models enjoy considerable success in Natural Language Processing. While deep architectures produce useful representations that lead to improvements in various tasks, they are often difficult to interpret. This makes the…

Computation and Language · Computer Science 2013-04-29 Christian Scheible , Hinrich Schuetze

Learning to solve sequential tasks with recurrent models requires the ability to memorize long sequences and to extract task-relevant features from them. In this paper, we study the memorization subtask from the point of view of the design…

Machine Learning · Computer Science 2020-02-03 Antonio Carta , Alessandro Sperduti , Davide Bacciu

We show that neural networks trained by evolutionary reinforcement learning can enact efficient molecular self-assembly protocols. Presented with molecular simulation trajectories, networks learn to change temperature and chemical potential…

Statistical Mechanics · Physics 2020-06-01 Stephen Whitelam , Isaac Tamblyn

Conformation-dependent design of polymer sequences can be considered as a tool to control macromolecular self-assembly. We consider the monomer unit sequences created via the modification of polymers in a homogeneous melt in accordance with…

Soft Condensed Matter · Physics 2021-07-07 Elena N. Govorun , Ruslan M. Shupanov , Sophia A. Pavlenko , Alexei R. Khokhlov

Molecular machine learning has gained popularity with the advancements of geometric deep learning. In parallel, retrieval-augmented generation has become a principled approach commonly used with language models. However, the optimal…

Machine Learning · Computer Science 2025-07-04 Runzhong Wang , Rui-Xi Wang , Mrunali Manjrekar , Connor W. Coley

Attribute reconstruction is used to predict node or edge features in the pre-training of graph neural networks. Given a large number of molecules, they learn to capture structural knowledge, which is transferable for various downstream…

Machine Learning · Computer Science 2025-01-27 Eric Inae , Gang Liu , Meng Jiang

Typical methods for supervised sequence modeling are built upon the recurrent neural networks to capture temporal dependencies. One potential limitation of these methods is that they only model explicitly information interactions between…

Computer Vision and Pattern Recognition · Computer Science 2019-08-27 Canmiao Fu , Wenjie Pei , Qiong Cao , Chaopeng Zhang , Yong Zhao , Xiaoyong Shen , Yu-Wing Tai

Rapid determination of molecular structures can greatly accelerate workflows across many chemical disciplines. However, elucidating structure using only one-dimensional (1D) NMR spectra, the most readily accessible data, remains an…

Chemical Physics · Physics 2024-08-16 Frank Hu , Michael S. Chen , Grant M. Rotskoff , Matthew W. Kanan , Thomas E. Markland

Designing composite materials as per the application requirements is fundamentally a challenging and time consuming task. Here we report the development of a deep neural network based computational framework capable of solving the forward…

Materials Science · Physics 2022-09-14 Ashank , Soumen Chakravarty , Pranshu Garg , Ankit Kumar , Manish Agrawal , Prabhat K. Agnihotri

Automatic generation of sequences has been a highly explored field in the last years. In particular, natural language processing and automatic music composition have gained importance due to the recent advances in machine learning and…

Sound · Computer Science 2020-12-03 Sebastian Garcia-Valencia , Alejandro Betancourt , Juan G. Lalinde-Pulido

Combining additive models and neural networks allows to broaden the scope of statistical regression and extend deep learning-based approaches by interpretable structured additive predictors at the same time. Existing attempts uniting the…

Machine Learning · Statistics 2022-07-12 David Rügamer , Chris Kolb , Nadja Klein

Unlike molecular crystals, soft self-assembled fibres, micelles, vesicles, etc., exhibit a certain order in the arrangement of their constitutive monomers, but also high structural dynamicity and variability. Defects and disordered local…

Soft Condensed Matter · Physics 2021-12-16 Andrea Gardin , Claudio Perego , Giovanni Doni , Giovanni Maria Pavan
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