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Magnetic resonance spectroscopy (MRS) is an established technique for studying tissue metabolism, particularly in central nervous system disorders. While powerful and versatile, MRS is often limited by challenges associated with data…

Quantitative Methods · Quantitative Biology 2024-08-29 Christopher J. Wu , Lawrence S. Kegeles , Jia Guo

Sparse Principal Component Analysis (sparse PCA) is a fundamental dimension-reduction tool that enhances interpretability in various high-dimensional settings. An important variant of sparse PCA studies the scenario when samples are…

Optimization and Control · Mathematics 2024-11-11 Yuqing He , Guanyi Wang , Yu Yang

Magnetic resonance microscopy images at cellular resolution (< 10 microns) are limited by diffusion. SNR and spatial resolution suffer from the dephasing of transverse magnetization caused by diffusion of spins in strong gradients. Such…

We examine the problem of selecting a small set of linear measurements for reconstructing high-dimensional signals. Well-established methods for optimizing such measurements include principal component analysis (PCA), independent component…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Ling-Qi Zhang , Zahra Kadkhodaie , Eero P. Simoncelli , David H. Brainard

Quantitative magnetization transfer (qMT) imaging provides myelin-sensitive biomarkers, such as the pool size ratio (PSR), which is valuable for multiple sclerosis (MS) assessment. However, qMT requires specialized 20-30 minute scans. We…

Image and Video Processing · Electrical Eng. & Systems 2025-11-27 Jiacheng Wang , Hao Li , Xing Yao , Ahmad Toubasi , Taegan Vinarsky , Caroline Gheen , Joy Derwenskus , Chaoyang Jin , Richard Dortch , Junzhong Xu , Francesca Bagnato , Ipek Oguz

We propose a regression model for non-central $\chi$ (NC-$\chi$) distributed functional magnetic resonance imaging (fMRI) and diffusion weighted imaging (DWI) data, with the heteroscedastic Rician regression model as a prominent special…

Applications · Statistics 2016-12-22 Bertil Wegmann , Anders Eklund , Mattias Villani

Advances in microscopy imaging enable researchers to visualize structures at the nanoscale level thereby unraveling intricate details of biological organization. However, challenges such as image noise, photobleaching of fluorophores, and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-19 Pamela Osuna-Vargas , Maren H. Wehrheim , Lucas Zinz , Johanna Rahm , Ashwin Balakrishnan , Alexandra Kaminer , Mike Heilemann , Matthias Kaschube

Principal Component Analysis (PCA) has been widely used for dimensionality reduction and feature extraction. Robust PCA (RPCA), under different robust distance metrics, such as l1-norm and l2, p-norm, can deal with noise or outliers to some…

Machine Learning · Computer Science 2021-06-29 Zhao Kang , Hongfei Liu , Jiangxin Li , Xiaofeng Zhu , Ling Tian

The average symbol error probability (SEP) of a phase-quantized single-input multiple-output system with M-ary phase-shift keying modulation and maximum ratio combining (MRC) is analyzed under correlated Rayleigh fading and additive white…

Signal Processing · Electrical Eng. & Systems 2026-04-30 Amila Ravinath , Bikshapathi Gouda , Italo Atzeni , Antti Tölli

Many applications, such as photon-limited imaging and genomics, involve large datasets with noisy entries from exponential family distributions. It is of interest to estimate the covariance structure and principal components of the…

Methodology · Statistics 2017-03-08 Lydia T. Liu , Edgar Dobriban , Amit Singer

Magnetic resonance imaging (MRI), especially functional MRI (fMRI) and diffusion MRI (dMRI), is essential for studying neurodegenerative diseases. However, missing modalities pose a major barrier to their clinical use. Although GAN- and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Xiongri Shen , Jiaqi Wang , Yi Zhong , Zhenxi Song , Leilei Zhao , Yichen Wei , Lingyan Liang , Shuqiang Wang , Baiying Lei , Demao Deng , Zhiguo Zhang

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a non-invasive way of imaging white matter tracts in the human brain. DW-MRIs are usually acquired using echo-planar imaging (EPI) with high gradient fields, which could introduce…

Image and Video Processing · Electrical Eng. & Systems 2023-04-04 Zhangxing Bian , Muhan Shao , Aaron Carass , Jerry L. Prince

Data from a multi-parametric MRI study of patients with possible early-stage prostate cancer was assessed with a view to creating an efficient clinical protocol. Based on a correlation analysis suggesting that diffusion-weighted imaging…

Medical Physics · Physics 2017-11-28 Ioannis Papadopoulos , Jonathan Phillips , Rhodri Evans , Neil Fenn , Sophie Schermer

Denoising Score Matching estimates the score of a noised version of a target distribution by minimizing a regression loss and is widely used to train the popular class of Denoising Diffusion Models. A well known limitation of Denoising…

Machine Learning · Computer Science 2024-02-14 Valentin De Bortoli , Michael Hutchinson , Peter Wirnsberger , Arnaud Doucet

Spherical deconvolution (SD) methods are widely used to estimate the intra-voxel white-matter fiber orientations from diffusion MRI data. However, while some of these methods assume a zero-mean Gaussian distribution for the underlying…

The problem of Poisson denoising appears in various imaging applications, such as low-light photography, medical imaging and microscopy. In cases of high SNR, several transformations exist so as to convert the Poisson noise into an additive…

Computer Vision and Pattern Recognition · Computer Science 2015-06-17 Raja Giryes , Michael Elad

Recently, convolutional neural networks (CNNs) and attention mechanisms have been widely used in image denoising and achieved satisfactory performance. However, the previous works mostly use a single head to receive the noisy image,…

Computer Vision and Pattern Recognition · Computer Science 2022-11-07 Jiahong Zhang , Meijun Qu , Ye Wang , Lihong Cao

Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased…

Image and Video Processing · Electrical Eng. & Systems 2023-02-07 Tiange Xiang , Mahmut Yurt , Ali B Syed , Kawin Setsompop , Akshay Chaudhari

When measurements fall below or above a detection threshold, the resulting data are missing not at random (MNAR), posing challenges for statistical analysis. For example, in longitudinal biomarker studies, observations may be subject to…

Methodology · Statistics 2025-10-21 Haiyan Liu , Jeanine Houwing-Duistermaat

Structural magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients. The formation of these lesions is a complex process involving inflammation, tissue damage, and tissue repair, all…

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