Related papers: Viscoelastic Cahn--Hilliard models for tumour grow…
We study the following Cauchy problem for the linear wave equation with both time-dependent friction and time-dependent viscoelastic damping: \begin{equation} \label{EqAbstract}\tag{$\ast$} \begin{cases} u_{tt}- \Delta u + b(t)u_t -…
In this paper, we study an optimal control problem for a macroscopic mechanical tumour model based on the phase field approach. The model couples a Cahn--Hilliard type equation to a system of linear elasticity and a reaction-diffusion…
We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…
We present a two-dimensional continuum model of tumor growth, which treats the tissue as a composition of six distinct fluid phases; their dynamics are governed by the equations of mass and momentum conservation. Our model divides the…
We propose a new numerical method to solve the Cahn-Hilliard equation coupled with non-linear wetting boundary conditions. We show that the method is mass-conservative and that the discrete solution satisfies a discrete energy law similar…
We develop a new four-phase tumor growth model with angiogenesis, derived from a diffuse-interface mixture model composed by a viable, a necrotic, a liquid and an angiogenetic component, coupled with two massless chemicals representing a…
We consider a (degenerate) cross-diffusion model of tumor growth structured by phenotypic trait. We prove the existence of weak solutions and the incompressible limit as the pressure becomes stiff extending methods recently introduced in…
We analyze a diffuse interface model that describes the dynamics of incompressible viscous two-phase flows, incorporating mechanisms such as chemotaxis, active transport, and long-range interactions of Oono's type. The evolution system…
In this work, we investigate a distributed optimal control problem for an extended phase field system of Cahn--Hilliard type which physical context is that of tumor growth dynamics. In a previous contribution, the author has already studied…
Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…
The thermodynamical model of visco-elastic deformable solids at finite strains is formulated in a fully Eulerian way in rates. Also effects of thermal expansion or buoyancy due to evolving mass density in a gravity field are covered. The…
We study an initial-boundary value problem (IBVP) for a coupled Cahn-Hilliard-Hele-Shaw system that models tumor growth. For large initial data with finite energy, we prove global (local resp.) existence, uniqueness, higher order spatial…
A distributed optimal control problem for a phase field system which physical context is that of tumor growth is discussed. The system we are going to take into account consists of a Cahn-Hilliard equation for the phase variable (relative…
We investigate a diffuse-interface model that describes the dynamics of incompressible two-phase viscous flows with surfactant. The resulting system of partial differential equations consists of a sixth-order Cahn-Hilliard equation for the…
In this paper, we study the optimal control of a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. Both the cases…
The simulation of growth processes within soft biological tissues is of utmost importance for many applications in the medical sector. Within this contribution we propose a new macroscopic approach fro modelling stress-driven volumetric…
We study a distributed optimal control problem for a nonisothermal Caginalp-type phase-field model that describes tumour growth under thermal therapy. The PDE system couples a possibly viscous Cahn-Hilliard equation, governing the evolution…
We consider an optimal control problem for a diffuse interface model of tumor growth. The state equations couples a Cahn-Hilliard equation and a reaction-diffusion equation, which models the growth of a tumor in the presence of a nutrient…
We study the large-data Cauchy problem for two dimensional Oldroyd model of incompressible viscoelastic fluids. We prove the global-in-time existence of the Leray-Hopf type weak solutions in the physical energy space. Our method relies on a…
Strong experimental evidence has indicated that tumor growth belongs to the molecular beam epitaxy universality class. This type of growth is characterized by the constraint of cell proliferation to the tumor border, and surface diffusion…