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PURPOSE: The popularity of germline genetic panel testing has led to a vast accumulation of variant-level data. Variant names are not always consistent across laboratories and not easily mappable to public variant databases such as ClinVar.…

In high-energy physics, with the search for ever smaller signals in ever larger data sets, it has become essential to extract a maximum of the available information from the data. Multivariate classification methods based on machine…

With the increase in the variety and quantity of malware, there is an urgent need to speed up the diagnosis and the analysis of malware. Extracting the malware family-related tokens from AV (Anti-Virus) labels, provided by online anti-virus…

Cryptography and Security · Computer Science 2022-08-31 Ligeng Chen , Zhongling He , Hao Wu , Yuhang Gong , Bing Mao

PubTator 3.0 (https://www.ncbi.nlm.nih.gov/research/pubtator3/) is a biomedical literature resource using state-of-the-art AI techniques to offer semantic and relation searches for key concepts like proteins, genetic variants, diseases, and…

Computation and Language · Computer Science 2024-01-23 Chih-Hsuan Wei , Alexis Allot , Po-Ting Lai , Robert Leaman , Shubo Tian , Ling Luo , Qiao Jin , Zhizheng Wang , Qingyu Chen , Zhiyong Lu

A comprehensive analysis of viral mutations is essential for understanding viral evolution, disease epidemiology, diagnosis, drug resistance, etc. However, challenges remain in capturing complex mutation patterns and supporting diverse…

Quantitative Methods · Quantitative Biology 2026-04-24 Rui Wang , Xuhang Dai , Xin Cao , Changchuan Yin , Tamar Schlick , Guo-Wei Wei

A ubiquitous task in processing electronic medical data is the assignment of standardized codes representing diagnoses and/or procedures to free-text documents such as medical reports. This is a difficult natural language processing task…

In this paper, we present a customizable datacentric system that automatically generates common misspellings for complex health-related terms. The spelling variant generator relies on a dense vector model learned from large unlabeled text,…

Computation and Language · Computer Science 2023-06-21 Abeed Sarker , Graciela Gonzalez-Hernandez

Functional evidence is essential for clinical interpretation of genomic variants, but identifying relevant studies and translating experimental results into structured evidence remains labor intensive. We developed a benchmark based on…

Genomics · Quantitative Biology 2026-04-02 Ali Saadat , Jacques Fellay

Machine learning (ML) interpretability techniques can reveal undesirable patterns in data that models exploit to make predictions--potentially causing harms once deployed. However, how to take action to address these patterns is not always…

Novel neural architectures, training strategies, and the availability of large-scale corpora haven been the driving force behind recent progress in abstractive text summarization. However, due to the black-box nature of neural models,…

Computation and Language · Computer Science 2021-07-27 Jesse Vig , Wojciech Kryściński , Karan Goel , Nazneen Fatema Rajani

Variant calling is a fundamental task in genomic research, essential for detecting genetic variations such as single nucleotide polymorphisms (SNPs) and insertions or deletions (indels). This paper presents an enhancement to DeepChem, a…

Quantitative Methods · Quantitative Biology 2025-07-29 Ankita Vaishnobi Bisoi , Shreyas V , Jose Siguenza , Bharath Ramsundar

Recent strides in interpretable machine learning (ML) research reveal that models exploit undesirable patterns in the data to make predictions, which potentially causes harms in deployment. However, it is unclear how we can fix these…

This technical report introduces PaddleOCR 3.0, an Apache-licensed open-source toolkit for OCR and document parsing. To address the growing demand for document understanding in the era of large language models, PaddleOCR 3.0 presents three…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Cheng Cui , Ting Sun , Manhui Lin , Tingquan Gao , Yubo Zhang , Jiaxuan Liu , Xueqing Wang , Zelun Zhang , Changda Zhou , Hongen Liu , Yue Zhang , Wenyu Lv , Kui Huang , Yichao Zhang , Jing Zhang , Jun Zhang , Yi Liu , Dianhai Yu , Yanjun Ma

The classification of genetic variants, particularly Variants of Uncertain Significance (VUS), poses a significant challenge in clinical genetics and precision medicine. Large Language Models (LLMs) have emerged as transformative tools in…

Test-time reinforcement learning (TTRL) has emerged as a promising paradigm for self-evolving large reasoning models (LRMs), enabling online adaptation on unlabeled test inputs via self-induced rewards through majority voting. However, a…

Artificial Intelligence · Computer Science 2026-03-03 Ruotong Liao , Nikolai Röhrich , Xiaohan Wang , Yuhui Zhang , Yasaman Samadzadeh , Volker Tresp , Serena Yeung-Levy

TauREx 3 is the next generation of the TauREx exoplanet atmospheric retrieval framework for Windows, Mac, and Linux. It is a complete rewrite with a full Python stack that makes it easy-to-use, high-performance, dynamic, and flexible. The…

Instrumentation and Methods for Astrophysics · Physics 2021-08-19 Ahmed F. Al-Refaie , Quentin Changeat , Ingo P. Waldmann , Giovanna Tinetti

Medical applications challenge today's text categorization techniques by demanding both high accuracy and ease-of-interpretation. Although deep learning has provided a leap ahead in accuracy, this leap comes at the sacrifice of…

Generative models have achieved impressive fidelity in text-to-image synthesis, yet struggle with complex compositional prompts involving multiple constraints. We introduce \textbf{M3 (Multi-Modal, Multi-Agent, Multi-Round)}, a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-09 Bangji Yang , Ruihan Guo , Jiajun Fan , Chaoran Cheng , Ge Liu

Software undergoes constant changes to support new requirements, address bugs, enhance performance, and ensure maintainability. Thus, developers spend a great portion of their workday trying to understand and review the code changes of…

Software Engineering · Computer Science 2024-08-26 Pouria Alikhanifard , Nikolaos Tsantalis

Motivation: Computational methods are essential to extract actionable information from raw sequencing data, and to thus fulfill the promise of next-generation sequencing technology. Unfortunately, computational tools developed to call…

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