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Fragment-based shape signature techniques have proven to be powerful tools for computer-aided drug design. They allow scientists to search for target molecules with some similarity to a known active compound. They do not require reference…

Artificial Intelligence · Computer Science 2022-01-05 Thierry Petit , Randy J. Zauhar

A doubly type-II censored scheme is an important sampling scheme in the life testing experiment and reliability engineering. In the present commutation, we have considered estimating ordered scale parameters of two exponential distributions…

Statistics Theory · Mathematics 2024-12-09 Shrajal Bajpai , Lakshmi Kanta Patra

In the recent years, branch-and-cut algorithms have been the target of data-driven approaches designed to enhance the decision making in different phases of the algorithm such as branching, or the choice of cutting planes (cuts). In…

Optimization and Control · Mathematics 2025-06-03 Sammy Khalife , Andrea Lodi

We present the first linear lower bound for the number of bits required to be accessed in the worst case to increment an integer in an arbitrary space- optimal binary representation. The best previously known lower bound was logarithmic. It…

Computational Complexity · Computer Science 2017-02-16 M. Raskin

Estimating the second frequency moment $F_2$ of a data stream up to a $(1 \pm \varepsilon)$ factor is a central problem in the streaming literature. For errors $\varepsilon > \Omega(1/\sqrt{n})$, the tight bound…

Data Structures and Algorithms · Computer Science 2025-09-10 Naomi Green-Maimon , Or Zamir

The Adaptive Multilevel Splitting (AMS) algorithm is a powerful and versatile method for the simulation of rare events. It is based on an interacting (via a mutation-selection procedure) system of replicas, and depends on two integer…

Probability · Mathematics 2015-02-25 Charles-Edouard Bréhier

We consider the problem of distinguishing between two arbitrary black-box distributions defined over the domain [n], given access to $s$ samples from both. It is known that in the worst case O(n^{2/3}) samples is both necessary and…

Data Structures and Algorithms · Computer Science 2011-10-17 Eyal Even Dar , Mark Sandler

We introduce a suitable adapted ordering for the twisted N=2 superconformal algebra (i.e. with mixed boundary conditions for the fermionic fields). We show that the ordering kernels for complete Verma modules have two elements and the…

High Energy Physics - Theory · Physics 2009-10-31 Matthias Doerrzapf , Beatriz Gato-Rivera

In this paper, we consider lower bounds on the query complexity for testing CSPs in the bounded-degree model. First, for any ``symmetric'' predicate $P:{0,1}^{k} \to {0,1}$ except \equ where $k\geq 3$, we show that every (randomized)…

Data Structures and Algorithms · Computer Science 2010-07-21 Yuichi Yoshida

We prove that any semi-streaming algorithm for $(1-\epsilon)$-approximation of maximum bipartite matching requires \[ \Omega(\frac{\log{(1/\epsilon)}}{{\log{(1/\beta)}}}) \] passes, where $\beta \in (0,1)$ is the largest parameter so that…

Data Structures and Algorithms · Computer Science 2023-10-12 Sepehr Assadi , Janani Sundaresan

The unbounded knapsack problem with bounded weights is a variant of the well-studied variant of the traditional binary knapsack problem; key changes being the relaxation of the binary constraint and allowing the unit weights of each item to…

Data Structures and Algorithms · Computer Science 2021-09-29 Michael Beyer , Steven Mills

We show that for any odd $k$ and any instance of the Max-kXOR constraint satisfaction problem, there is an efficient algorithm that finds an assignment satisfying at least a $\frac{1}{2} + \Omega(1/\sqrt{D})$ fraction of constraints, where…

An additive 2-basis with range n is restricted if its largest element is n/2. Among the restricted 2-bases of given length k, the ones that have the greatest range are extremal restricted. We describe an algorithm that finds the extremal…

Number Theory · Mathematics 2018-10-04 Jukka Kohonen

We construct $n$-node graphs on which any $O(n)$-size spanner has additive error at least $+\Omega(n^{3/17})$, improving on the previous best lower bound of $\Omega(n^{1/7})$ [Bodwin-Hoppenworth FOCS '22]. Our construction completes the…

Data Structures and Algorithms · Computer Science 2024-04-30 Greg Bodwin , Gary Hoppenworth , Virginia Vassilevska Williams , Nicole Wein , Zixuan Xu

Given an array A containing arbitrary (positive and negative) numbers, we consider the problem of supporting range maximum-sum segment queries on A: i.e., given an arbitrary range [i,j], return the subrange [i' ,j' ] \subseteq [i,j] such…

Data Structures and Algorithms · Computer Science 2015-06-12 Pawel Gawrychowski , Patrick K. Nicholson

In this paper, we study the problem of mean estimation under 1-bit communication constraints. We propose a novel adaptive mean estimator based solely on randomized threshold queries, where each 1-bit outcome indicates whether a given sample…

Machine Learning · Statistics 2026-05-25 Ivan Lau , Jonathan Scarlett

We study the following problem, introduced by Chung et al. in 2006. We are given, online or offline, a set of coloured items of different sizes, and wish to pack them into bins of equal size so that we use few bins in total (at most…

Data Structures and Algorithms · Computer Science 2015-08-18 Andrew Twigg , Eduardo C. Xavier

Mixed-integer optimisation problems can be computationally challenging. Here, we introduce and analyse two efficient algorithms with a specific sequential design that are aimed at dealing with sampled problems within this class. At each…

Optimization and Control · Mathematics 2023-03-07 Mohammadreza Chamanbaz , Roland Bouffanais

In this paper we study the adaptive prefix coding problem in cases where the size of the input alphabet is large. We present an online prefix coding algorithm that uses $O(\sigma^{1 / \lambda + \epsilon}) $ bits of space for any constants…

Data Structures and Algorithms · Computer Science 2008-11-24 Travis Gagie , Marek Karpinski , Yakov Nekrich

In this paper we propose models of combinatorial algorithms for the Boolean Matrix Multiplication (BMM), and prove lower bounds on computing BMM in these models. First, we give a relatively relaxed combinatorial model which is an extension…

Computational Complexity · Computer Science 2018-01-17 Debarati Das , Michal Koucký , Michael Saks
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