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Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for…

Quantitative Methods · Quantitative Biology 2025-08-26 Surajit Das , Gourav Roy , Pavel Zun

Multi-organ segmentation is one of most successful applications of deep learning in medical image analysis. Deep convolutional neural nets (CNNs) have shown great promise in achieving clinically applicable image segmentation performance on…

Image and Video Processing · Electrical Eng. & Systems 2020-12-18 Hao Tang , Xingwei Liu , Kun Han , Shanlin Sun , Narisu Bai , Xuming Chen , Huang Qian , Yong Liu , Xiaohui Xie

The ability to automatically detect certain types of cells or cellular subunits in microscopy images is of significant interest to a wide range of biomedical research and clinical practices. Cell detection methods have evolved from…

Computer Vision and Pattern Recognition · Computer Science 2018-02-22 Yao Xue , Nilanjan Ray

Single cell segmentation is critical and challenging in live cell imaging data analysis. Traditional image processing methods and tools require time-consuming and labor-intensive efforts of manually fine-tuning parameters. Slight variations…

Quantitative Methods · Quantitative Biology 2019-04-24 Weikang Wang , David A. Taft , Yi-Jiun Chen , Jingyu Zhang , Callen T. Wallace , Min Xu , Simon C. Watkins , Jianhua Xing

The segmentation of organs in volumetric medical images plays an important role in computer-aided diagnosis and treatment/surgery planning. Conventional 2D convolutional neural networks (CNNs) can hardly exploit the spatial correlation of…

Image and Video Processing · Electrical Eng. & Systems 2024-05-21 Zhuoyuan Wang , Dong Sun , Xiangyun Zeng , Ruodai Wu , Yi Wang

Semantic segmentation of neuronal structures in 3D high-resolution fluorescence microscopy imaging of the human brain cortex can take advantage of bidimensional CNNs, which yield good results in neuron localization but lead to inaccurate…

Image and Video Processing · Electrical Eng. & Systems 2020-09-03 Filippo Maria Castelli , Matteo Roffilli , Giacomo Mazzamuto , Irene Costantini , Ludovico Silvestri , Francesco Saverio Pavone

Convolutional Neural Networks (CNNs) have been recently employed to solve problems from both the computer vision and medical image analysis fields. Despite their popularity, most approaches are only able to process 2D images while most…

Computer Vision and Pattern Recognition · Computer Science 2016-06-16 Fausto Milletari , Nassir Navab , Seyed-Ahmad Ahmadi

In this paper we introduce a novel method for segmentation that can benefit from general semantics of Convolutional Neural Network (CNN). Our segmentation proposes visually and semantically coherent image segments. We use binary encoding of…

Computer Vision and Pattern Recognition · Computer Science 2016-11-22 Mahdyar Ravanbakhsh , Hossein Mousavi , Moin Nabi , Lucio Marcenaro , Carlo Regazzoni

We present an efficient deep learning approach for the challenging task of tumor segmentation in multisequence MR images. In recent years, Convolutional Neural Networks (CNN) have achieved state-of-the-art performances in a large variety of…

Computer Vision and Pattern Recognition · Computer Science 2018-07-24 Pawel Mlynarski , Hervé Delingette , Antonio Criminisi , Nicholas Ayache

The segmentation of cell nuclei in tissue images stained with the blood dye hematoxylin and eosin (H$\&$E) is essential for various clinical applications and analyses. Due to the complex characteristics of cellular morphology, a large…

Image and Video Processing · Electrical Eng. & Systems 2024-07-26 Ziwei Cui , Jingfeng Yao , Lunbin Zeng , Juan Yang , Wenyu Liu , Xinggang Wang

Convolutional neural networks (CNNs) achieved the state-of-the-art performance in medical image segmentation due to their ability to extract highly complex feature representations. However, it is argued in recent studies that traditional…

Computer Vision and Pattern Recognition · Computer Science 2025-03-31 Zhendi Gong , Andrew P. French , Guoping Qiu , Xin Chen

Deep convolutional neural networks (CNNs) have shown excellent performance in object recognition tasks and dense classification problems such as semantic segmentation. However, training deep neural networks on large and sparse datasets is…

Computer Vision and Pattern Recognition · Computer Science 2017-12-25 Lorenz Berger , Eoin Hyde , M. Jorge Cardoso , Sebastien Ourselin

The quantitative analysis of cellular membranes helps understanding developmental processes at the cellular level. Particularly 3D microscopic image data offers valuable insights into cell dynamics, but error-free automatic segmentation…

Computer Vision and Pattern Recognition · Computer Science 2018-10-17 Dennis Eschweiler , Thiago V. Spina , Rohan C. Choudhury , Elliot Meyerowitz , Alexandre Cunha , Johannes Stegmaier

Fluorescence microscopy is an essential tool for the analysis of 3D subcellular structures in tissue. An important step in the characterization of tissue involves nuclei segmentation. In this paper, a two-stage method for segmentation of…

Image and Video Processing · Electrical Eng. & Systems 2020-01-10 David Joon Ho , Shuo Han , Chichen Fu , Paul Salama , Kenneth W. Dunn , Edward J. Delp

Volumetric medical segmentation is a critical component of 3D medical image analysis that delineates different semantic regions. Deep neural networks have significantly improved volumetric medical segmentation, but they generally require…

Image and Video Processing · Electrical Eng. & Systems 2024-07-18 Hanan Gani , Muzammal Naseer , Fahad Khan , Salman Khan

In this work, we present a memory-efficient fully convolutional network (FCN) incorporated with several memory-optimized techniques to reduce the run-time GPU memory demand during training phase. In medical image segmentation tasks,…

Image and Video Processing · Electrical Eng. & Systems 2020-03-25 Chenglong Wang , Masahiro Oda , Kensaku Mori

Semantic segmentation is the task to cluster pixels on an image belonging to the same class. It is widely used in the real-world applications including autonomous driving, medical imaging analysis, industrial inspection, smartphone camera…

Computer Vision and Pattern Recognition · Computer Science 2021-01-27 Baohua Sun , Weixiong Lin , Hao Sha , Jiapeng Su

Recently, deep convolutional neural networks have achieved great success for medical image segmentation. However, unlike segmentation of natural images, most medical images such as MRI and CT are volumetric data. In order to make full use…

Image and Video Processing · Electrical Eng. & Systems 2022-02-08 Yichi Zhang , Qingcheng Liao , Le Ding , Jicong Zhang

Models based on deep convolutional neural networks (CNN) have significantly improved the performance of semantic segmentation. However, learning these models requires a large amount of training images with pixel-level labels, which are very…

Computer Vision and Pattern Recognition · Computer Science 2018-02-05 Linwei Ye , Zhi Liu , Yang Wang

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha
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